Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1-bromo-3-chloro-

RTECS #

TX4113000

CAS #

109-70-6

Updated

April 2012

Molecular Weight

157.45

Molecular Formula

C3H6BrCl

Synonyms

1,3-Chbp
1-Bromo-3-chloropropane
3-Bromopropyl chloride
3-Chloropropyl bromide
omega-Chlorobromopropane
Trimethylene bromide chloride
Trimethylene chlorobromide

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 7270 mg/m3/2H85GMAT -,35,1982
inhalation/rat lethal concentration (50 percent kill): 6500 mg/m3/4HVCVGH* -,653,1990
inhalation/rat lethal concentration (50 percent kill): 5668 mg/m3GTPZAB 19(9),36,1975
inhalation/rat lethal concentration (50 percent kill): 7.27 gm/m3/4HSkin: After systemic exposure: Dermatitis, irritativeTPKVAL 12,93,1971
inhalation/rat lethal concentration (50 percent kill): 6.5 gm/m3/4HEye: Change in extra- ocular muscles

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 12,93,1971
inhalation/rat lowest published toxic concentration: 0.41 gm/m3TPKVAL 12,93,1971
inhalation/rat Lowest published lethal concentration: 7.8 gm/m3/4HLiver: Changes in liver weightTPKVAL 12,93,1971
inhalation/rat Lowest published lethal concentration: 6.8 gm/m3/4HEye: Conjunctiva irritationTPKVAL 12,93,1971
ocular/rabbit lowest published toxic dose: 100 pphBrain and Coverings: Changes in circulation

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor
TPKVAL 12,93,1971
oral/mouse lethal dose (50 percent kill): 1290 mg/kg85GMAT -,35,1982
oral/rat lethal dose (50 percent kill): 930 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy)

Behavioral: Analgesia
TPKVAL 12,93,1971
oral/rat lethal dose (50 percent kill): 1100 mg/kgBrain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Cardiac: Other changes
TPKVAL 12,93,1971
oral/rat lethal dose (16 percent kill): 940 mg/kgLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TPKVAL 12,93,1971
oral/rat lowest published lethal dose: 1290 mg/kgTPKVAL 12,93,1971
unreported route/rat lethal dose (50 percent kill): 930 mg/kgVCVGH* -,653,1990

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP