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2 - Propanol, 1,1' - oxydi -

RTECS #: UB8785000

CAS #: 110-98-5


UPDATE: February 2003 MW: 134.20 MF: C6H14O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,1' - Dimethyldiethylene glycol
  2. 1,1' - Oxydi - 2 - propanol
  3. 2,2' - Dihydroxydipropyl ether
  4. 2,2' - Dihydroxyisopropyl ether
  5. 2 - Propanol, 1,1' - oxybis - (9CI)
  1. Bis (2 - hydroxypropyl) ether
  2. Dipropylene glycol
  3. Dipropylenglykol (Czech)
  4. NIAX catalyst D - 19


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg mild AJOPAA 29,1363,1946
skin
rabbit
500 ÁL/24 hour moderate NTIS** OTS0535986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 4,494 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FEPRA7 6,342,1947
intraperitoneal
rat
lethal dose (50 percent kill): 10 gm/kg N/R FCTXAV 16,729,1978
intravenous
dog
lethal dose (50 percent kill): 11,500 mg/kg Behavioral: Antipsychotic FCTXAV 16,729,1978
intravenous
rat
lethal dose (50 percent kill): 5,800 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
AMIHBC 3,448,1951
oral
guinea pig
lethal dose (50 percent kill): 17,600 ÁL/kg N/R GWXXBX #2703360
oral
rat
lethal dose (50 percent kill): 14,800 mg/kg N/R VCVGK* -,157,1984
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 12/17/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JACTDZ 4(5),223,1985


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9011;
Number of Industries 12;
Total Number of Facilities 184;
Number of Occupations 13;
Total Number of Employees Exposed 3,536;
Total Number of Female Employees Exposed 1,385


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent in inks, extraction of aromatics, and preparation of plasticizers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent in inks, extraction of aromatics, and preparation of plasticizers and resins

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

Click Here for Additional Information about RTECS

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