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2 - Propanol, 1,1' - iminodi -

RTECS #: UB6600000

CAS #: 110-97-4


UPDATE: May 2008 MW: 133.22 MF: C6H15NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1' - Iminobis - 2 - propanol
  2. 1,1' - Iminodi - 2 - propanol
  3. 2 - Propanol, 1,1' - iminobis - (9CI)
  4. Bis (2 - hydroxypropyl) amine
  5. Bis (2 - propanol) amine
  1. DIPA (alcohol)
  2. Di - 2 - propanolamine
  3. Diisopropanolamine
  4. Dipropyl - 2,2' - dihydroxy - amine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg severe UCDS** 5/21/1971
skin
rabbit
500 mg open irritation test mild UCDS** 5/21/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 96 mg/kg Autonomic Nervous System: Beta adrenergic blocker AIMJA9 30,23,1979
oral
rat
lethal dose (50 percent kill): 4,765 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 30(7),46,1986
skin
mammal (species unspecified)
lethal dose (50 percent kill): >1 gm/kg N/R GTPZAB 30(7),46,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 42 gm/kg/2 week- continuous Musculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 6(1),53,1987
oral
rat
lowest published toxic dose: 9,100 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight FCTOD7 45,1838,2007
oral
rat
lowest published toxic dose: 91,000 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCTOD7 45,1838,2007
skin
rat
lowest published toxic dose: 14,000 mg/kg/4 week- intermittent Skin: After topical application: Primary irritation FCTOD7 45,1838,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1242;
Number of Industries 34;
Total Number of Facilities 6,081;
Number of Occupations 44;
Total Number of Employees Exposed 73,790
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1242;
Number of Industries 26;
Total Number of Facilities 1,278;
Number of Occupations 43;
Total Number of Employees Exposed 35,237;
Total Number of Female Employees Exposed 3,439


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to treat sour natural gas, as raw material and emulsifying agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIMJA9 Ain Shams Medical Journal. (Ain Shams Clinical and Scientific Soc., c/o Ain Shams Univ. Hospital, Abbassia, Cairo, Egypt) V.1- 1950-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used to treat sour natural gas, as raw material and emulsifying agent

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Primary Irritant

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