CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






1,2 - Propanediol

RTECS #: TY2000000

CAS #: 57-55-6


UPDATE: May 2009 MW: 76.11 MF: C3H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Dihydroxypropane
  2. 1,2 - Propylene glycol
  3. 1,2 - Propylenglykol (German)
  4. Dowfrost
  5. Methylethylene glycol
  6. Monopropylene glycol
  7. PG 12
  8. Propane - 1,2 - diol
  1. Propylene Glycol USP
  2. Propylene glycol
  3. Sirlene
  4. Solar Winter BAN
  5. Solargard P
  6. Ucar 35
  7. alpha - Propyleneglycol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild FCTOD7 20,573,1982
eye
rabbit
500 mg/24 hour mild 85JCAE -,206,1986
skin
child
30%/96 hour- continuous moderate JAADDB 42,355,2000
skin
human
500 mg/7 day mild JIDEAE 55,190,1970
skin
human
104 mg/3 day- intermittent moderate 85DKA8 -,127,1977
skin
man
10%/2 day JIDEAE 19,423,1952
skin
woman
30%/96 hour open irritation test mild JAADDB 42,355,2000


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 32 gm/L FCTOD7 22,623,1984
cytogenetic analysis subcutaneous
mouse
8,000 mg/kg APMSBI 274,304,1981
DNA inhibition subcutaneous
mouse
8,000 mg/kg APMSBI 274,304,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) KAIZAN 37,239,1962
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) KAIZAN 37,239,1962


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lethal dose (50 percent kill): 14 gm/kg N/R IAEC** 17JUN1974
intramuscular
rat
lethal dose (50 percent kill): 20,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intramuscular
rabbit
lowest published lethal dose: 6,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 44,109,1932
intramuscular
rabbit
lowest published lethal dose: 6,300 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 9,718 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal
mouse
lethal dose (50 percent kill): 11,400 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intraperitoneal
rat
lethal dose (50 percent kill): 6,660 mg/kg N/R KRKRDT 9,36,1981
intraperitoneal
rat
lowest published toxic dose: 19,500 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intravenous
chicken
lowest published lethal dose: 27 gm/kg Vascular: Other changes JPETAB 60,312,1937
intravenous
dog
lethal dose (50 percent kill): 26 gm/kg N/R NTIS** PB280-477
intravenous
dog
lethal dose (50 percent kill): 26,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
intravenous
mouse
lethal dose (50 percent kill): 6,630 mg/kg N/R ARZNAD 26,1581,1976
intravenous
mouse
lethal dose (50 percent kill): 8,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intravenous
rat
lethal dose (50 percent kill): 6,423 mg/kg N/R ARZNAD 26,1581,1976
intravenous
rat
lethal dose (50 percent kill): 6,800 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
intravenous
rabbit
lethal dose (50 percent kill): 6,500 mg/kg N/R NTIS** PB280-477
intravenous
rabbit
lowest published lethal dose: 4,200 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
oral
child
lowest published toxic dose: 79 gm/kg/56 week- intermittent Brain and Coverings: Changes in surface EEG

Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
JOPDAB 93,515,1978
oral
dog
lethal dose (50 percent kill): 22 gm/kg N/R JIHTAB 21,173,1939
oral
dog
lethal dose (50 percent kill): 22,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
oral
guinea pig
lethal dose (50 percent kill): 18,350 mg/kg N/R JIHTAB 23,259,1941
oral
guinea pig
lethal dose (50 percent kill): 19,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
oral
mouse
lethal dose (50 percent kill): 22 gm/kg N/R JPETAB 65,89,1939
oral
mouse
lethal dose (50 percent kill): 20,300 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
oral
quail
lethal dose (50 percent kill): >2,080 mg/kg N/R EESADV 6,149,1982
oral
rat
lethal dose (50 percent kill): 20 gm/kg N/R TXAPA9 45,362,1978
oral
rabbit
lethal dose (50 percent kill): 18,500 mg/kg N/R FAONAU 53A,491,1974
oral
rabbit
lowest published lethal dose: 20,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
parenteral
infant
lowest published toxic dose: 10 gm/kg/3 day- continuous Nutritional and Gross Metabolic: Other changes PEDIAU 72,353,1983
subcutaneous
guinea pig
lowest published lethal dose: 15,500 mg/kg N/R NTIS** PB280-477
subcutaneous
guinea pig
lowest published lethal dose: 15,500 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984
subcutaneous
mouse
lethal dose (50 percent kill): 17,370 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Cyanosis
KRKRDT 8,46,1981
subcutaneous
mouse
lethal dose (50 percent kill): 17,400 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
subcutaneous
rat
lethal dose (50 percent kill): 22,500 mg/kg N/R IAEC** 17JUN1974
subcutaneous
rat
lethal dose (50 percent kill): 28,000 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,149,1984
skin
human
lowest published toxic concentration: 10 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,125,2002
skin
rabbit
lethal dose (50 percent kill): 20,800 mg/kg N/R NPIRI* 1,101,1974
skin
rabbit
lethal dose (50 percent kill): 20,800 mg/kg Behavioral: Ataxia

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,150,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,180 mg/m3/6 hour/90 day- intermittent Behavioral: Food intake (animal)

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FCTOD7 27,573,1989
intravenous
woman
lowest published toxic dose: 5,167 mg/kg/13 day- continuous Nutritional and Gross Metabolic: Changes in: Metabolic acidosis APHRER 39,1732,2005
oral
dog
lowest published toxic dose: 3,650 mg/kg/2 year- intermittent Blood: Normocytic anemia

Blood: Other hemolysis with or without anemia
VCVGK* -,150,1994
oral
rat
lowest published toxic dose: 88,269 mg/kg/30 day- intermittent Endocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TSUMEZ 14,13,1995
oral
rat
lowest published toxic dose: 84 mL/kg/30 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,150,1994
skin
human
lowest published toxic dose: 5 mg/kg/7 day- intermittent Skin: After topical application: Primary irritation VCVGK* -,150,1994
skin
human
lowest published toxic dose: 4.5 mg/kg/3 day- intermittent Skin: After topical application: Primary irritation VCVGK* -,150,1994
skin
human
lowest published toxic concentration: 10 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002
skin
man
lowest published toxic dose: 0.3 mL/kg/22 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 8,185,1982
skin
mouse
lowest published toxic dose: 1,284,800 mg/kg/2 year- intermittent Skin and Appendages: Tumors VCVGK* -,150,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
HUTOX* -,259,1996
TOXICOLOGY REVIEW
HUTOX* -,623,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,276,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3 (particulates), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 150 ppm (474 mg/m3) (total), JUL2008
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3 (particulates only), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 150 ppm (474 mg/m3) (vapour and particulates), JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 7 mg/m3, JUN2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3 (particulate), 2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 150 ppm (474 mg/m3) (total vapor), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 63525;
Number of Industries 323;
Total Number of Facilities 83,144;
Number of Occupations 224;
Total Number of Employees Exposed 1,494,465
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 63525;
Number of Industries 347;
Total Number of Facilities 92,966;
Number of Occupations 244;
Total Number of Employees Exposed 2,238,429;
Total Number of Female Employees Exposed 936,584


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101108/AS)
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, emulsifier, food, feed additive, flavor, in manufacture of plastics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Glycols, 5523


REFERENCES:

CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
APMSBI Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement. (Copenhagen, Denmark) No.210-274, 1970-81. For publisher information, see ACPADQ.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928-
KRKRDT Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1975-
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TSUMEZ Toxic Substance Mechanisms. (Taylor & Francis, 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.14- 1995-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent, emulsifier, food, feed additive, flavor, in manufacture of plastics

NIOSH PROFILE (GLYCOLS), SRI, 2/77

NIOSH PROFILE (GLYCOLS), SRC, 2/82

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us