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Propane, 1 - chloro - 2,3 - epoxy -

RTECS #: TX4900000

CAS #: 106-89-8


UPDATE: May 2009 MW: 92.53 MF: C3H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (Chloromethyl) ethylene oxide
  2. (DL) - alpha - Epichlorohydrin
  3. 1,2 - Epoxy - 3 - chloropropane
  4. 1 - Chloor - 2,3 - epoxy - propaan (Dutch)
  5. 1 - Chlor - 2,3 - epoxy - propan (German)
  6. 1 - Chloro - 2,3 - epoxypropane
  7. 1 - Chloro - 2,3 - epoxypropane (OSHA)
  8. 1 - Cloro - 2,3 - epossipropano (Italian)
  9. 2,3 - Epoxypropyl chloride
  10. 2 - (Chloromethyl) oxirane
  11. 3 - Chloro - 1,2 - epoxypropane
  12. 3 - Chloro - 1,2 - propane oxide
  13. 3 - Chloro - 1,2 - propylene oxide
  14. Chloromethyloxirane
  15. Chloropropylene oxide
  16. ECH
  1. Epichloorhydrine (Dutch)
  2. Epichlorhydrin
  3. Epichlorhydrine (French)
  4. Epichlorohydrin
  5. Epichlorohydrin (ACGIH:OSHA)
  6. Epichlorohydryna (Polish)
  7. Epichlorophydrin
  8. Epicloridrina (Italian)
  9. Glycerol epichlorhydrin
  10. Oxirane, (chloromethyl) -
  11. Oxirane, 2 - (chloromethyl)
  12. RCRA waste number U041
  13. Skekhg
  14. alpha - Epichlorohydrin
  15. epi - Chlorohydrin
  16. gamma - Chloropropylene oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe AJOPAA 29,1363,1946
eye
rabbit
100 mg/24 hour moderate 85JCAE -,769,1986
skin
rabbit
10 mg/24 hour open irritation test moderate JIHTAB 30,63,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 15 mg/L MUTAEX 4,432,1989
cytogenetic analysis hamster lung 47 mg/L GMCRDC 27,95,1981
cytogenetic analysis human lymphocyte 10 µmol/L/24 hour STEVA8 11,223,1979
cytogenetic analysis human leukocyte 1 µmol/L MUREAV 34,279,1976
cytogenetic analysis intraperitoneal
mouse
5 mg/kg STEVA8 11,223,1979
cytogenetic analysis oral
mouse
20 mg/kg STEVA8 11,223,1979
cytogenetic analysis inhalation
mouse
5 mg/m3 MUREAV 85,287,1981
cytogenetic analysis rat liver 10 mg/L MUREAV 64,329,1979
DNA damage Bacillus subtilis 20 µL/disc PMRSDJ 1,175,1981
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
DNA damage human mammary gland 2.8 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage mouse lymphocyte 1,040 µmol/L MUREAV 203,155,1988
DNA damage intraperitoneal
mouse
140 mg/kg MUREAV 467,83,2000
DNA damage rat liver 300 µmol/L SinJF# 26OCT1982
DNA damage rat liver 200 µmol/L/3 hour MUREAV 629,49,2007
DNA inhibition human HeLa cell 2,700 µmol/L MUREAV 92,427,1982
DNA inhibition human lymphocyte 5 mmol/L TUMOAB 69,191,1983
DNA repair Bacillus subtilis 997 mmol/L 37ATAD -,155,1977
DNA repair Escherichia coli 4 µg/well MUREAV 133,161,1984
DNA repair Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,502,1981
unscheduled DNA synthesis human fibroblast 32 µg/L PMRSDJ 1,528,1981
unscheduled DNA synthesis human lymphocyte 500 µmol/L TUMOAB 69,191,1983
unscheduled DNA synthesis oral
rat
50 mg/kg CRNGDP 10,1425,1989
host-mediated assay mouse
Salmonella typhimurium
50 mg/kg BIZNAT 95,451,1976
host-mediated assay mouse
Escherichia coli
180 mg/kg MUREAV 272,161,1992
mutation in microorganisms Escherichia coli 1 µL/plate (+/-enzymatic activation step) PMRSDJ 1,387,1981
mutation in microorganisms Klebsiella pneumoniae 200 µmol/L (-enzymatic activation step) MUREAV 89,269,1981
mutation in microorganisms Neurospora crassa 150 mmol/L (-enzymatic activation step) STEVA8 11,223,1979
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
mutation in microorganisms Saccharomyes cerevisiae 40 mg/L (-enzymatic activation step) PMRSDJ 1,414,1981
mutation in microorganisms Schizosaccharomyces pombe 21 mmol/L (-enzymatic activation step) ADWMAX -,193,1962
mutation in microorganisms Schizosaccharomyces pombe 800 µmol/L (+enzymatic activation step) MUREAV 109,41,1983
micronucleus test intraperitoneal
mouse
120 mg/kg/16 day- intermittent 54DEAI -,175,1984
micronucleus test multiple
non-mammalian species
10,800 nmol/L MUTAEX 4,17,1989
gene conversion and mitotic recombination Saccharomyes cerevisiae 65 mmol/L IJEBA6 18,1337,1980
mutation in mammalian somatic cells hamster ovary 30 mg/L MUREAV 136,137,1984
mutation in mammalian somatic cells human other cell types 500 µmol/L TUMOAB 69,191,1983
mutation in mammalian somatic cells mouse lymphocyte 7,500 µg/L PMRSDJ 1,580,1981
morphological transform hamster kidney 25 mg/L PMRSDJ 1,638,1981
other mutation test systems Bacillus subtilis 1 mole/L 37ATAD -,155,1977
other mutation test systems Escherichia coli 195 nmol/tube MUREAV 147,79,1985
other mutation test systems Salmonella typhimurium 60 mg/L MUREAV 192,239,1987
sister chromatid exchange hamster ovary 33 µL/L PMRSDJ 1,551,1981
sister chromatid exchange hamster lung 100 mg/L CNREA8 44,3270,1984
sister chromatid exchange human lymphocyte 10 nmol/L CARYAB 34,261,1981
sister chromatid exchange intraperitoneal
mouse
5,500 µg/kg PMRSDJ 1,673,1981
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
5,100 µmol/L EVSRBT 24,175,1981
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,468,1981
sperm morphology inhalation
mouse
5 mg/m3 MUREAV 85,287,1981
sperm morphology oral
rat
50 mg/kg ARTODN 53,71,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 50 ppm/6 hour (50 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 68,415,1983
inhalation
rat
lowest published toxic concentration: 100 ppm/7 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0545225
inhalation
rabbit
lowest published toxic concentration: 100 ppm/7 hour (6-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0545225
oral
mouse
lowest published toxic dose: 1,200 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 9,87,1982
oral
rat
lowest published toxic dose: 180 mg/kg (12 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NATUAS 226,87,1970
oral
rat
lowest published toxic dose: 25 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ARTODN 53,71,1983
oral
rat
lowest published toxic dose: 1,050 mg/kg (21 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
FAATDF 13,16,1989
oral
rat
lowest published toxic dose: 288 mg/kg (23 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JOAND3 12,54,1991
subcutaneous
rat
lowest published toxic dose: 75 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXAPA9 70,67,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour/30 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Acute pulmonary edema
JJIND8 65,751,1980
inhalation
rat
toxic concentration (other than lowest) : 100 ppm/6 hour/6 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PAACA3 21,106,1980
inhalation
rat
toxic concentration (other than lowest) : 100 ppm Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
CHWKA9 123(24),25,1978
inhalation
rat
toxic concentration (other than lowest) : 30 ppm/6 hour/57 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
JJIND8 65,751,1980
intraperitoneal
mouse
lowest published toxic dose: 2,400 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXAPA9 82,19,1986
oral
rat
lowest published toxic dose: 60 gm/kg/81 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
GANNA2 71,922,1980
oral
rat
toxic dose : 36 gm/kg/81 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
GANNA2 71,922,1980
oral
rat
toxic dose : 85,050 mg/kg/81 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NAIZAM 32,270,1981
oral
rat
toxic dose : 42,525 mg/kg/81 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NAIZAM 32,270,1981
oral
rat
toxic dose : 5,150 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Tumors
TXCYAC 36,325,1985
subcutaneous
mouse
lowest published toxic dose: 720 mg/kg/18 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 48,1431,1972
subcutaneous
mouse
toxic dose : 2,760 mg/kg/69 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 53,695,1974
unreported route
mouse
lowest published toxic dose: 19 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 40 ppm/2 hour Lung, Thorax, or Respiration: Other changes 34ZIAG -,240,1969
inhalation
human
lowest published toxic concentration: 20 ppm Olfaction: Other olfaction effects

