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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-

RTECS #

TY6470000

CAS #

77-99-6

Updated

May 2008

Molecular Weight

134.20

Molecular Formula

C6H14O3

Synonyms

1,1,1-Tri(hydroxymethyl)propane
1,1,1-Trimethylolpropane
1,1,1-Tris(hydroxymethyl)propane
2-Ethyl-2-(hydroxymethyl)-1,3-propanediol
Ethriol
Ethyltrimethylolmethane
Ettriol
Hexaglycerine
TMP (alcohol)
Trimethylolpropane
Tris(hydroxymethyl)propane

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 13700 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
HYSAAV 32(5),288,1967
oral/mouse lethal dose (50 percent kill): 14000 mg/kgVCVGK* -,158,1984
oral/rat lethal dose (50 percent kill): 14000 mg/kgVCVGK* -,158,1984
oral/rat lethal dose (50 percent kill): 14100 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
HYSAAV 32(5),288,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1100 mg/m3/4H/106D- intermittentBehavioral: Irritability

Blood: Other changes

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
VCVGK* -,158,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 mg/m3, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83589; Number of Industries 48; Total Number of Facilities 5573; Number of Occupations 43; Total Number of Employees Exposed 74356; Total Number of Female Employees Exposed 12646
National Occupational Hazard Survey 1974Hazard Code 83589; Number of Industries 28; Total Number of Facilities 2495; Number of Occupations 54; Total Number of Employees Exposed 33290

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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