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1,3 - Propanediol, 2 - bromo - 2 - nitro -

RTECS #: TY3385000

CAS #: 52-51-7


UPDATE: February 2007 MW: 200.01 MF: C3H6BrNO4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Bromo - 2 - nitro - 1,3 - propanediol
  2. 2 - Bromo - 2 - nitropropan - 1,3 - diol
  3. 2 - Bromo - 2 - nitropropane - 1,3 - diol
  4. 2 - Bronopol
  5. Bronidiol
  6. Bronocot
  1. Bronopol
  2. Bronopolu (Polish)
  3. Bronosol
  4. Bronotak
  5. beta - Bromo - beta - nitrotrimethyleneglycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
5 mg N/R JSCCA5 29,3,1978
skin
human
10 mg moderate JSCCA5 29,3,1978
skin
rat
0.2% VCVGK* -,194,1994
skin
rabbit
500 mg/24 hour mild JEPTDQ 4(4),47,1980
skin
rabbit
80 mg moderate JEPTDQ 4(4),47,1980


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rabbit
lowest published toxic dose: 1,040 mg/kg (7-19 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FEREAC 67,78459,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >5 gm/m3/6 hour N/R PEMNDP 9,103,1991
inhalation
rat
lethal concentration (50 percent kill): 800 mg/m3/4 hour N/R VCVGK* -,193,1994
inhalation
rat
lowest published toxic concentration: 5 mg/m3/6 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea
FEREAC 67,78459,2002
inhalation
rat
lethal concentration (50 percent kill): >5 gm/m3/4 hour N/R FEREAC 70,67906,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 15,500 g/kg N/R KHFZAN 11(1),73,1977
intraperitoneal
mouse
lethal dose (50 percent kill): 32.8 mg/kg Gastrointestinal: Peritonitis VCVGK* -,193,1994
intraperitoneal
rat
lethal dose (50 percent kill): 26 mg/kg N/R JSCCA5 29,3,1978
intraperitoneal
rat
lethal dose (50 percent kill): 22 mg/kg Gastrointestinal: Peritonitis VCVGK* -,193,1994
intravenous
mouse
lethal dose (50 percent kill): 48 mg/kg N/R IYKEDH 8,680,1977
intravenous
rat
lethal dose (50 percent kill): 37,400 g/kg N/R IYKEDH 8,680,1977
oral
dog
lethal dose (50 percent kill): 250 mg/kg N/R 28ZEAL 5,30,1976
oral
mouse
lethal dose (50 percent kill): 270 mg/kg N/R PEMNDP 9,103,1991
oral
mouse
lethal dose (50 percent kill): 194 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral
rat
lethal dose (50 percent kill): 180 mg/kg N/R 28ZEAL 5,30,1976
oral
rat
lethal dose (50 percent kill): 267 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
oral
rat
lowest published toxic dose: 80 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
FEREAC 67,78459,2002
oral
rat
lethal dose (50 percent kill): 254 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Blood: Changes in spleen
FEREAC 67,78459,2002
oral
rat
lethal dose (50 percent kill): 342 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Changes in structure or function of salivary glands
FEREAC 67,78459,2002
oral
rabbit
lethal dose (50 percent kill): 190 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
subcutaneous
mouse
lethal dose (50 percent kill): 116 mg/kg N/R IYKEDH 8,680,1977
subcutaneous
rat
lethal dose (50 percent kill): 170 mg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
KSRNAM 8,1029,1974
subcutaneous
rat
lethal dose (50 percent kill): 200 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
VCVGK* -,193,1994
skin
mouse
lethal dose (50 percent kill): 4,750 mg/kg N/R IYKEDH 8,680,1977
skin
rat
lowest published toxic dose: >2,000 mg/kg/24 hour Lung, Thorax, or Respiration: Dyspnea

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 67,78459,2002
skin
rat
lethal dose (50 percent kill): 64 mg/kg N/R FEREAC 70,67906,2005
skin
rabbit
lowest published toxic dose: 250 mg/kg/8 hour Skin: After topical application: Primary irritation VCVGK* -,194,1994
skin
rabbit
lethal dose (50 percent kill): >2,000 mg/kg N/R FEREAC 67,78459,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 1,800 mg/kg/90 day- intermittent Gastrointestinal: Nausea or vomiting VCVGK* -,194,1994
oral
dog
lowest published toxic dose: 1,820 mg/kg/13 week- intermittent Gastrointestinal: Nausea or vomiting FEREAC 67,78459,2002
oral
rat
lowest published toxic dose: 7,200 mg/kg/90 day- intermittent Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,194,1994
oral
rat
lowest published toxic dose: 29,120 mg/kg/104 week- continuous Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Hematuria
FEREAC 67,78459,2002
oral
rat
lowest published toxic dose: 116,480 mg/kg/104 week- continuous Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,78459,2002
oral
rat
lowest published toxic dose: 7,280 mg/kg/13 week- intermittent Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 67,78459,2002
oral
rat
lowest published toxic dose: 1,800 mg/kg/90 day- intermittent Gastrointestinal: Other changes FEREAC 70,67906,2005
skin
human
lowest published toxic concentration: 0.5 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002
skin
rabbit
lowest published toxic dose: 450 mg/kg/90 day- intermittent Skin: After topical application: Primary irritation FEREAC 70,67906,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JACTDZ 3(3),139,1984


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,165,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1235;
Number of Industries 1;
Total Number of Facilities 117;
Number of Occupations 5;
Total Number of Employees Exposed 5,176;
Total Number of Female Employees Exposed 4,904


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Human Data
   Primary Irritant

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