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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1,3-dichloro-

RTECS #

TX9660000

CAS #

142-28-9

Updated

December 2012

Molecular Weight

112.99

Molecular Formula

C3H6Cl2

Synonyms

1,3-Dichloropropane
R 270fa
Trimethylene dichloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human500 µmol/LMUREAV 371,185,1996
micronucleus testlymphocyte/human500 µmol/LMUREAV 371,185,1996
mutation in microorganisms/Salmonella typhimurium10 µmol/plate (+/-enzymatic activation step)ENMUDM 2,59,1980
sister chromatid exchangelung/hamster6600 µmol/LENMUDM 9,401,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published lethal dose: 3 gm/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Blood: Hemorrhage
AJHYA2 16,325,1932
unreported route/mouse lethal dose (50 percent kill): 3600 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from small intestine
ESKGA2 28,P31,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 8400 mg/kg/14D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Metabolism (intermediary): Other proteins
JACTDZ 10(4),421,1991
oral/rat lowest published toxic dose: 72 gm/kg/90D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JACTDZ 10(4),421,1991

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 567,347,2004

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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