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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3-Propanediol, 2-bromo-2-nitro-

RTECS #

TY3385000

CAS #

52-51-7

Updated

February 2007

Molecular Weight

200.01

Molecular Formula

C3H6BrNO4

Synonyms

2-Bromo-2-nitro-1,3-propanediol
2-Bromo-2-nitropropan-1,3-diol
2-Bromo-2-nitropropane-1,3-diol
2-Bronopol
beta-Bromo-beta-nitrotrimethyleneglycol
Bronidiol
Bronocot
Bronopol
Bronopolu (Polish)
Bronosol
Bronotak

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 5 mgJSCCA5 29,3,1978
skin /human 10 mg moderateJSCCA5 29,3,1978
skin /rabbit 500 mg/24H mildJEPTDQ 4(4),47,1980
skin /rabbit 80 mg moderateJEPTDQ 4(4),47,1980
skin /rat 0.2%VCVGK* -,194,1994

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rabbit 1040 mg/kg (7-19D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FEREAC 67,78459,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/6HPEMNDP 9,103,1991
inhalation/rat lethal concentration (50 percent kill): 800 mg/m3/4HVCVGK* -,193,1994
inhalation/rat lowest published toxic concentration: 5 mg/m3/6HEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea
FEREAC 67,78459,2002
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/4HFEREAC 70,67906,2005
intraperitoneal/mouse lethal dose (50 percent kill): 32.8 mg/kgGastrointestinal: PeritonitisVCVGK* -,193,1994
intraperitoneal/mouse lethal dose (50 percent kill): 15500 µg/kgKHFZAN 11(1),73,1977
intraperitoneal/rat lethal dose (50 percent kill): 22 mg/kgGastrointestinal: PeritonitisVCVGK* -,193,1994
intraperitoneal/rat lethal dose (50 percent kill): 26 mg/kgJSCCA5 29,3,1978
intravenous/mouse lethal dose (50 percent kill): 48 mg/kgIYKEDH 8,680,1977
intravenous/rat lethal dose (50 percent kill): 37400 µg/kgIYKEDH 8,680,1977
oral/Dog lethal dose (50 percent kill): 250 mg/kg28ZEAL 5,30,1976
oral/mouse lethal dose (50 percent kill): 194 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral/mouse lethal dose (50 percent kill): 270 mg/kgPEMNDP 9,103,1991
oral/rabbit lethal dose (50 percent kill): 190 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral/rat lethal dose (50 percent kill): 267 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral/rat lethal dose (50 percent kill): 180 mg/kg28ZEAL 5,30,1976
oral/rat lowest published toxic dose: 80 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
FEREAC 67,78459,2002
oral/rat lethal dose (50 percent kill): 254 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Blood: Changes in spleen
FEREAC 67,78459,2002
oral/rat lethal dose (50 percent kill): 342 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
FEREAC 67,78459,2002
skin/mouse lethal dose (50 percent kill): 4750 mg/kgIYKEDH 8,680,1977
skin/rabbit lowest published toxic dose: 250 mg/kg/8HSkin: After topical application: Primary irritationVCVGK* -,194,1994
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgFEREAC 67,78459,2002
skin/rat lowest published toxic dose: >2000 mg/kg/24HLung, Thorax, or Respiration: Dyspnea

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,78459,2002
skin/rat lethal dose (50 percent kill): 64 mg/kgFEREAC 70,67906,2005
subcutaneous/mouse lethal dose (50 percent kill): 116 mg/kgIYKEDH 8,680,1977
subcutaneous/rat lethal dose (50 percent kill): 200 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
subcutaneous/rat lethal dose (50 percent kill): 170 mg/kgBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
KSRNAM 8,1029,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1800 mg/kg/90D- intermittentGastrointestinal: Nausea or vomitingVCVGK* -,194,1994
oral/Dog lowest published toxic dose: 1820 mg/kg/13W- intermittentGastrointestinal: Nausea or vomitingFEREAC 67,78459,2002
oral/rat lowest published toxic dose: 1800 mg/kg/90D- intermittentGastrointestinal: Other changesFEREAC 70,67906,2005
oral/rat lowest published toxic dose: 7200 mg/kg/90D- intermittentLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,194,1994
oral/rat lowest published toxic dose: 29120 mg/kg/104W- continuousGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Hematuria
FEREAC 67,78459,2002
oral/rat lowest published toxic dose: 116480 mg/kg/104W- continuousKidney, Ureter, and Bladder: Changes primarily in glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,78459,2002
oral/rat lowest published toxic dose: 7280 mg/kg/13W- intermittentLung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,78459,2002
skin/rabbit lowest published toxic dose: 450 mg/kg/90D- intermittentSkin: After topical application: Primary irritationFEREAC 70,67906,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJACTDZ 3(3),139,1984

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,165,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1235; Number of Industries 1; Total Number of Facilities 117; Number of Occupations 5; Total Number of Employees Exposed 5176; Total Number of Female Employees Exposed 4904

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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