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Propene

RTECS #: UC6740000

CAS #: 115-07-1


UPDATE: May 2009 MW: 42.09 MF: C3H6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Propene (9CI)
  2. 1 - Propylene
  3. Methylethene
  4. Methylethylene
  1. NCI - C50077
  2. Propylene
  3. Propylene (ACGIH)
  4. R 1270


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
specific locus test inhalation
rat
200 ppm/4 week/6 hour EMMUEG 43,265,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 865,200 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors
NTIS** PB86-145521/AS
inhalation
rat
lowest published toxic concentration: 154,500 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB86-145521/AS
inhalation
rat
lowest published toxic concentration: 128,750 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors
NTIS** PB86-145521/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration : >86 gm/m3/4 hour N/R IMEMDT 60,161,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,250 ppm/6 hour/14 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-272,1985
inhalation
mouse
lowest published toxic concentration: 309,000 mg/kg/103 week- intermittent Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Active as anti-cancer agent
NTIS** PB86-145521/AS
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects TXAPA9 76,288,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,213,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,213,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 60,161,1994
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,161,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,161,1994
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA Asphyxiant, JUL2008
Occupational Exposure Limit - BELGIUM Asphyxiant, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (172 mg/m3), OCT 2002
Occupational Exposure Limit - MEXICO Simple asphyxiant, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 900 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND Simple asphyxiant, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 500 ppm (900 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10000 ppm (17500 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 63495;
Number of Industries 16;
Total Number of Facilities 493;
Number of Occupations 32;
Total Number of Employees Exposed 7,150
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 63495;
Number of Industries 7;
Total Number of Facilities 162;
Number of Occupations 25;
Total Number of Employees Exposed 7,305;
Total Number of Female Employees Exposed 975


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of fabricated polymers, fibers and solvents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in production of fabricated polymers, fibers and solvents

Top 50 chemical production: 22.60 billions lbs in 1992, 21.55 billions in 1991

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (ALKENES), SRC, 4/78

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 676-63-1
ALT CAS #: 33004-01-2
Click Here for Additional Information about RTECS

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