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2 - Propanethiol, 2 - methyl -

RTECS #: TZ7660000

CAS #: 75-66-1


UPDATE: May 2008 MW: 90.20 MF: C4H10S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethanethiol
  2. 2 - Isobutanethiol
  3. 2 - Methyl - 2 - propanethiol
  1. tert - Butanethiol
  2. tert - Butyl mercaptan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
84 mg N/R AIHAAP 19,171,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 16,500 ppm/4 hour Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 19,171,1958
inhalation
rat
lethal concentration (50 percent kill): 22,200 ppm/4 hour Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 19,171,1958
intraperitoneal
rat
lethal dose (50 percent kill): 590 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma
AIHAAP 19,171,1958
oral
rat
lethal dose (50 percent kill): 4,729 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma
AIHAAP 19,171,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 201 ppm/6 hour/2 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
NTIS** OTS0555472


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FRANCE VME 0.5 ppm (1.5 mg/m3), FEB2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0110;
Number of Industries 3;
Total Number of Facilities 321;
Number of Occupations 4;
Total Number of Employees Exposed 4,717


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for manufacturing of pesticides, odorant component, presulfiding agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as intermediate for manufacturing of pesticides, odorant component, presulfiding agent

NIOSH PROFILE (MERCAPTANS), SRC, 10/77

RTECS Compound Description:
   Primary Irritant

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