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1 - Propanol, 2 - amino - 2 - methyl -

RTECS #: UA5950000

CAS #: 124-68-5


UPDATE: August 2006 MW: 89.16 MF: C4H11NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Aminodimethylethanol
  2. 2 - Amino - 2 - methylpropanol
  3. 2 - Amino - 2 - methylpropan - 1 - ol
  4. 2 - Amino - 2 - methyl - 1 - propanol
  1. Amp - 95
  2. Isobutanolamine
  3. Isobutanol - 2 - amine
  4. beta - Aminoisobutanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 2,150 mg/kg N/R JACTDZ 9(2),203,1990
oral
rat
lethal dose (50 percent kill): 2,900 mg/kg N/R JACTDZ 9(2),203,1990
oral
rabbit
lowest published lethal dose: 1 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JIHTAB 22,315,1940


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 100 mg/m3/4 hour/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JACTDZ 9(2),203,1990
inhalation
monkey
lowest published toxic concentration: 6 mg/m3/89 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JACTDZ 9(2),203,1990
inhalation
rat
lowest published toxic concentration: 230 g/m3/4 hour/13 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Changes in uterine weight
JACTDZ 9(2),203,1990
oral
dog
lowest published toxic dose: 11,340 mg/kg/28 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JACTDZ 9(2),203,1990
oral
rat
lowest published toxic dose: 44,800 mg/kg/8 week- continuous Liver: Other changes

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JACTDZ 9(2),203,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRIA MAK 4.6 mg/m3 (1 ppm), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 3 ppm (tentative), OCT 2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M5222;
Number of Industries 28;
Total Number of Facilities 2,958;
Number of Occupations 44;
Total Number of Employees Exposed 24,640
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M5222;
Number of Industries 136;
Total Number of Facilities 16,965;
Number of Occupations 94;
Total Number of Employees Exposed 219,300;
Total Number of Female Employees Exposed 54,846


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.

Used as an amine for emulsion and water-soluble polymers, and as a CO2 scavenger

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

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