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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanol, 1,1'-iminodi-

RTECS #

UB6600000

CAS #

110-97-4

Updated

July 2013

Molecular Weight

133.22

Molecular Formula

C6H15NO2

Synonyms

1,1'-Iminobis-2-propanol
1,1'-Iminodi-2-propanol
2-Propanol, 1,1'-iminobis- (9CI)
Bis(2-hydroxypropyl)amine
Bis(2-propanol)amine
Di-2-propanolamine
Diisopropanolamine
DIPA (alcohol)
Dipropyl-2,2'-dihydroxy-amine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg severeUCDS** 5/21/1971
skin /rabbit 500 mg open irritation test mildUCDS** 5/21/1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 804.3 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intraperitoneal/mouse lethal dose (50 percent kill): 96 mg/kgAutonomic Nervous System: Beta adrenergic blockerAIMJA9 30,23,1979
oral/rat lethal dose (50 percent kill): 4765 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 30(7),46,1986
skin/mammal (species unspecified) lethal dose (50 percent kill): >1 gm/kgGTPZAB 30(7),46,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 42 gm/kg/2W- continuousMusculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 6(1),53,1987
oral/rat lowest published toxic dose: 9100 mg/kg/13W- continuousKidney, Ureter, and Bladder: Changes in kidney weightFCTOD7 45,1838,2007
oral/rat lowest published toxic dose: 91000 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCTOD7 45,1838,2007
skin/rat lowest published toxic dose: 14000 mg/kg/4W- intermittentSkin: After topical application: Primary irritationFCTOD7 45,1838,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1242; Number of Industries 26; Total Number of Facilities 1278; Number of Occupations 43; Total Number of Employees Exposed 35237; Total Number of Female Employees Exposed 3439
National Occupational Hazard Survey 1974Hazard Code A1242; Number of Industries 34; Total Number of Facilities 6081; Number of Occupations 44; Total Number of Employees Exposed 73790

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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