Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanone, 1-chloro-

RTECS #

UC0700000

CAS #

78-95-5

Updated

September 201

Molecular Weight

92.53

Molecular Formula

C3H5ClO

Synonyms

1-Chloro-2-ketopropane
1-Chloro-2-oxopropane
1-Chloro-2-propanone
Acetone, chloro-
Acetonyl chloride
A-Stoff
Chloracetone (French)
Chloroacetone
Chloroacetone (ACGIH)
Chloropropanone
Monochloracetone
Monochloroacetone
Tonite

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium6 mg/L (+enzymatic activation step)MUREAV 341,1,1994
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster100 pph/6MPREBA3 62,284,1946/1947

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human Lowest published lethal concentration: 605 ppm/10MNTIS** PB214-270
inhalation/human lowest published toxic concentration: 18 mg/m3Eye: LacrimationVCVGK* -,439,1994
inhalation/rat lethal concentration (50 percent kill): 262 ppm/1HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair
AIHAAP 47,375,1986
intraperitoneal/mouse lethal dose (50 percent kill): 92 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
OYYAA2 33,695,1987
intraperitoneal/rat lethal dose (50 percent kill): 80 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
OYYAA2 33,695,1987
oral/mouse lethal dose (50 percent kill): 127 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair
AIHAAP 47,375,1986
oral/rat lethal dose (50 percent kill): 100 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair
AIHAAP 47,375,1986
skin/guinea pig lethal dose (50 percent kill): 100 µL/kgKODAK* 21MAY1971
skin/rabbit lethal dose (50 percent kill): 141 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin and Appendages: Other: Hair
AIHAAP 47,375,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 650 mg/kg/17D- intermittentGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Gastritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570898

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 1 ppm (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAceiling concentration 1 ppm (3.8 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (3.8 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (3.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 1 ppm (3.8 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDceiling concentration 1 ppm (3.8 mg/m3), skin, NOV2011
Occupational Exposure Limit-ICELANDshort term exposure limit 1 ppm (3.8 mg/m3), skin, NOV2011
Occupational Exposure Limit-NEW ZEALANDceiling concentration 1 ppm (3.8 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUshort term exposure limit 1 ppm (3.8 mg/m3), JUL2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3.8 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5194; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 5; Total Number of Employees Exposed 4354; Total Number of Female Employees Exposed 729

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP