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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Propanol, 2-amino-2-methyl-

RTECS #

UA5950000

CAS #

124-68-5

Updated

December 2010

Molecular Weight

89.16

Molecular Formula

C4H11NO

Synonyms

2-Amino-2-methyl-1-propanol
2-Amino-2-methylpropan-1-ol
2-Amino-2-methylpropanol
2-Aminodimethylethanol
Amp-95
beta-Aminoisobutanol
Isobutanol-2-amine
Isobutanolamine

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 2150 mg/kgJACTDZ 9(2),203,1990
oral/rabbit lowest published lethal dose: 1 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JIHTAB 22,315,1940
oral/rat lethal dose (50 percent kill): 2900 mg/kgJACTDZ 9(2),203,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 100 mg/m3/4H/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJACTDZ 9(2),203,1990
inhalation/monkey lowest published toxic concentration: 6 mg/m3/89D- intermittentLung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JACTDZ 9(2),203,1990
inhalation/rat lowest published toxic concentration: 230 µg/m3/4H/13W- intermittentCardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Changes in uterine weight
JACTDZ 9(2),203,1990
oral/Dog lowest published toxic dose: 11340 mg/kg/28D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JACTDZ 9(2),203,1990
oral/rat lowest published toxic dose: 44800 mg/kg/8W- continuousLiver: Other changes

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(2),203,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXAPA9 243,239,2010

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M5222; Number of Industries 136; Total Number of Facilities 16965; Number of Occupations 94; Total Number of Employees Exposed 219300; Total Number of Female Employees Exposed 54846
National Occupational Hazard Survey 1974Hazard Code M5222; Number of Industries 28; Total Number of Facilities 2958; Number of Occupations 44; Total Number of Employees Exposed 24640

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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