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Registry of Toxic Effects of Chemical Substances (RTECS)

Propene

RTECS #

UC6740000

CAS #

115-07-1; 676-63-1; 33004-01-2

Updated

September 201

Molecular Weight

42.09

Molecular Formula

C3H6

Synonyms

1-Propene (9CI)
1-Propylene
Methylethene
Methylethylene
NCI-C50077
Propylene
Propylene (ACGIH)
R 1270

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
specific locus testinhalation/rat200 ppm/6H/4WEMMUEG 43,265,2004

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 865200 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors
NTIS** PB86-145521/AS
inhalation/rat lowest published toxic concentration: 154500 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB86-145521/AS
inhalation/rat lowest published toxic concentration: 128750 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB86-145521/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >86 gm/m3/4HIMEMDT 60,161,1994

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1250 ppm/6H/14W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-272,1985
inhalation/mouse lowest published toxic concentration: 309000 mg/kg/103W- intermittentLung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Active as anti-cancer agent
NTIS** PB86-145521/AS
inhalation/rat lowest published toxic concentration: 5000 ppm/6H/2Y- intermittentOlfaction: Other olfaction effectsTXAPA9 76,288,1984

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 500 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 19,213,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal No Adequate DataIMEMDT 19,213,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 60,161,1994
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 60,161,1994
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 60,161,1994
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 678,76,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAAsphyxiant, JUL2008
Occupational Exposure Limit-BELGIUMAsphyxiant, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (172 mg/m3), MAY2011
Occupational Exposure Limit-MEXICOSimple asphyxiant, 2004
Occupational Exposure Limit-NEW ZEALANDSimple asphyxiant, JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (900 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10000 ppm (17500 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 900 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 63495; Number of Industries 7; Total Number of Facilities 162; Number of Occupations 25; Total Number of Employees Exposed 7305; Total Number of Female Employees Exposed 975
National Occupational Hazard Survey 1974Hazard Code 63495; Number of Industries 16; Total Number of Facilities 493; Number of Occupations 32; Total Number of Employees Exposed 7150

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
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