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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Propanol, 2,3-dibromo-, phosphate (3:1)

RTECS #

UB0350000

CAS #

126-72-7

Updated

December 2012

Molecular Weight

697.67

Molecular Formula

C9H15Br6O4P

Synonyms

(2,3-Dibromopropyl) phosphate
2,3-Dibromo-1-propanol phosphate
Anfram 3PB
APEX 462-5
Bromkal P 67-6HP
ES685
Firemaster LV-T 23P
Firemaster T23P
Firemaster T23P-LV
Flacavon R
Flamex T 23P
Flammex AP
Flammex LV-T 23P
Flammex T 23P
Fyrol HB32
NCI-C03270
Phosphoric acid, tris(2,3-dibromopropyl) ester
RCRA waste number U235
T 23P
TDBP
TDBP (Czech)
TDBPP
Tris (flame retardant)
Tris(2,3-dibromopropyl) phosphate
Tris(2,3-dibromopropyl) phosphoric acid ester
Tris(2,3-dibromopropyl)phosphate
Tris-(2,3-dibrompropyl)fosfat (Czech)
Tris(dibromopropyl)phosphate
Tris-2,3-dibrompropyl ester kyseliny fosforecne (Czech)
Tris-BP
USAF DO-41
Zetifex ZN

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,1137,1986
skin /rabbit 2 mg/24H severe85JCAE -,1137,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat500 mg/kgCTOXAO 17,101,1980
body fluid assaySalmonella typhimurium/mouse50 mg/kgJEPTDQ 3(1-2),207,1979
Cytogenetic Analysisintravenous/mouse1500 mg/kgMUREAV 60,329,1979
Cytogenetic Analysislymphocyte/mouse10 mg/LJEPTDQ 3(1-2),207,1979
Cytogenetic Analysislung/hamster100 mg/LAMONDS 3,253,1980
DNA Damageintraperitoneal/rat2500 nmol/LCBINA8 82,195,1992
DNA Damageliver/rat10 µmol/LCBINA8 82,195,1992
DNA Damageother cell types/human2 mg/LMUREAV 56,89,1977
DNA repair/Escherichia coli10 µg/plateMUREAV 74,107,1980
heritable translocation testoral/Drosophila melanogaster1000 ppm/2D-continuousMUREAV 57,385,1978
micronucleus testintraperitoneal/mouse1020 mg/kgJJIND8 66,691,1981
micronucleus testintraperitoneal/rat250 µmol/kgCRNGDP 15,1197,1994
micronucleus testintraperitoneal/hamster400 mg/kgEJCODS 18,1337,1982
morphological transformembryo/hamster25 mg/LEJCODS 18,1337,1982
morphological transformembryo/rat1270 ng/plateJJATDK 1,190,1981
morphological transformlymphocyte/mouse2500 µg/LJEPTDQ 3(1-2),207,1979
mutation in mammalian somatic cellslung/hamster20 µmol/LMUREAV 124,213,1983
mutation in mammalian somatic cellsoral/mouse1200 mg/kg/4D-continuousEMMUEG 28,342,1996
mutation in mammalian somatic cellslymphocyte/mouse5 ppmMUREAV 53,160,1978
mutation in microorganismslung/hamster20 µmol/L (+enzymatic activation step)APTOA6 56,20,1985
mutation in microorganismslymphocyte/mouse25 mg/L (+enzymatic activation step)JEPTDQ 3(1-2),207,1979
mutation in microorganisms/Salmonella typhimurium2270 µg/plate (+enzymatic activation step)MUREAV 57,381,1978
mutation in microorganisms/Salmonella typhimurium110 nmol/plate (-enzymatic activation step)MUTAEX 2,287,1987
mutation in microorganisms/Escherichia coli100 µg/plate (+enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
sex chromosome loss and nondisjunctionunreported route/Drosophila melanogaster1000 ppmJEPTDQ 3(1-2),207,1979
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster500 ppmENMUDM 1,144,1979
sister chromatid exchangeembryo/human69700 µg/LSNSHBT (20),574,1980
sister chromatid exchangeintravenous/mouse1500 mg/kgMUREAV 60,329,1979
sister chromatid exchangelymphocyte/mouse5 mg/LJEPTDQ 3(1-2),207,1979
sister chromatid exchangelung/mouse125 mg/kgJNCIAM 60,1179,1978
sister chromatid exchangeparenteral/chicken424 µg/kg47JMAE -,137,1982
sister chromatid exchangelung/hamster5 mg/LJNCIAM 60,1179,1978
specific locus testoral/rat12.5 gm/kg/45D-continuousEMMUEG 36,1,2000
specific locus testoral/Drosophila melanogaster250 µmol/LCRNGDP 15,1197,1994
sperm morphologyintraperitoneal/mouse4085 mg/kg/5D- intermittentJJIND8 66,691,1981
Unscheduled DNA Synthesisliver/rat50 µmol/LMUREAV 124,213,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 8510 mg/kg (72D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JACTDZ 5(2),153,1986
intraperitoneal/rat 4260 mg/kg (72D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsJACTDZ 5(2),153,1986
oral/rat 1800 mg/kg (7-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vaginaESKHA5 (98),50,1980
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFCTXAV 19,67,1981
oral/rat 450 mg/kg (7-15D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)JTSCDR 4,296,1979
oral/rat 1800 mg/kg (7-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJTSCDR 8,339,1983

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 39 gm/kg/92W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NCITR* NCI-TR-76,1978
oral/mouse toxic dose: 87 gm/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NCITR* NCI-TR-76,1978
oral/mouse toxic dose: 43 gm/kg/103W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NCITR* NCI-TR-76,1978
oral/rat toxic dose: 1820 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FCTXAV 18,743,1980
oral/rat toxic dose: 43680 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
FCTXAV 18,743,1980
oral/rat toxic dose: 26 gm/kg/52W- intermittentTumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Colon tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
LAINAW 44,74,1981
oral/rat toxic dose: 3600 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NCITR* NCI-TR-76,1978
oral/rat toxic dose: 1800 mg/kg/103W- continuousTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NCITR* NCI-TR-76,1978
oral/rat lowest published toxic dose: 1330 mg/kg/76W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NCITR* NCI-TR-76,1978
skin/mouse lowest published toxic dose: 85 gm/kg/71W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
CNREA8 38,3236,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 6800 mg/kgBehavioral: ExcitementGTPZAB 29(12),53,1985
oral/rat lethal dose (50 percent kill): 810 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Other changes
SRTCAC 36(1-4),10,1989
skin/rabbit lethal dose (50 percent kill): >8 gm/kgFRCHD6 1,205,1974
unreported route/mouse lethal dose (50 percent kill): 1149 mg/kgJJIND8 66,691,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1400 mg/kg/7D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition
JJATDK 7,23,1987
skin/rabbit lowest published toxic dose: 29510 mg/kg/13W- intermittentLiver: Changes in liver weight

Related to Chronic Data: Changes in testicular weight
JTEHD6 3,979,1977

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,575,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,905,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,369,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,905,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2AIMEMDT 71,905,1999
TOXICOLOGY REVIEWENVRAL 13,74,1977
TOXICOLOGY REVIEWCTOXAO 17,101,1980
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 658,124,2008
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWMUREAV 705,184,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code M1916; Number of Industries 2; Total Number of Facilities 18; Number of Occupations 7; Total Number of Employees Exposed 206

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-76,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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