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2 - Propanol, 1 - methoxy -

RTECS #: UB7700000

CAS #: 107-98-2


UPDATE: May 2009 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Methoxy - 2 - propanol
  2. Dowanol 33B
  3. Dowanol PM
  4. Dowanol PM glycol ether
  5. Dowtherm 209
  6. Glycol ether PM
  7. Methoxy ether of propylene glycol
  8. Methyl proxitol
  9. PGME
  1. Poly - Solve MPM
  2. Propasol solvent M
  3. Propylene glycol methyl ether
  4. Propylene glycol monomethyl ether
  5. Propylene glycol monomethyl ether (ACGIH)
  6. Propylenglykol - monomethylaether (German)
  7. Ucar Solvent LM (Obs.)
  8. alpha - Propylene glycol monomethyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,625,1986
skin
rabbit
500 mg open irritation test mild UCDS** 11/15/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 3,000 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 4,784,1984
inhalation
rat
lowest published toxic concentration: 3,000 ppm/6 hour (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Physical
TOSCF2 50,249,1999
oral
mouse
lowest published toxic dose: 3.3 gm/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB86170578
oral
mouse
lowest published toxic dose: 3.3 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB86170578
oral
mouse
lowest published toxic dose: 3.3 gm/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86170578
oral
mouse
lowest published toxic dose: 115.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB86170578
oral
rat
lowest published toxic dose: 50,501.25 mg/kg (15 day prior to copulation) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TIHEEC 21,33,2005
oral
rat
lowest published toxic dose: 59,395.5 mg/kg (15 day prior to copulation) Reproductive: Other effects on female

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TIHEEC 21,33,2005
oral
rabbit
lowest published toxic dose: 936 mg/kg (7-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOSCF2 71,217,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 15,000 ppm/7 hour Behavioral: Sleep AMIHBC 9,509,1954
inhalation
human
lowest published toxic concentration: 3,000 ppm Olfaction: Tumors

Behavioral: General anesthetic

Gastrointestinal: Nausea or vomiting
NPIRI* 1,105,1974
inhalation
human
lowest published toxic concentration: 2,580 mg/m3 Eye: Lacrimation VCVGK* -,169,1984
inhalation
human
lowest published toxic concentration: 7,540 mg/m3 Eye: Conjunctiva irritation VCVGK* -,169,1984
inhalation
human
lowest published toxic concentration: 830 mg/m3/1 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,170,1984
inhalation
mouse
lowest published toxic concentration: 1,000 ppm Liver: Other changes TOXID9 72,178,2003
inhalation
mouse
lowest published toxic concentration: 3,000 ppm Behavioral: Antianxiety TOXID9 72,178,2003
inhalation
rat
lethal concentration (50 percent kill): 10,000 ppm/5 hour N/R NPIRI* 1,105,1974
inhalation
rat
lowest published toxic concentration: 18,400 mg/m3 Behavioral: Alteration of classical conditioning VCVGK* -,169,1984
inhalation
rat
lowest published toxic concentration: 1,000 ppm Liver: Other changes TOXID9 72,178,2003
inhalation
rat
lowest published toxic concentration: 1,000 ppm Kidney, Ureter, and Bladder: Other changes TOXID9 72,178,2003
inhalation
rat
lowest published toxic concentration: 3,000 ppm Behavioral: Antianxiety TOXID9 72,178,2003
inhalation
rabbit
lowest published lethal concentration: 15,000 ppm/7 hour N/R AMIHBC 9,509,1954
intraperitoneal
mouse
lethal dose : >500 mg/kg N/R CBCCT* 4,110,1952
intraperitoneal
rat
lethal dose (50 percent kill): 3,720 mg/kg N/R 38MKAJ 2C,3977,1982
intravenous
dog
lethal dose (50 percent kill): 2 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
intravenous
mouse
lethal dose (50 percent kill): 5,300 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
intravenous
rat
lethal dose (50 percent kill): 4,200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
intravenous
rabbit
lethal dose (50 percent kill): 1,200 mg/kg N/R ARZNAD 22,569,1972
oral
dog
lethal dose (50 percent kill): 5 gm/kg N/R ARZNAD 22,569,1972
oral
mouse
lethal dose (50 percent kill): 11,700 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
oral
rat
lowest published lethal dose: 3,739 mg/kg Eye: Chromodacryorrhea

