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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanol, 1,1',1''-nitrilotri-

RTECS #

UB8750000

CAS #

122-20-3

Updated

April 2010

Molecular Weight

191.31

Molecular Formula

C9H21NO3

Synonyms

1,1',1''-Nitrilotri-2-propanol
Triisopropanolamine
Tris(2-hydroxy-1-propyl)amine
Tris(2-hydroxypropyl)amine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mg severeAJOPAA 29,1363,1946

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lethal dose (50 percent kill): 1580 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 2520 mg/kgBehavioral: Muscle contraction or spasticityGISAAA 45(3),79,1980
oral/rabbit lethal dose (50 percent kill): 11 gm/kgBehavioral: Muscle contraction or spasticityGISAAA 45(3),79,1980
oral/rat lethal dose (50 percent kill): 4730 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 30(7),46,1986
oral/rat lethal dose (50 percent kill): 6500 mg/kgHPV363 -,-,2003
skin/mammal (species unspecified) lethal dose (50 percent kill): >1 gm/kgGTPZAB 30(7),46,1986
skin/rabbit lowest published lethal dose: 10 mL/kgUCDS** 4/21/1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 28 gm/kg/2W- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight
JACTDZ 6(1),53,1987
oral/rat lowest published toxic dose: 7800 mg/kg/30D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
HPV363 -,,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0259; Number of Industries 51; Total Number of Facilities 2702; Number of Occupations 58; Total Number of Employees Exposed 64304; Total Number of Female Employees Exposed 8631
National Occupational Hazard Survey 1974Hazard Code M0259; Number of Industries 27; Total Number of Facilities 1842; Number of Occupations 44; Total Number of Employees Exposed 23845

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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