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Registry of Toxic Effects of Chemical Substances (RTECS)

1,2-Propanediamine

RTECS #

TX6650000

CAS #

78-90-0

Updated

September 199

Molecular Weight

74.15

Molecular Formula

C3H10N2

Synonyms

1,2-Diaminopropane
2,3-Diaminopropane
Propylenediamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 87 mg severeUCDS** 3/12/1969
eye /rabbit 750 µg/24H severe85JCAE -,441,1986
skin /rabbit 10 mg/24H open irritation testAMIHBC 10,61,1954
skin /rabbit 435 mg open irritation test severeUCDS** 3/12/1969
skin /rabbit 5 mg/24H severe85JCAE -,441,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 593 mg/kgYKKZAJ 97,1117,1977
oral/rat lethal dose (50 percent kill): 2230 mg/kgUCDS** 3/12/1969
skin/rabbit lethal dose (50 percent kill): 500 µL/kgAMIHBC 10,61,1954
subcutaneous/rat lowest published lethal dose: 909 mg/kgZEPTAT 17,59,1915

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83465; Number of Industries 3; Total Number of Facilities 122; Number of Occupations 8; Total Number of Employees Exposed 8346; Total Number of Female Employees Exposed 3070
National Occupational Hazard Survey 1974Hazard Code 83465; Number of Industries 7; Total Number of Facilities 118; Number of Occupations 13; Total Number of Employees Exposed 2614

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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