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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Propene, 1,1,3,3,3-pentafluoro-2-trifluoromethyl-

RTECS #

UD1800000

CAS #

382-21-8

Updated

September 201

Molecular Weight

200.04

Molecular Formula

C4F8

Synonyms

Isobutene, octafluoro-
Octafluoroisobutylene
Octafluoro-sec-butene
Perfluoroisobutylene
Perfluoroisobutylene (ACGIH)
PFIB

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 25 mg/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
TLSMA6 75,221,1963
inhalation/cat lethal concentration (50 percent kill): 25 mg/m3/2HVCVGH* -,296,1990
inhalation/guinea pig lethal concentration (50 percent kill): 1050 ppb/2HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
BIMEA5 57,247,1968
inhalation/mouse lethal concentration (50 percent kill): 15 mg/m3/2HVCVGH* -,296,1990
inhalation/mouse Lowest published lethal concentration: 10 mg/m3/2HLung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
GTPZAB 5(3),3,1961
inhalation/rabbit lethal concentration (50 percent kill): 25 mg/m3/2HVCVGH* -,296,1990
inhalation/rabbit lethal concentration (50 percent kill): 1200 ppb/2HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
BIMEA5 57,247,1968
inhalation/rat lethal concentration (50 percent kill): 7.5 mg/m3/2HVCVGH* -,296,1990
inhalation/rat lowest published lethal dose: 23000 mg/m3/20MLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Changes in lung weight
INHTE5 16,549,2004
inhalation/rat lethal concentration (50 percent kill): 500 ppb/6HENTOX* -,353,2005
inhalation/rat Lowest published lethal concentration: 23000 mg/m3/20MLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Changes in lung weight
INHTE5 16,549,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1500 µg/m3/6H/19W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Alteration of classical conditioning
TLSMA6 75,221,1963

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.01 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,353,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.01 ppm (0.082 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.01 ppm (0.08 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.01 ppm (0.082 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDshort term exposure limit 0.01 ppm (0.082 mg/m3), NOV2011
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.01 ppm (0.082 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,01 ppm (0,082 mg/m3); short term exposure limit 0,01 ppm (0,08 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.082 mg/m3, 2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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