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Propane, 1 - bromo - 3 - chloro -

RTECS #: TX4113000

CAS #: 109-70-6


UPDATE: February 2008 MW: 157.45 MF: C3H6BrCl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. STANDARDS AND REGULATIONS:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. 1,3 - Chbp
  2. 1 - Bromo - 3 - chloropropane
  3. 3 - Bromopropyl chloride
  4. 3 - Chloropropyl bromide
  1. Trimethylene bromide chloride
  2. Trimethylene chlorobromide
  3. omega - Chlorobromopropane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 7,270 mg/m3/2 hour N/R 85GMAT -,35,1982
inhalation
rat
lethal concentration (50 percent kill): 5,668 mg/m3 N/R GTPZAB 19(9),36,1975
inhalation
rat
lethal concentration (50 percent kill): 6,500 mg/m3/4 hour N/R VCVGH* -,653,1990
inhalation
rat
lethal concentration (50 percent kill): 7.27 gm/m3/4 hour Skin: After systemic exposure: Dermatitis, irritative TPKVAL 12,93,1971
inhalation
rat
lethal concentration : 6.8 gm/m3/4 hour Eye: Conjunctiva irritation TPKVAL 12,93,1971
inhalation
rat
lethal concentration : 7.8 gm/m3/4 hour Liver: Changes in liver weight TPKVAL 12,93,1971
inhalation
rat
lethal concentration (50 percent kill): 6.5 gm/m3/4 hour Eye: Change in extra- ocular muscles

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 12,93,1971
inhalation
rat
lowest published toxic concentration: 0.41 gm/m3 N/R TPKVAL 12,93,1971
ocular
rabbit
lowest published toxic dose: 100 pph Brain and Coverings: Changes in circulation

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor
TPKVAL 12,93,1971
oral
mouse
lethal dose (50 percent kill): 1,290 mg/kg N/R 85GMAT -,35,1982
oral
rat
lethal dose (50 percent kill): 1,100 mg/kg Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Cardiac: Other changes
TPKVAL 12,93,1971
oral
rat
lethal dose (16 percent kill): 940 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TPKVAL 12,93,1971
oral
rat
lethal dose : 1,290 mg/kg N/R TPKVAL 12,93,1971
oral
rat
lethal dose (50 percent kill): 930 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy)

Behavioral: Analgesia
TPKVAL 12,93,1971
skin
mouse
lowest published toxic dose: 100 pph/4 hour Gastrointestinal: Changes in structure or function of salivary glands TPKVAL 12,93,1971
unreported route
rat
lethal dose (50 percent kill): 930 mg/kg N/R VCVGH* -,653,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as pharmaceutical intermediates
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as pharmaceutical intermediates

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

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