Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanol, 1,3-dichloro-

RTECS #

UB1400000

CAS #

96-23-1

Updated

July 2013

Molecular Weight

128.99

Molecular Formula

C3H6Cl2O

Synonyms

1,3-Dichloro-2-propanol
alpha-Dichlorohydrin
Dichlorohydrin
Enodrin
Glycerol alpha,gamma-dichlorohydrin
sym-Dichloroisopropyl alcohol
sym-Glycerol dichlorohydrin
U 25,354

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 10 mg/24H open irritation test mildAIHAAP 23,95,1962

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionHeLa cell/human2500 µmol/LMUREAV 92,427,1982
mutation in microorganisms/Salmonella typhimurium1 µmol/plate (+enzymatic activation step)ENMUDM 2,59,1980
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)SCIEAS 200,785,1978
other mutation test systems/Escherichia coli30 µmol/tubeCBINA8 80,73,1991
sister chromatid exchangelung/hamster250 µmol/LENMUDM 9,401,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1260 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
RTOPDW 53,63,2009
oral/rat 450 mg/kg (13-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)RTOPDW 53,63,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 4550 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** OTS0539378

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 0.3 gm/m3/1HBrain and Coverings: Changes in circulation

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 2,41,1961
inhalation/rat lowest published toxic concentration: 0.3 gm/m3/1HGastrointestinal: Other changes

Liver: Fatty liver degeneration

Liver: Other changes
TPKVAL 2,41,1961
inhalation/rat Lowest published lethal concentration: 125 ppm/4HAIHAAP 23,95,1962
inhalation/rat Lowest published lethal concentration: 660 mg/m3VCVGK* -,191,1994
intraperitoneal/rat lowest published lethal dose: 70 mg/kgBehavioral: Somnolence (general depressed activity)

Liver: Hepatitis (hepatocellular necrosis), zonal
HETOEA 16,262,1997
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 2,41,1961
oral/mouse lowest published lethal dose: 400 mg/kgOlfaction: Other olfaction effectsTPKVAL 2,41,1961
oral/mouse lethal dose (50 percent kill): 25 mg/kgEVHPAZ 69,203,1986
oral/mouse lethal dose (50 percent kill): 93 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,188,1994
oral/rat lethal dose (50 percent kill): 81 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,188,1994
oral/rat lethal dose (50 percent kill): 81 mg/kgVCVGK* -,191,1994
oral/rat lowest published lethal dose: 500 mg/kgGastrointestinal: Necrotic changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 2,41,1961
oral/rat lethal dose (50 percent kill): 0.3 mL/kgBlood: Changes in leukocyte (WBC) countTPKVAL 11,135,1969
oral/rat lowest published toxic dose: 30 mg/kgBehavioral: Food intake (animal)RTOPDW 53,63,2009
skin/rabbit lethal dose (50 percent kill): 590 mg/kgVCVGK* -,191,1994
skin/rabbit lethal dose (50 percent kill): 800 µL/kgAIHAAP 23,95,1962
subcutaneous/mouse lethal dose (50 percent kill): 112.5 mg/kgTPKVAL 2,41,1961

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 170 mg/m3/3H/90D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,188,1994
inhalation/mouse lowest published toxic concentration: 0.24 gm/m3/40D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,41,1961
oral/guinea pig lowest published toxic dose: 910 mg/kg/26W- intermittentBlood: Changes in cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Decreased immune response
VCVGK* -,188,1994
oral/rat lowest published toxic dose: 45.5 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,188,1994
oral/rat lowest published toxic dose: 600 mg/kg/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldRTOPDW 53,63,2009
oral/rat lowest published toxic dose: 420 mg/kg/14D- intermittentBehavioral: Change in motor activity (specific assay)

Liver: Changes in liver weight
RTOPDW 53,63,2009
oral/rat lowest published toxic dose: 14096 mg/kg/2Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0518517

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 48,,2010
TOXICOLOGY REVIEWTXAPA9 243,180,2010
TOXICOLOGY REVIEWMUREAV 751,49,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (2.8 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5378; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 6; Total Number of Employees Exposed 200; Total Number of Female Employees Exposed 6

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP