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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanol, 1,1'-oxydi-

RTECS #

UB8785000

CAS #

110-98-5

Updated

October 2010

Molecular Weight

134.20

Molecular Formula

C6H14O3

Synonyms

1,1'-Dimethyldiethylene glycol
1,1'-Oxydi-2-propanol
2,2'-Dihydroxydipropyl ether
2,2'-Dihydroxyisopropyl ether
2-Propanol, 1,1'-oxybis- (9CI)
Bis(2-hydroxypropyl) ether
Dipropylene glycol
Dipropylenglykol (Czech)
NIAX catalyst D-19

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
skin /rabbit 500 µL/24H moderateNTIS** OTS0535986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 4494 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)FEPRA7 6,342,1947
intraperitoneal/rat lethal dose (50 percent kill): 10 gm/kgFCTXAV 16,729,1978
intrauterine/man lowest published toxic dose: 7.14 mL/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed
AJEMEN 26,635e1,2008
intravenous/Dog lethal dose (50 percent kill): 11500 mg/kgBehavioral: AntipsychoticFCTXAV 16,729,1978
intravenous/rat lethal dose (50 percent kill): 5800 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
AMIHBC 3,448,1951
oral/guinea pig lethal dose (50 percent kill): 17600 µL/kgGWXXBX #2703360
oral/man lowest published toxic dose: 7.14 mL/kgPeripheral Nerve and Sensation: Structural change in nerve or sheath

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Musculoskeletal: Other changes
AJEMEN 26,635.e1,2008
oral/rat lethal dose (50 percent kill): 14800 mg/kgVCVGK* -,157,1984
skin/rabbit lethal dose (50 percent kill): >20 mL/kgUCDS** 12/17/1971

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 4(5),223,1985

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X9011; Number of Industries 12; Total Number of Facilities 184; Number of Occupations 13; Total Number of Employees Exposed 3536; Total Number of Female Employees Exposed 1385

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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