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Registry of Toxic Effects of Chemical Substances (RTECS)

Propanol, (1,1-dimethylethoxy)-

RTECS #

UB3772000

CAS #

57018-52-7

Updated

March 2011

Molecular Weight

132.23

Molecular Formula

C7H16O2

Synonyms

Propanol, tert-butoxy- (8CI)
Propylene glycol t-butyl ether
tert-Butoxypropanol

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1200 ppm/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 199,1,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 150 ppm/17D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightTXCYAC 199,1,2004
inhalation/mouse lowest published toxic concentration: 600 ppm/17D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TXCYAC 199,1,2004
inhalation/mouse lowest published toxic concentration: 1200 ppm/2W- intermittentLiver: Other changes

Liver: Changes in liver weight
TOXID9 78,114,2004
inhalation/mouse lowest published toxic concentration: 1200 ppm/2Y- intermittentLiver: Other changes

Liver: Tumors
TOXID9 78,114,2004
inhalation/mouse lowest published toxic concentration: 1200 ppm/6H/17D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 600 ppm/6H/17D- intermittentLiver: Changes in liver weightNTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 150 ppm/6H/14W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 600 ppm/6H/14W- intermittentLiver: Changes in liver weightNTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 1200 ppm/6H/14W- intermittentLiver: Other changes

Reproductive: Maternal effects: Oogenesis
NTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 600 ppm/6H/14W- intermittentLiver: Other changesNTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 1200 ppm/6H/14W- intermittentOlfaction: TumorsNTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 1200 ppm/6H/104W- intermittentEye: Corneal damage

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-515
inhalation/mouse lowest published toxic concentration: 1200 ppm/6H/104W- intermittentLiver: Other changes

Liver: Tumors
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/6H/26W- intermittentBehavioral: Sleep

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Tumors
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 600 ppm/16D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TXCYAC 199,1,2004
inhalation/rat lowest published toxic concentration: 1200 ppm/16D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TXCYAC 199,1,2004
inhalation/rat lowest published toxic concentration: 600 ppm/16D- intermittentLiver: Changes in liver weightTXCYAC 199,1,2004
inhalation/rat lowest published toxic concentration: 300 ppm/6H/104W- intermittentKidney, Ureter, and Bladder: Kidney tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/6H/104W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 75 ppm/6H/104W- intermittentLiver: Other changes

Liver: Tumors

Kidney, Ureter, and Bladder: Other changes
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/6H/104W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 75 ppm/6H/104W- intermittentOlfaction: Other olfaction effectsNTPTR* TR-515
inhalation/rat lowest published toxic concentration: 600 ppm/6H/14W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/6H/12W- intermittentKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/6H/12W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 75 ppm/6H/2W- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 75 ppm/6H/2W- intermittentLiver: Changes in liver weightNTPTR* TR-515
inhalation/rat lowest published toxic concentration: 300 ppm/6H/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/6H/16D- intermittentKidney, Ureter, and Bladder: Other changesNTPTR* TR-515
inhalation/rat lowest published toxic concentration: 600 ppm/6H/16D- intermittentKidney, Ureter, and Bladder: Changes in kidney weightNTPTR* TR-515
inhalation/rat lowest published toxic concentration: 600 ppm/6H/16D- intermittentLiver: Changes in liver weightNTPTR* TR-515
inhalation/rat lowest published toxic concentration: 1200 ppm/2W- intermittentKidney, Ureter, and Bladder: Other changesTOXID9 78,114,2004
inhalation/rat lowest published toxic concentration: 1200 ppm/2Y- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Bladder tumors
TOXID9 78,114,2004

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review: Group 3IMEMDT 88,436,2006
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWMUREAV 705,184,2010

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2424; Number of Industries 13; Total Number of Facilities 874; Number of Occupations 18; Total Number of Employees Exposed 20356; Total Number of Female Employees Exposed 2551

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000
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