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1 - Propene, 1,1,3,3,3 - pentafluoro - 2 - trifluoromethyl -

RTECS #: UD1800000

CAS #: 382-21-8


UPDATE: May 2009 MW: 200.04 MF: C4F8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Isobutene, octafluoro -
  2. Octafluoro - sec - butene
  3. Octafluoroisobutylene
  1. PFIB
  2. Perfluoroisobutylene
  3. Perfluoroisobutylene (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 25 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
TLSMA6 75,221,1963
inhalation
cat
lethal concentration (50 percent kill): 25 mg/m3/2 hour N/R VCVGH* -,296,1990
inhalation
guinea pig
lethal concentration (50 percent kill): 1,050 ppb/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
BIMEA5 57,247,1968
inhalation
mouse
lowest published lethal concentration: 10 mg/m3/2 hour Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
GTPZAB 5(3),3,1961
inhalation
mouse
lethal concentration (50 percent kill): 15 mg/m3/2 hour N/R VCVGH* -,296,1990
inhalation
rat
lethal concentration (50 percent kill): 7.5 mg/m3/2 hour N/R VCVGH* -,296,1990
inhalation
rat
lowest published lethal dose: 23,000 mg/m3/20 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Changes in lung weight
INHTE5 16,549,2004
inhalation
rat
lethal concentration (50 percent kill): 500 ppb/6 hour N/R ENTOX* -,353,2005
inhalation
rat
lowest published lethal concentration: 23,000 mg/m3/20 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Changes in lung weight
INHTE5 16,549,2004
inhalation
rabbit
lethal concentration (50 percent kill): 1,200 ppb/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
BIMEA5 57,247,1968
inhalation
rabbit
lethal concentration (50 percent kill): 25 mg/m3/2 hour N/R VCVGH* -,296,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,500 g/m3/6 hour/19 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Alteration of classical conditioning
TLSMA6 75,221,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.01 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,353,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.01 ppm (0.082 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 0.01 ppm (0.08 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.01 ppm (0.082 mg/m3), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.082 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.01 ppm (0.082 mg/m3), JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BIMEA5 Biologie Medicale (Paris). (Paris, France) 1903-75. Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

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