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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propanethiol, 2-methyl-

RTECS #

TZ7660000

CAS #

75-66-1

Updated

May 2008

Molecular Weight

90.20

Molecular Formula

C4H10S

Synonyms

1,1-Dimethylethanethiol
2-Isobutanethiol
2-Methyl-2-propanethiol
tert-Butanethiol
tert-Butyl mercaptan

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 84 mgAIHAAP 19,171,1958

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 16500 ppm/4HBehavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 19,171,1958
inhalation/rat lethal concentration (50 percent kill): 22200 ppm/4HBehavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 19,171,1958
intraperitoneal/rat lethal dose (50 percent kill): 590 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma
AIHAAP 19,171,1958
oral/rat lethal dose (50 percent kill): 4729 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Behavioral: Coma
AIHAAP 19,171,1958

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 201 ppm/6H/2W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
NTIS** OTS0555472

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FRANCEVME 0.5 ppm (1.5 mg/m3), FEB2006

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code B0110; Number of Industries 3; Total Number of Facilities 321; Number of Occupations 4; Total Number of Employees Exposed 4717

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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