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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Propene, 2-methyl-

RTECS #

UD0890000

CAS #

115-11-7

Updated

September 201

Molecular Weight

56.12

Molecular Formula

C4H8

Synonyms

1,1-Dimethylethene
1,1-Dimethylethylene
2-Methylpropene
2-Methylpropylene
gamma-Butylene
Isobutene
Isopropylidenemethylene

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 252000 mg/kg/105W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB99-147670

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 314000 mg/m3/2HVCVGH* -,54,1990
inhalation/mouse lethal concentration (16 percent kill): 250000 mg/m3/2HVCVGH* -,54,1990
inhalation/mouse lethal concentration (84 percent kill): 680000 mg/m3/2HVCVGH* -,54,1990
inhalation/mouse lowest published toxic concentration: 19.8 pph/10MBehavioral: General anestheticHPV280 -,-,2001
inhalation/mouse Lowest published lethal concentration: 32 pph/10MBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
HPV280 -,-,2001
inhalation/rat lethal concentration (50 percent kill): 550000 mg/m3/4HVCVGH* -,54,1990
inhalation/rat lethal concentration (16 percent kill): 514000 mg/m3/4HVCVGH* -,54,1990
inhalation/rat lethal concentration (84 percent kill): 720000 mg/m3/4HVCVGH* -,54,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 8000 ppm/13W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionHPV280 -,-,2001
oral/rat lowest published toxic dose: 4159.4 mg/kg/4W- intermittentBlood: LuekopeniaHPV280 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 250 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWTOPADD 33,517,2005
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUTAEX 22,161,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81854; Number of Industries 17; Total Number of Facilities 942; Number of Occupations 16; Total Number of Employees Exposed 7002; Total Number of Female Employees Exposed 982
National Occupational Hazard Survey 1974Hazard Code 81854; Number of Industries 13; Total Number of Facilities 432; Number of Occupations 22; Total Number of Employees Exposed 5502

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse
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