CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






2 - Propanol, 1,3 - dichloro -

RTECS #: UB1400000

CAS #: 96-23-1


UPDATE: February 2008 MW: 128.99 MF: C3H6Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3 - Dichloro - 2 - propanol
  2. Dichlorohydrin
  3. Enodrin
  4. Glycerol alpha,gamma - dichlorohydrin
  1. U 25,354
  2. alpha - Dichlorohydrin
  3. sym - Dichloroisopropyl alcohol
  4. sym - Glycerol dichlorohydrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
10 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition human HeLa cell 2,500 Ámol/L MUREAV 92,427,1982
mutation in microorganisms Salmonella typhimurium 1 Ámol/plate (+enzymatic activation step) ENMUDM 2,59,1980
mutation in microorganisms Salmonella typhimurium 100 Ág/plate (-enzymatic activation step) SCIEAS 200,785,1978
other mutation test systems Escherichia coli 30 Ámol/tube CBINA8 80,73,1991
sister chromatid exchange hamster lung 250 Ámol/L ENMUDM 9,401,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 4,550 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** OTS0539378


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 0.3 gm/m3/1 hour Brain and Coverings: Changes in circulation

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 2,41,1961
inhalation
rat
lowest published lethal concentration: 125 ppm/4 hour N/R AIHAAP 23,95,1962
inhalation
rat
lowest published lethal concentration: 660 mg/m3 N/R VCVGK* -,191,1994
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/1 hour Gastrointestinal: Other changes

Liver: Fatty liver degeneration

Liver: Other changes
TPKVAL 2,41,1961
intraperitoneal
rat
lowest published lethal dose: 70 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Hepatitis (hepatocellular necrosis), zonal
HETOEA 16,262,1997
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 2,41,1961
oral
mouse
lethal dose (50 percent kill): 25 mg/kg N/R EVHPAZ 69,203,1986
oral
mouse
lethal dose (50 percent kill): 93 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,188,1994
oral
mouse
lowest published lethal dose: 400 mg/kg Olfaction: Other olfaction effects TPKVAL 2,41,1961
oral
rat
lethal dose (50 percent kill): 81 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,188,1994
oral
rat
lethal dose (50 percent kill): 81 mg/kg N/R VCVGK* -,191,1994
oral
rat
lowest published lethal dose: 500 mg/kg Gastrointestinal: Necrotic changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 2,41,1961
oral
rat
lethal dose (50 percent kill): 0.3 mL/kg Blood: Changes in leukocyte (WBC) count TPKVAL 11,135,1969
subcutaneous
mouse
lethal dose (50 percent kill): 112.5 mg/kg N/R TPKVAL 2,41,1961
skin
mouse
lowest published toxic dose: 100 pph Skin: After topical application: Corrosive TPKVAL 2,41,1961
skin
rabbit
lethal dose (50 percent kill): 800 ÁL/kg N/R AIHAAP 23,95,1962
skin
rabbit
lethal dose (50 percent kill): 590 mg/kg N/R VCVGK* -,191,1994
skin
rabbit
lowest published toxic dose: 100 pph/1 hour Skin: After topical application: Primary irritation TPKVAL 2,41,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 170 mg/m3/3 hour/90 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,188,1994
inhalation
mouse
lowest published toxic concentration: 0.24 gm/m3/40 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,41,1961
oral
guinea pig
lowest published toxic dose: 910 mg/kg/26 week- intermittent Blood: Changes in cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Decreased immune response
VCVGK* -,188,1994
oral
rat
lowest published toxic dose: 14,096 mg/kg/2 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0518517
oral
rat
lowest published toxic dose: 45.5 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,188,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5378;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 6;
Total Number of Employees Exposed 200;
Total Number of Female Employees Exposed 6


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for hard resins and NITROCELLULOSE and to manufacture lacquer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent for hard resins and NITROCELLULOSE and to manufacture lacquer

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us