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1 - Propanol, 2,3 - epoxy -

RTECS #: UB4375000

CAS #: 556-52-5


UPDATE: May 2009 MW: 74.09 MF: C3H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,3 - Epoxy - 1 - propanol (ACGIH:OSHA)
  2. 2,3 - Epoxypropanol
  3. 3 - Hydroxy - 1,2 - epoxypropane
  4. Epihydrin alcohol
  5. Glycide
  1. Glycidol
  2. Glycidol (ACGIH:OSHA)
  3. Glycidyl alcohol
  4. Methanol, oxiranyl -
  5. NCI - C55549


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
2 mg/24 hour severe 85JCAE -,769,1986
skin
rabbit
558 mg/3 day moderate AMIHAB 14,250,1956
skin
rabbit
100 mg/24 hour moderate 85JCAE -,769,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 12,500 µg/L NTPTR* NTP-TR-374,1990
cytogenetic analysis human lymphocyte 400 µmol/L MUREAV 91,243,1981
cytogenetic analysis intraperitoneal
rat
320 mg/kg FCTOD7 22,665,1984
cytogenetic analysis oral
rat
600 mg/kg FCTOD7 22,665,1984
DNA damage hamster ovary 20 mg/L/3 hour FCTOD7 45,41,2007
DNA repair Escherichia coli 10 gm/L MUREAV 130,141,1984
mutation in microorganisms Escherichia coli 500 µmol/L (-enzymatic activation step) TOLED5 4,103,1979
mutation in microorganisms Klebsiella pneumoniae 200 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Neurospora crassa 500 mmol/L (-enzymatic activation step) GENTAE 40,890,1955
mutation in microorganisms Salmonella typhimurium 3 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
gene conversion and mitotic recombination Saccharomyes cerevisiae 2,500 ppm JJIND8 62,901,1979
mutation in mammalian somatic cells hamster lung 1 µmol/L CRNGDP 11,497,1990
mutation in mammalian somatic cells mouse lymphocyte 1,250 µg/kg NTPTR* NTP-TR-374,1990
morphological transform hamster embryo 10 µg/L IJCNAW 19,642,1977
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems Escherichia coli 1 mmol/L MUREAV 231,205,1990
sister chromatid exchange hamster ovary 10,100 µg/L NTPTR* NTP-TR-374,1990
sister chromatid exchange hamster lung 1,250 µmol/L MUREAV 249,55,1991
sister chromatid exchange human lymphocyte 50 µmol/L MUREAV 91,243,1981
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
3,690 ppm NTPTR* NTP-TR-374,1990
specific locus test mouse other cell types 30 gm/L/24 hour EMMUEG 45,80,2005
heritable translocation test oral
Drosophila melanogaster
1,230 ppm NTPTR* NTP-TR-374,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) BCSTB5 1,523,1973
oral
mouse
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 9,87,1982
oral
mouse
lowest published toxic dose: 6,825 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NTP-TR-374,1990
oral
rat
lowest published toxic dose: 180 mg/kg (12 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NATUAS 226,87,1970
oral
rat
lowest published toxic dose: 18,200 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTPTR* NTP-TR-374,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 25,750 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-374,1990
oral
mouse
lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
NTIS** PB90-259094
oral
mouse
lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
NTIS** PB90-259094
oral
rat
lowest published toxic dose: 38,625 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-374,1990
oral
rat
lowest published toxic dose: 19,312.5 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
NTIS** PB90-259094
oral
rat
lowest published toxic dose: 19,312.5 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NTIS** PB90-259094


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 450 ppm/4 hour Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
AMIHAB 14,250,1956
inhalation
mouse
lethal concentration (50 percent kill): 1,069 mg/m3/4 hour Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 15,97,1979
inhalation
mouse
lowest published toxic concentration: 100 mg/m3/4 hour N/R TPKVAL 15,97,1979
inhalation
rat
lethal concentration (50 percent kill): 580 ppm/8 hour Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
AMIHAB 14,250,1956
inhalation
rat
lethal concentration (50 percent kill): 1,260 mg/m3/4 hour N/R TPKVAL 15,97,1979
inhalation
rat
lowest published toxic concentration: 100 mg/m3/4 hour N/R TPKVAL 15,97,1979
intraperitoneal
mouse
lethal dose (50 percent kill): 500 mg/kg N/R PSEBAA 35,98,1936
intraperitoneal
rat
lethal dose (50 percent kill): 200 mg/kg N/R FCTXAV 19,347,1981
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 15,97,1979
oral
mouse
lethal dose (50 percent kill): 431 mg/kg N/R GTPZAB 24(3),42,1980
oral
mouse
lethal dose (50 percent kill): 431 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 15,97,1979
oral
rat
lethal dose (50 percent kill): 420 mg/kg N/R FCTXAV 19,347,1981
skin
rabbit
lethal dose (50 percent kill): 1,980 mg/kg N/R AMIHAB 14,250,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 125 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS GTPZAB 24(3),42,1980
inhalation
rat
lowest published toxic concentration: 125 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Other changes
GTPZAB 24(3),42,1980
oral
mouse
lowest published toxic dose: 9,600 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-374,1990
oral
mouse
lowest published toxic dose: 27,300 mg/kg/13 week- intermittent Brain and Coverings: Demyelination

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-374,1990
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-91019
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Immunological Including Allergic: Decreased immune response

Immunological Including Allergic: Increased immune response
NTPTR* IMM-91019
oral
mouse
lowest published toxic dose: 350 mg/kg/14 day- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Increase in cellular immune response
NTPTR* IMM-91019
oral
rat
lowest published toxic dose: 9,600 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-374,1990
oral
rat
lowest published toxic dose: 36,400 mg/kg/13 week- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Other changes
NTPTR* NTP-TR-374,1990
skin
rabbit
lowest published toxic dose: 100 pph/5 day- intermittent Skin: After topical application: Primary irritation TPKVAL 15,97,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 77,564,2000
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (150 mg/m3) DTLVS* 3,121,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (150 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (76 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRIA TRK 150 mg/m3 (50 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (6.2 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.2 ppm (1 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (225 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (75 mg/m3), continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 25 ppm (75 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (75 mg/m3);
short term exposure limit 100 ppm (300 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (76 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (150 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (150 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLYCIDOL-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 35120;
Number of Industries 3;
Total Number of Facilities 88;
Number of Occupations 10;
Total Number of Employees Exposed 4,872;
Total Number of Female Employees Exposed 580


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Glycidol, 1608
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HTOPA*
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as a chemical intermediate

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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