Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Propanediol

RTECS #

TY2000000

CAS #

57-55-6

Updated

October 2011

Molecular Weight

76.11

Molecular Formula

C3H8O2

Synonyms

1,2-Dihydroxypropane
1,2-Propylene glycol
1,2-Propylenglykol (German)
alpha-Propyleneglycol
Dowfrost
Methylethylene glycol
Monopropylene glycol
PG 12
Propane-1,2-diol
Propylene glycol
Propylene Glycol USP
Sirlene
Solar Winter BAN
Solargard P
Ucar 35

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildFCTOD7 20,573,1982
eye /rabbit 500 mg/24H mild85JCAE -,206,1986
skin /child 30%/96H-continuous moderateJAADDB 42,355,2000
skin /human 500 mg/7D mildJIDEAE 55,190,1970
skin /human 104 mg/3D- intermittent moderate85DKA8 -,127,1977
skin /human 20%CODEDG 57,58,2007
skin /man 10%/2DJIDEAE 19,423,1952
skin /woman 30%/96H open irritation test mildJAADDB 42,355,2000

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysissubcutaneous/mouse8000 mg/kgAPMSBI 274,304,1981
Cytogenetic Analysisfibroblast/hamster32 gm/LFCTOD7 22,623,1984
DNA inhibitionsubcutaneous/mouse8000 mg/kgAPMSBI 274,304,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 100 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)KAIZAN 37,239,1962
intraperitoneal/mouse 100 mg/kg (15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)KAIZAN 37,239,1962

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 684 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): >10000 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 17,717,2003
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.07 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intramuscular/rabbit lowest published lethal dose: 6300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 44,109,1932
intramuscular/rabbit lowest published lethal dose: 6300 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
intramuscular/rat lethal dose (50 percent kill): 20000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intramuscular/rat lethal dose (50 percent kill): 14 gm/kgIAEC** 17JUN1974
intraperitoneal/mouse lethal dose (50 percent kill): 9718 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal/mouse lethal dose (50 percent kill): 11400 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intraperitoneal/rat lowest published toxic dose: 19500 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intraperitoneal/rat lethal dose (50 percent kill): 6660 mg/kgKRKRDT 9,36,1981
intravenous/chicken lowest published lethal dose: 27 gm/kgVascular: Other changesJPETAB 60,312,1937
intravenous/Dog lethal dose (50 percent kill): 26000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
intravenous/Dog lethal dose (50 percent kill): 26 gm/kgNTIS** PB280-477
intravenous/mouse lethal dose (50 percent kill): 6630 mg/kgARZNAD 26,1581,1976
intravenous/mouse lethal dose (50 percent kill): 8000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intravenous/rabbit lowest published lethal dose: 4200 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
intravenous/rabbit lethal dose (50 percent kill): 6500 mg/kgNTIS** PB280-477
intravenous/rat lethal dose (50 percent kill): 6800 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intravenous/rat lethal dose (50 percent kill): 6423 mg/kgARZNAD 26,1581,1976
oral/child lowest published toxic dose: 79 gm/kg/56W- intermittentBrain and Coverings: Changes in surface EEG

Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
JOPDAB 93,515,1978
oral/Dog lethal dose (50 percent kill): 22 gm/kgJIHTAB 21,173,1939
oral/Dog lethal dose (50 percent kill): 22000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
oral/guinea pig lethal dose (50 percent kill): 19000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
oral/guinea pig lethal dose (50 percent kill): 18350 mg/kgJIHTAB 23,259,1941
oral/mouse lethal dose (50 percent kill): 22 gm/kgJPETAB 65,89,1939
oral/mouse lethal dose (50 percent kill): 20300 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
oral/quail lethal dose (50 percent kill): >2080 mg/kgEESADV 6,149,1982
oral/rabbit lowest published lethal dose: 20000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
oral/rabbit lethal dose (50 percent kill): 18500 mg/kgFAONAU 53A,491,1974
oral/rat lethal dose (50 percent kill): 20 gm/kgTXAPA9 45,362,1978
parenteral/infant lowest published toxic dose: 10 gm/kg/3D- continuousNutritional and Gross Metabolic: Other changesPEDIAU 72,353,1983
skin/rabbit lethal dose (50 percent kill): 20800 mg/kgNPIRI* 1,101,1974
skin/rabbit lethal dose (50 percent kill): 20800 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
subcutaneous/guinea pig lowest published lethal dose: 15500 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
subcutaneous/guinea pig lowest published lethal dose: 15500 mg/kgNTIS** PB280-477
subcutaneous/mouse lethal dose (50 percent kill): 17370 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis
KRKRDT 8,46,1981
subcutaneous/mouse lethal dose (50 percent kill): 17400 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
subcutaneous/rat lethal dose (50 percent kill): 28000 mg/kgBehavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
subcutaneous/rat lethal dose (50 percent kill): 22500 mg/kgIAEC** 17JUN1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2180 mg/m3/6H/90D- intermittentBehavioral: Food intake (animal)

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FCTOD7 27,573,1989
intravenous/woman lowest published toxic dose: 5167 mg/kg/13D- continuousNutritional and Gross Metabolic: Changes in: Metabolic acidosisAPHRER 39,1732,2005
oral/Dog lowest published toxic dose: 3650 mg/kg/2Y- intermittentBlood: Normocytic anemia

Blood: Other hemolysis with or without anemia
VCVGK* -,150,1994
oral/rat lowest published toxic dose: 84 mL/kg/30D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,150,1994
oral/rat lowest published toxic dose: 88269 mg/kg/30D- intermittentEndocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TSUMEZ 14,13,1995
skin/human lowest published toxic dose: 5 mg/kg/7D- intermittentSkin: After topical application: Primary irritationVCVGK* -,150,1994
skin/human lowest published toxic dose: 4.5 mg/kg/3D- intermittentSkin: After topical application: Primary irritationVCVGK* -,150,1994
skin/man lowest published toxic dose: 0.03 mL/kg/22D- intermittentSkin: After topical application: Cutaneous sensitization (experimental)CODEDG 8,185,1982
skin/mouse lowest published toxic dose: 1284800 mg/kg/2Y- intermittentSkin and Appendages: TumorsVCVGK* -,150,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,276,1998
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3 (particulates), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 150 ppm (474 mg/m3) (total), JUL2008
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3 (particulates only), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 150 ppm (474 mg/m3) (vapour and particulates), JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 7 mg/m3, JUN2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3 (particulate), OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 150 ppm (474 mg/m3) (total vapor and psrticulate), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 63525; Number of Industries 347; Total Number of Facilities 92966; Number of Occupations 244; Total Number of Employees Exposed 2238429; Total Number of Female Employees Exposed 936584
National Occupational Hazard Survey 1974Hazard Code 63525; Number of Industries 323; Total Number of Facilities 83144; Number of Occupations 224; Total Number of Employees Exposed 1494465

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101108/AS)
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523
On EPA IRIS database
TOP