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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanol, 1-amino-

RTECS #

UA5775000

CAS #

78-96-6

Updated

August 2006

Molecular Weight

75.13

Molecular Formula

C3H9NO

Synonyms

1-Amino-2-propanol
1-Aminopropan-2-ol
1-Methyl-2-aminoethanol
2-Hydroxy-1-propylamine
2-Hydroxypropylamine
alpha-Aminoisopropyl alcohol
Isopropanolamine
Mono-iso-propanolamine
Threamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 970 µg severeUCDS** 5/21/1971
eye /rabbit 250 µg/24H severe85JCAE -,683,1986
skin /rabbit 485 mg open irritation test moderateUCDS** 5/21/1971
skin /rabbit 500 mg/24H mild85JCAE -,683,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
unreported route/rat 280 µg/kg (1D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)TLSMA6 140,79,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 250 mg/kgBehavioral: ExcitementCBCCT* 4,232,1952
oral/rat lethal dose (50 percent kill): 1715 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 30(7),46,1986
skin/mammal (species unspecified) lethal dose (50 percent kill): >1 gm/kgGTPZAB 30(7),46,1986
skin/rabbit lethal dose (50 percent kill): 1640 µL/kgUCDS** 5/21/1971

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83332; Number of Industries 79; Total Number of Facilities 6922; Number of Occupations 80; Total Number of Employees Exposed 132873; Total Number of Female Employees Exposed 13538
National Occupational Hazard Survey 1974Hazard Code 83332; Number of Industries 60; Total Number of Facilities 3204; Number of Occupations 59; Total Number of Employees Exposed 51002

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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