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Propane, 1,2 - epoxy - 3 - isopropoxy -

RTECS #: TZ3500000

CAS #: 4016-14-2


UPDATE: May 2009 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. ( (1 - Methylethoxy) methyl) oxirane
  2. (Isopropoxymethyl) oxirane
  3. 1,2 - Epoxy - 3 - isopropoxypropane
  4. 2,3 - Epoxypropyl isopropyl ether
  5. 3 - Isopropyloxypropylene oxide
  6. Glycidyl isopropyl ether
  1. IGE (OSHA)
  2. Isopropyl epoxypropyl ether
  3. Isopropyl glycidyl ether
  4. Isopropyl glycidyl ether (ACGIH:OSHA)
  5. NCI - C56439
  6. Oxirane, ( (1 - methylethoxy) methyl) - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
92 mg moderate AMIHAB 14,250,1956
eye
rabbit
20 mg/24 hour moderate 85JCAE -,772,1986
skin
rabbit
459 mg/3 day moderate AMIHAB 14,250,1956
skin
rabbit
100 mg/24 hour moderate 85JCAE -,772,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage Escherichia coli 1 Ámol/L ARTODN 46,277,1980
mutation in microorganisms Escherichia coli 20 Ámol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+/-enzymatic activation step) MUREAV 172,105,1986
other mutation test systems Escherichia coli 3,300 Ámol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 2,500 Ámol/L MUREAV 249,55,1991
specific locus test oral
Drosophila melanogaster
2,900 ppm EMMUEG 23,51,1994
heritable translocation test oral
Drosophila melanogaster
2,900 ppm EMMUEG 23,51,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 1,500 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes
AMIHAB 14,250,1956
inhalation
rat
lethal concentration (50 percent kill): 1,100 ppm/8 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes
AMIHAB 14,250,1956
oral
mouse
lethal dose (50 percent kill): 1,300 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral
rat
lethal dose (50 percent kill): 4,200 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
skin
rabbit
lethal dose (50 percent kill): 9,650 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 14,250,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 400 ppm/7 hour/10 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHAB 14,250,1956


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 75 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (240 mg/m3) DTLVS* 3,142,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (238 mg/m3), short term exposure limit 75 ppm (356 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (241 mg/m3), short term exposure limit 75 ppm (361 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (240 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 50 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (240 mg/m3), short term exposure limit 75 ppm (360 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (240 mg/m3);
short term exposure limit 75 ppm (360 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (238 mg/m3);
short term exposure limit 75 ppm (356 mg/m3), JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (240 mg/m3),KZG- week 75 ppm (360 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 30 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm;
short term exposure limit 75 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm;
short term exposure limit 75 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOPROPYL GLYCIDYL ETHER-air ceiling concentration 50 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: Isopropyl glycidyl ether, 1620


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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