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** OTS0520402
oral
rat
lethal dose (50 percent kill): 6,600 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,169,1984
oral
rabbit
lethal dose (50 percent kill): 5,700 mg/kg N/R ARZNAD 22,569,1972
subcutaneous
rat
lethal dose (50 percent kill): 7,800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 22,569,1972
subcutaneous
rabbit
lethal dose (50 percent kill): 5 gm/kg N/R ARZNAD 22,569,1972
skin
rabbit
lethal dose (50 percent kill): 13 gm/kg N/R NPIRI* 1,105,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 6,000 ppm/7 hour/16 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 9,509,1954
inhalation
monkey
lowest published toxic concentration: 10,000 ppm/4 hour/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 9,509,1954
inhalation
mouse
lowest published toxic concentration: 3,000 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight TXAPA9 61,368,1981
inhalation
rat
lowest published toxic concentration: 3,000 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
TXAPA9 61,368,1981
inhalation
rat
lowest published toxic concentration: 3,000 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight FAATDF 3,627,1983
inhalation
rat
lowest published toxic concentration: 11,000 mg/m3/6 hour/9 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
VCVGK* -,170,1994
inhalation
rat
lowest published toxic concentration: 2,200 mg/m3/12 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,170,1994
inhalation
rabbit
lowest published toxic concentration: 3,000 ppm/6 hour/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 3,627,1983
multiple
human
lowest published toxic dose: 100 ppm/3 hour/2 week- intermittent Olfaction: Other olfaction effects TOLED5 135,S30,2002
multiple
human
lowest published toxic dose: 150 ppm/3 hour/2 week- intermittent Olfaction: Other olfaction effects

Eye: Conjunctiva irritation
TOLED5 135,S30,2002
oral
mouse
lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral
mouse
lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral
rat
lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral
rat
lowest published toxic dose: 40 mL/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,170,1994
oral
rat
lowest published toxic dose: 280,435.2 mg/kg/64 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TIHEEC 21,33,2005
skin
rabbit
lowest published toxic dose: 455 mL/kg/13 week- intermittent Behavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 9,509,1954
skin
rabbit
lowest published toxic dose: 900 mL/kg/90 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,170,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 150 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
CRTXB2 30,307,2000
TOXICOLOGY REVIEW
TOLED5 140-141,249,2003
TOXICOLOGY REVIEW
ENTOX* -,451,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (360 mg/m3) DTLWS* 3,27,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (369 mg/m3), short term exposure limit 150 ppm (553 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (375 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 150 ppm (568 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (185 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 375 mg/m3 (100 ppm);
short term exposure limit 568 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (360 mg/m3), short term exposure limit 150 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (375 mg/m3), VLE 150 ppm (568 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 370 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 375 mg/m3, short term exposure limit 568 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (360 mg/m3), short term exposure limit 150 ppm (540 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 375 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (369 mg/m3), short term exposure limit 150 ppm (553 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (180 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (190 mg/m3);
short term exposure limit 75 ppm (300 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (360 mg/m3),KZG- week 200 ppm (720 mg/m3),DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (375 mg/m3);
short term exposure limit 150 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm;
short term exposure limit 150 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm;
short term exposure limit 150 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 100 ppm;
short term exposure limit 150 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81815;
Number of Industries 44;
Total Number of Facilities 5,953;
Number of Occupations 36;
Total Number of Employees Exposed 26,413
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81815;
Number of Industries 204;
Total Number of Facilities 25,947;
Number of Occupations 133;
Total Number of Employees Exposed 373,990;
Total Number of Female Employees Exposed 110,572


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for coatings, cellulose, acrylics dyes, inks, and stains
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #99


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent for coatings, cellulose, acrylics dyes, inks, and stains

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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