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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 1-bromo-

RTECS #

TX4110000

CAS #

106-94-5

Updated

September 201

Molecular Weight

123.01

Molecular Formula

C3H7Br

Synonyms

1-Bromopropane
n-Propyl bromide
Propyl bromide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageleukocyte/human0.1 mmol/L/8HTOXID9 78,31,2004
DNA Damageleukocyte/human1 mmol/L/4HMUREAV 603,1,2006
DNA Damageinhalation/human5 ppm/1WMUREAV 603,1,2006
DNA Damage/Saccharomyes cerevisiae6750 mg/L/17HMUREAV 633,80,2007

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 821 ppm/8H (12W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)SAIGBL 40,414,1998
inhalation/rat 200 ppm/8H (12W male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsTOSCF2 54,416,2000
inhalation/rat 100 ppm/8H (1D preg-22D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TOXID9 44,57,2005
inhalation/rat 800 ppm/8H (1-22D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 44,57,2005
inhalation/rat 800 ppm/8H (1-22D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 44,57,2005
inhalation/rat 200 ppm (2W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTOXID9 78,174,2004
inhalation/rat 800 ppm (2W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TOXID9 78,174,2004
inhalation/rat 1000 ppm (8H male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOXID9 78,403,2004
inhalation/rat 798 ppm (1D preg-2D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)TXCYAC 224,219,2006
inhalation/rat 798 ppm (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXCYAC 224,219,2006
inhalation/rat 393 ppm (1D preg-21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TXCYAC 224,219,2006
inhalation/rat 101 ppm (1D preg-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTXCYAC 224,219,2006
inhalation/rat 816 ppm (1-21D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 224,219,2006
inhalation/rat 816 ppm (1-7D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TXCYAC 224,219,2006
inhalation/rat 816 ppm (1-20D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Delayed effects
TXCYAC 224,219,2006
oral/rat 2 gm/kg (5D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)MUREAV 101,321,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
FCTOD7 50,1616,2012
In Vitro/Human, melanoma Inhibitor Concentration Low: 1 µmol/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationFCTOD7 50,1616,2012
inhalation/mouse lethal concentration (50 percent kill): 7100 mg/m3VCVGH* -,593,1990
inhalation/rat lethal concentration (50 percent kill): 19700 mg/m3VCVGH* -,593,1990
inhalation/rat lethal concentration (50 percent kill): 253 gm/m3/30MFAVUAI 7,35,1975
inhalation/rat lowest published toxic concentration: 700 ppm/6HLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 134,237,2002
inhalation/rat lowest published toxic concentration: 1000 ppm/8HEndocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,403,2004
intraperitoneal/mouse lethal dose (50 percent kill): 1210 mg/kgVCVGH* -,572,1990
intraperitoneal/rat lethal dose (50 percent kill): 2950 mg/kg85GMAT -,102,1982
oral/mouse lethal dose (50 percent kill): 4700 mg/kgVCVGH* -,593,1990
oral/mouse lowest published toxic dose: 200 mg/kgLiver: Other changes

Blood: Changes in spleen
JAPTO* 27,358,2007
oral/mouse lowest published toxic dose: 1000 mg/kgLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JAPTO* 27,358,2007
oral/rat lethal dose (50 percent kill): 3600 mg/kgVCVGH* -,593,1990
oral/rat lowest published lethal dose: 4 gm/kgMUREAV 101,321,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 108 ppm/7H/3Y- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Peripheral Nerve and Sensation: Paresthesia

Nutritional and Gross Metabolic: Changes in: Cl
JTCTDW 45,270,2007
inhalation/man lowest published toxic concentration: 108 ppm/7H/91D- intermittentBehavioral: Muscle weakness