Eye: Other eye effects
29ZWAE -,108,1968
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1 gm/m3 Lung, Thorax, or Respiration: Respiratory depression TPKVAL 7,76,1965
inhalation
mouse
lowest published lethal concentration: 72 gm/m3/9 minute N/R JBMRBG 8,11,1974
inhalation
mouse
lethal concentration : 3.25 gm/m3/2 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 2,28,1961
inhalation
mouse
lethal concentration : 5.25 gm/m3/2 hour Skin: After systemic exposure: Dermatitis, other TPKVAL 2,28,1961
inhalation
mouse
lethal concentration (50 percent kill): 3 gm/m3/2 hour Gastrointestinal: Necrotic changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 2,28,1961
inhalation
rat
lethal concentration (50 percent kill): 250 ppm/8 hour N/R ENTOX* -,228,2005
inhalation
rat
lowest published toxic concentration: 0.7 gm/m3/4 hour Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
TPKVAL 12,33,1971
inhalation
rat
lowest published toxic concentration: 0.35 gm/m3/4 hour Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section
TPKVAL 12,33,1971
inhalation
rat
lethal concentration : 3.25 gm/m3/2 hour Eye: Miosis (pupilliary constriction)

Eye: Lacrimation

Eye: Corneal damage
TPKVAL 2,28,1961
inhalation
rat
lethal concentration (50 percent kill): 3 gm/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Ataxia

Cardiac: Cardiomyopathy including infarction
TPKVAL 2,28,1961
inhalation
rat
lowest published lethal concentration: 3 gm/m3 Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Gastrointestinal: Necrotic changes
TPKVAL 7,76,1965
inhalation
rat
lowest published lethal concentration: 3 gm/m3 Liver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 7,76,1965
intraperitoneal
guinea pig
lethal dose (50 percent kill): 118 mg/kg N/R JPMSAE 61,1712,1972
intraperitoneal
mouse
lethal dose (50 percent kill): 170 mg/kg N/R JPMSAE 61,1712,1972
intraperitoneal
rat
lethal dose (50 percent kill): 113 mg/kg N/R JPMSAE 61,1712,1972
intraperitoneal
rabbit
lethal dose (50 percent kill): 160 mg/kg N/R JPMSAE 61,1712,1972
intravenous
rat
lethal dose (50 percent kill): 154 mg/kg N/R NPIRI* 1,41,1974
ocular
mammal (species unspecified)
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 7,76,1965
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 2,28,1961
oral
guinea pig
lethal dose (50 percent kill): 280 mg/kg N/R GISAAA 33(1),46,1968
oral
mammal (species unspecified)
lowest published toxic dose: 350 mg/kg N/R TPKVAL 7,76,1965
oral
mouse
lethal dose (50 percent kill): 195 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
GISAAA 33(1),46,1968
oral
mouse
lethal dose (50 percent kill): 236 mg/kg N/R ENTOX* -,228,2005
oral
rat
lethal dose (50 percent kill): 90 mg/kg N/R ENTOX* -,228,2005
oral
rabbit
lethal dose (50 percent kill): 345 mg/kg N/R GISAAA 33(1),46,1968
subcutaneous
mouse
lowest published lethal dose: 250 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 2,28,1961
subcutaneous
mouse
lethal dose (70 percent kill): 250 mg/kg Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
TPKVAL 2,28,1961
subcutaneous
rat
lethal dose (50 percent kill): 150 mg/kg Kidney, Ureter, and Bladder: Urine volume increased AMPMAR 28,505,1967
skin
mammal (species unspecified)
lowest published toxic dose: 100 pph Skin: After topical application: Corrosive TPKVAL 7,76,1965
skin
mouse
lethal dose (50 percent kill): 250 mg/kg N/R 85GMAT -,64,1982
skin
mouse
lethal dose : 100 pph/1 hour N/R TPKVAL 2,28,1961
skin
rat
lowest published lethal dose: 1 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
UCPHAQ 2,69,1941
skin
rabbit
lethal dose (50 percent kill): 515 mg/kg N/R WolMA# 18JAN1977
skin
rabbit
lowest published toxic dose: 100 pph/1 hour Skin: After topical application: Primary irritation TPKVAL 2,28,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 25 ppm/6 hour/90 day- intermittent Olfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects

Liver: Other changes
NTIS** OTS0555021
inhalation
mouse
lowest published toxic concentration: 1 gm/m3/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 20 mg/m3/24 hour/14 week- continuous Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Blood: Other changes
GISAAA 31(9),7,1966
inhalation
rat
lowest published toxic concentration: 5 ppm/2 hour/5 week- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
HOCHE8 12,144,1994
inhalation
rat
lowest published toxic concentration: 170 mg/m3/3 hour/17 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 1 gm/m3/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 0.21 gm/m3/45 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 0.21 gm/m3/30 day- intermittent Behavioral: Somnolence (general depressed activity)

