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Propane, 1 - bromo -

RTECS #: TX4110000

CAS #: 106-94-5


UPDATE: February 2009 MW: 123.01 MF: C3H7Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Bromopropane
  2. Propyl bromide
  1. n - Propyl bromide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human leukocyte 0.1 mmol/L/8 hour TOXID9 78,31,2004
DNA damage human leukocyte 1 mmol/L/4 hour MUREAV 603,1,2006
DNA damage inhalation
human
5 ppm/1 week MUREAV 603,1,2006
DNA damage Saccharomyes cerevisiae 6,750 mg/L/17 hour MUREAV 633,80,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 821 ppm/8 hour (12 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) SAIGBL 40,414,1998
inhalation
rat
lowest published toxic concentration: 200 ppm/8 hour (12 week male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands TOSCF2 54,416,2000
inhalation
rat
lowest published toxic concentration: 100 ppm/8 hour (1 day pregnant-22 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) TOXID9 44,57,2005
inhalation
rat
lowest published toxic concentration: 800 ppm/8 hour (1-22 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 44,57,2005
inhalation
rat
lowest published toxic concentration: 800 ppm/8 hour (1-22 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 44,57,2005
inhalation
rat
lowest published toxic dose: 200 ppm (2 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 78,174,2004
inhalation
rat
lowest published toxic concentration: 800 ppm (2 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 78,174,2004
inhalation
rat
lowest published toxic concentration: 1,000 ppm (8 hour male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOXID9 78,403,2004
inhalation
rat
lowest published toxic concentration: 798 ppm (1 day pregnant-2 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 798 ppm (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 393 ppm (1 day pregnant-21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 101 ppm (1 day pregnant-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 816 ppm (1-21 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 816 ppm (1-7 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 816 ppm (1-20 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Delayed effects
TXCYAC 224,219,2006
oral
rat
lowest published toxic dose: 2 gm/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) MUREAV 101,321,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 7,100 mg/m3 N/R VCVGH* -,593,1990
inhalation
rat
lethal concentration (50 percent kill): 253 gm/m3/30 minute N/R FAVUAI 7,35,1975
inhalation
rat
lethal concentration (50 percent kill): 19,700 mg/m3 N/R VCVGH* -,593,1990
inhalation
rat
lowest published toxic concentration: 700 ppm/6 hour Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 134,237,2002
inhalation
rat
lowest published toxic concentration: 1,000 ppm/8 hour Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,403,2004
intraperitoneal
mouse
lethal dose (50 percent kill): 1,210 mg/kg N/R VCVGH* -,572,1990
intraperitoneal
rat
lethal dose (50 percent kill): 2,950 mg/kg N/R 85GMAT -,102,1982
oral
mouse
lethal dose (50 percent kill): 4,700 mg/kg N/R VCVGH* -,593,1990
oral
rat
lowest published lethal dose: 4 gm/kg N/R MUREAV 101,321,1982
oral
rat
lethal dose (50 percent kill): 3,600 mg/kg N/R VCVGH* -,593,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 108 ppm/7 hour/3 year- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Peripheral Nerve and Sensation: Paresthesia

Nutritional and Gross Metabolic: Changes in: Cl
CTOXAO 45,270,2007
inhalation
man
lowest published toxic concentration: 108 ppm/7 hour/91 day- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia
CTOXAO 45,270,2007
inhalation
rat
lowest published toxic concentration: 98,408 mg/m3/30 minute/1 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
JPETAB 80,139,1944
inhalation
rat
lowest published toxic concentration: 1,800 ppm/6 hour/8 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
SAIGBL 41,A42,1999
inhalation
rat
lowest published toxic concentration: 400 ppm/8 hour/12 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath TOXID9 54,394,2000
inhalation
rat
lowest published toxic concentration: 200 ppm/8 hour/12 week- intermittent Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NRTXDN 24,199,2003
inhalation
rat
lowest published toxic concentration: 400 ppm/8 hour/12 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 24,199,2003
inhalation
rat
lowest published toxic concentration: 800 ppm/8 hour/12 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
NRTXDN 24,199,2003
inhalation
rat
lowest published toxic concentration: 800 ppm/3 week- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 71,96,2003
inhalation
rat
lowest published toxic concentration: 200 ppm/12 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Maternal effects: Oogenesis
TOSCF2 71,96,2003
inhalation
rat
lowest published toxic concentration: 700 ppm/6 hour/8 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
LIFSAK 72,521,2002
inhalation
rat
lowest published toxic concentration: 1,500 ppm/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 134,237,2002
inhalation
rat
lowest published toxic concentration: 700 ppm/8 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 134,237,2002
inhalation
rat
lowest published toxic concentration: 1,500 ppm/4 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 134,237,2002
inhalation
rat
lowest published toxic concentration: 700 ppm/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 134,237,2002
inhalation
rat
lowest published toxic concentration: 1,500 ppm/3 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 134,237,2002
inhalation
rat
lowest published toxic concentration: 200 ppm/8 hour/2 week- intermittent Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 78,174,2004
inhalation
rat
lowest published toxic concentration: 800 ppm/8 hour/2 week- intermittent Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,174,2004
inhalation
rat
lowest published toxic concentration: 200 ppm/7 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes
TOXID9 60,370,2001
inhalation
rat
lowest published toxic concentration: 200 ppm/7 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes TOXID9 60,370,2001
inhalation
rat
lowest published toxic concentration: 800 ppm/7 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOXID9 60,370,2001
inhalation
rat
lowest published toxic concentration: 200 ppm/12 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 60,371,2001
inhalation
rat
lowest published toxic concentration: 400 ppm/12 week- intermittent Biochemical: Metabolism (intermediary): Other TOXID9 60,371,2001
inhalation
rat
lowest published toxic concentration: 800 ppm/12 week- intermittent Biochemical: Metabolism (intermediary): Other proteins TOXID9 60,371,2001
inhalation
rat
lowest published toxic concentration: 798 ppm/21 day- intermittent Blood: Hemorrhage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 224,219,2006
inhalation
rat
lowest published toxic concentration: 400 ppm/12 week- intermittent Brain and Coverings: Other degenerative changes NRTXDN 28,381,2007
inhalation
rat
lowest published toxic concentration: 400 ppm/8 week- intermittent Brain and Coverings: Other degenerative changes NRTXDN 28,270,2007
intraperitoneal
mouse
lowest published toxic dose: 1,350 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes SAIGBL 40,415,1998
multiple
human
lowest published toxic concentration: 70 pph/91 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Muscle weakness

Behavioral: Headache
JTCTDW 41,729,2003
oral
rat
lowest published toxic dose: 560 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,26,2003
oral
rat
lowest published toxic dose: 1,960 mg/kg/7 week- continuous Reproductive: Maternal effects: Menstrual cycle changes or disorders TOXID9 72,26,2003
oral
rat
lowest published toxic dose: 1,680 mg/kg/12 week- continuous Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TOXID9 72,26,2003
unreported route
rat
lowest published toxic dose: 37,887 mg/kg/4 week- intermittent Autonomic Nervous System: Ganglion blocker

Behavioral: Somnolence (general depressed activity)
SAIGBL 41,A1,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (51 mg/m3), MAR2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
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   Mutagen
   Reproductive Effector
   Human Data

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