Behavioral: Ataxia
JTCTDW 45,270,2007
inhalation/rat lowest published toxic concentration: 400 ppm/12W- intermittentBrain and Coverings: Other degenerative changesNRTXDN 28,381,2007
inhalation/rat lowest published toxic concentration: 400 ppm/8W- intermittentBrain and Coverings: Other degenerative changesNRTXDN 28,270,2007
inhalation/rat lowest published toxic concentration: 400 ppm/4W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
NRTXDN 30,1078,2009
inhalation/rat lowest published toxic concentration: 800 ppm/8H/4W- intermittentBrain and Coverings: Other degenerative changesTXCYAC 285,67,2011
inhalation/rat lowest published toxic concentration: 98408 mg/m3/30M/1W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
JPETAB 80,139,1944
inhalation/rat lowest published toxic concentration: 1800 ppm/6H/8W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
SAIGBL 41,A42,1999
inhalation/rat lowest published toxic concentration: 400 ppm/8H/12W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheathTOXID9 54,394,2000
inhalation/rat lowest published toxic concentration: 200 ppm/8H/12W- intermittentSpinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NRTXDN 24,199,2003
inhalation/rat lowest published toxic concentration: 400 ppm/8H/12W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 24,199,2003
inhalation/rat lowest published toxic concentration: 800 ppm/8H/12W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
NRTXDN 24,199,2003
inhalation/rat lowest published toxic concentration: 800 ppm/3W- intermittentReproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 71,96,2003
inhalation/rat lowest published toxic concentration: 200 ppm/12W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Maternal effects: Oogenesis
TOSCF2 71,96,2003
inhalation/rat lowest published toxic concentration: 700 ppm/6H/8W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
LIFSAK 72,521,2002
inhalation/rat lowest published toxic concentration: 1500 ppm/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOLED5 134,237,2002
inhalation/rat lowest published toxic concentration: 700 ppm/8W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOLED5 134,237,2002
inhalation/rat lowest published toxic concentration: 1500 ppm/4W- intermittentBehavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 134,237,2002
inhalation/rat lowest published toxic concentration: 700 ppm/4W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 134,237,2002
inhalation/rat lowest published toxic concentration: 1500 ppm/3W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOLED5 134,237,2002
inhalation/rat lowest published toxic concentration: 200 ppm/8H/2W- intermittentEndocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 78,174,2004
inhalation/rat lowest published toxic concentration: 800 ppm/8H/2W- intermittentEndocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,174,2004
inhalation/rat lowest published toxic concentration: 200 ppm/7D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes
TOXID9 60,370,2001
inhalation/rat lowest published toxic concentration: 200 ppm/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesTOXID9 60,370,2001
inhalation/rat lowest published toxic concentration: 800 ppm/7D- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOXID9 60,370,2001
inhalation/rat lowest published toxic concentration: 200 ppm/12W- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 60,371,2001
inhalation/rat lowest published toxic concentration: 400 ppm/12W- intermittentBiochemical: Metabolism (intermediary): OtherTOXID9 60,371,2001
inhalation/rat lowest published toxic concentration: 800 ppm/12W- intermittentBiochemical: Metabolism (intermediary): Other proteinsTOXID9 60,371,2001
inhalation/rat lowest published toxic concentration: 798 ppm/21D- intermittentBlood: Hemorrhage

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 224,219,2006
inhalation/woman lowest published toxic concentration: 2.92 ppm/118W- intermittentTaste: Change in function

Behavioral: Somnolence (general depressed activity)
TOXID9 -,169,2009
intraperitoneal/mouse lowest published toxic dose: 1350 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changesSAIGBL 40,415,1998
multiple/human lowest published toxic concentration: 70 pph/91D- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Muscle weakness

Behavioral: Headache
JTCTDW 41,729,2003
oral/rat lowest published toxic dose: 560 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 72,26,2003
oral/rat lowest published toxic dose: 1960 mg/kg/7W- continuousReproductive: Maternal effects: Menstrual cycle changes or disordersTOXID9 72,26,2003
oral/rat lowest published toxic dose: 1680 mg/kg/12W- continuousReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TOXID9 72,26,2003
unreported route/rat lowest published toxic dose: 37887 mg/kg/4W- intermittentAutonomic Nervous System: Ganglion blocker

Behavioral: Somnolence (general depressed activity)
SAIGBL 41,A1,1999

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWREPTED 31,392,2011
TOXICOLOGY REVIEWREPTED 33,269,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (51 mg/m3), MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (50 mg/m3), short term exposure limit 50 ppm (250 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 ppm (10.3 mg/m3), MAY2012

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
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