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Registry of Toxic Effects of Chemical Substances (RTECS)

Propene, 3-chloro-2-methyl-

RTECS #

UC8050000

CAS #

563-47-3

Updated

December 2012

Molecular Weight

90.56

Molecular Formula

C4H7Cl

Synonyms

1-Chloro-2-methyl-2-propene
2-Methallyl chloride
2-Methyl-2-propenyl chloride
2-Methylallyl chloride
2-Methyl-allylchlorid (German)
3-Chlor-2-methyl-prop-1-en (German)
3-Chloro-2-methyl-1-propene
3-Chloro-2-methylpropene
3-Chloro-2-methylpropene (IUPAC)
3-Chloroisobutylene
3-Cloro-2-metil-prop-1-ene (Italian)
beta-Methallyl chloride
beta-Methylallyl chloride
Chlorure de methallyle (French)
Cloruro di metallile (Italian)
gamma-Chloroisobutylene
Isobutenyl chloride
Methallyl chloride
Methyl allyl chloride
NCI-C54820

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster200 mg/LNTPTR* NTP-TR-300,1986
mutation in mammalian somatic cellslymphocyte/mouse23200 µg/LSCIEAS 236,933,1987
mutation in microorganisms/Salmonella typhimurium6 µmol/plate (+/-enzymatic activation step)BCPCA6 29,2611,1980
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster4500 ppmEMMUEG 23,208,1994
sister chromatid exchangeovary/hamster16 mg/LEMMUEG 13,133,1989
sister chromatid exchangeovary/hamster50000 µg/L (+/-enzymatic activation step)HPV022 -,-,2000
Unscheduled DNA SynthesisHeLa cell/human1 mmol/LCALEDQ 20,263,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 100 ppm/6H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Eye: Tumors
INHEAO 38,309,2000
oral/mouse lowest published toxic dose: 51500 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB86-247293/AS
oral/mouse lowest published toxic dose: 51500 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-300,1986
oral/mouse lowest published toxic dose: 51500 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
PAACA3 26,95,1985
oral/rat lowest published toxic dose: 77250 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Adrenal cortex tumors
NTPTR* NTP-TR-300,1986
oral/rat lowest published toxic dose: 38625 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
PAACA3 26,95,1985
oral/rat toxic dose: 77250 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
NTPTR* NTP-TR-300,1986
oral/rat lowest published toxic dose: 38625 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB86-247293/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human Lowest published lethal concentration: 22000 ppm/10M34ZIAG -,377,1969
inhalation/mouse Lowest published lethal concentration: 9.2 gm/m3/2HTPKVAL 3,103,1961
inhalation/mouse lethal concentration (50 percent kill): 7 gm/m3/2HTPKVAL 3,103,1961
inhalation/mouse lowest published toxic concentration: 4.6 gm/m3/2HBehavioral: SleepTPKVAL 3,103,1961
inhalation/rat lethal concentration (50 percent kill): 34 gm/m3/30MFAVUAI 7,35,1975
inhalation/rat lethal concentration (50 percent kill): >5000 mg/m3/4HHPV022 -,-,2000
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 3,103,1961
oral/cat lethal dose (50 percent kill): 750 mg/kgVCVGH* -,497,1990
oral/mouse lowest published lethal dose: 3160 mg/kgGastrointestinal: Other changes

Liver: Other changes

Blood: Changes in spleen
NTPTR* NTP-TR-300,1986
oral/mouse lethal dose (50 percent kill): 1370 mg/kgVCVGH* -,497,1990
oral/rat lethal dose (50 percent kill): 580 mg/kgVCVGH* -,497,1990
oral/rat lethal dose (50 percent kill): 848 mg/kgBehavioral: Tremor

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Hypermotility, diarrhea
HPV022 -,-,2000
oral/rat lethal dose (50 percent kill): 848 mg/kgBehavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage
NTIS** OTS0539687
skin/rabbit lowest published lethal dose: 2000 mg/kgBehavioral: Ataxia

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV022 -,-,2000

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 16 gm/m3/1H/5W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJOHYAY 46,217,1948
oral/mouse lowest published toxic dose: 10500 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-300,1986
oral/mouse lowest published toxic dose: 81250 mg/kg/13W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-300,1986
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV022 -,-,2000
oral/rat lowest published toxic dose: 7 gm/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-300,1986
oral/rat lowest published toxic dose: 19500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-300,1986
oral/rat lowest published toxic dose: 750 mg/kg/2W- intermittentGastrointestinal: GastritisHPV022 -,-,2000
oral/rat lowest published toxic dose: 19500 mg/kg/13W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV022 -,-,2000

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 63,325,1995
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,325,1995
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 63,325,1995
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 83971; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 2; Total Number of Employees Exposed 1683

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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