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Propanol, (1,1 - dimethylethoxy) -

RTECS #: UB3772000

CAS #: 57018-52-7


UPDATE: February 2009 MW: 132.23 MF: C7H16O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Propanol, tert - butoxy - (8CI)
  2. Propylene glycol t - butyl ether
  1. tert - Butoxypropanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 199,1,2004


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 150 ppm/17 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight TXCYAC 199,1,2004
inhalation
mouse
lowest published toxic concentration: 600 ppm/17 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TXCYAC 199,1,2004
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/2 week- intermittent Liver: Other changes

Liver: Changes in liver weight
TOXID9 78,114,2004
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/2 year- intermittent Liver: Other changes

Liver: Tumors
TOXID9 78,114,2004
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/6 hour/17 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 600 ppm/6 hour/17 day- intermittent Liver: Changes in liver weight NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 150 ppm/6 hour/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 600 ppm/6 hour/14 week- intermittent Liver: Changes in liver weight NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/6 hour/14 week- intermittent Liver: Other changes

Reproductive: Maternal effects: Oogenesis
NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 600 ppm/6 hour/14 week- intermittent Liver: Other changes NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/6 hour/14 week- intermittent Olfaction: Tumors NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/6 hour/104 week- intermittent Eye: Corneal damage

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-515
inhalation
mouse
lowest published toxic concentration: 1,200 ppm/6 hour/104 week- intermittent Liver: Other changes

Liver: Tumors
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 600 ppm/16 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TXCYAC 199,1,2004
inhalation
rat
lowest published toxic concentration: 1,200 ppm/16 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TXCYAC 199,1,2004
inhalation
rat
lowest published toxic concentration: 600 ppm/16 day- intermittent Liver: Changes in liver weight TXCYAC 199,1,2004
inhalation
rat
lowest published toxic concentration: 1,200 ppm/2 week- intermittent Kidney, Ureter, and Bladder: Other changes TOXID9 78,114,2004
inhalation
rat
lowest published toxic concentration: 1,200 ppm/2 year- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Bladder tumors
TOXID9 78,114,2004
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour/16 day- intermittent Kidney, Ureter, and Bladder: Other changes NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 600 ppm/6 hour/16 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 600 ppm/6 hour/16 day- intermittent Liver: Changes in liver weight NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 600 ppm/6 hour/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour/12 week- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour/12 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/2 week- intermittent Liver: Changes in liver weight NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour/2 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour/104 week- intermittent Kidney, Ureter, and Bladder: Kidney tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour/104 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/104 week- intermittent Liver: Other changes

Liver: Tumors

Kidney, Ureter, and Bladder: Other changes
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour/104 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/104 week- intermittent Olfaction: Other olfaction effects NTPTR* TR-515
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour/26 week- intermittent Behavioral: Sleep

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Tumors
NTPTR* TR-515


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2424;
Number of Industries 13;
Total Number of Facilities 874;
Number of Occupations 18;
Total Number of Employees Exposed 20,356;
Total Number of Female Employees Exposed 2,551


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Tumorigen

Click Here for Additional Information about RTECS

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