Vascular: Other changes

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/182 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/61 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Vascular: BP elevation not characterized in autonomic section
TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/91 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TPKVAL 2,28,1961
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/197 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TPKVAL 2,28,1961
intraperitoneal
wild bird
lowest published toxic dose: 60 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field IJEBA6 37,774,1999
intraperitoneal
mouse
lowest published toxic dose: 120 mg/kg/16 day- intermittent Blood: Normocytic anemia

Blood: Microcytosis with or without anemia
NTIS** OTS0542017
intraperitoneal
rat
lowest published toxic dose: 341 µg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JPMSAE 61,1712,1972
intraperitoneal
rat
lowest published toxic dose: 2,045 µg/kg/12 week- intermittent Brain and Coverings: Changes in brain weight

Behavioral: Food intake (animal)

Blood: Changes in other cell count (unspecified)
JPMSAE 61,1712,1972
oral
rat
lowest published toxic dose: 190 mg/kg/10 day- intermittent Gastrointestinal: Alteration in gastric secretion

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 19,41,1996
oral
rat
lowest published toxic dose: 1,218 mg/kg/9 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Biochemical: Metabolism (intermediary): Other proteins
GISAAA 33(1),46,1968
oral
rat
lowest published toxic dose: 910 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 33(1),46,1968
oral
rabbit
lowest published toxic dose: 4,872 mg/kg/9 week- intermittent Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
GISAAA 33(1),46,1968
oral
rabbit
lowest published toxic dose: 91 mg/kg/9 week- intermittent Liver: Liver function tests impaired

Blood: Changes in other cell count (unspecified)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
GISAAA 33(1),46,1968
subcutaneous
rat
lowest published toxic dose: 270 mg/kg/9 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes
WDZAEK 6,270,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 11,131,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,603,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,202,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,603,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,603,1999
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
ENTOX* -,228,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (19 mg/m3) (skin) DTLVS* 3,98,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (7.6 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRIA TRK 12 mg/m3 (3 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (1.9 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (1.9 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VLE 2 ppm (10 mg/m3), continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK (skin, sen), 2005
Occupational Exposure Limit - HUNGARY ceiling concentration 1.9 mg/m3, Skin, Carcinogen, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (10 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 ppm (10 mg/m3);
short term exposure limit 5 ppm (20 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.9 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (1.9 mg/m3);
short term exposure limit 1.5 ppm (5.8 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm (1.9 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (19 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, short term exposure limit 8 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 ppm (1.9 mg/m3);
short term exposure limit 1 ppm (4 mg/m3), Skin, Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (8 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (19 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (1.9 mg/m3);
short term exposure limit 1.5 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EPICHLOROHYDRIN-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 29010;
Number of Industries 40;
Total Number of Facilities 2,004;
Number of Occupations 58;
Total Number of Employees Exposed 41,380
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 29010;
Number of Industries 75;
Total Number of Facilities 4,249;
Number of Occupations 87;
Total Number of Employees Exposed 80,170;
Total Number of Female Employees Exposed 14,921


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-human; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the production of synthetic GLYCERIN, unmodified epoxy resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 30, 1978
NIOSH Analytical Method, 1994: Epichlorohydrin, 1010
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
37ATAD "Prevention and Detection of Cancer, Proceedings of the 3rd International Symposium on Detection and Prevention of Cancer," New York, Marcel Dekker, 1977
54DEAI "Occupational Health in the Chemical Industry, Proceedings of the International Congress, 11th, Alberta, Canada, 1983," Oxford, R.R., et al., eds., Calgary, Alberta, Canada, Univ. of Calgary, 1984
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued.
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHWKA9 Chemical Week. (McGraw-Hill, Inc., 1221 Ave. of the Americas, New York, NY 10020) V.68- 1951-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
HOCHE8 Hochudoku. (Nippon Hochudoku Gakkai, c/o Kyushu Daigaku Igakubu Hoigaku Kyoshitsu, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan) V.8- 1990-
HTOPA*
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
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RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCPHAQ University of California, Berkeley, Publications in Pharmacology. (Berkeley, CA) V.1-3, 1938-57. Discontinued.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
WolMA# Personal Communication from M.A. Wolf, Dow Chemical Co., Midland, MI 48640, Jan. 18, 1977

Used in the production of synthetic GLYCERIN, unmodified epoxy resins

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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