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Registry of Toxic Effects of Chemical Substances (RTECS)

Propane, 2,2-bis(p-(2,3-epoxypropoxy)phenyl)-

RTECS #

TX3800000

CAS #

1675-54-3

Updated

August 2009

Molecular Weight

340.45

Molecular Formula

C21H24O4

Synonyms

2,2'-((1-Methylethylidene)bis(4,1-phenyleneoxymethylene))bisoxirane
2,2-Bis(4-(2,3-epoxypropyloxy)phenyl)propane
2,2-Bis(4-hydroxyphenyl)propane, diglycidyl ether
2,2-Bis(p-glycidyloxyphenyl)propane
2,2-Bis(p-hydroxyphenyl)propane, diglycidyl ether
4,4'-Dihydroxydiphenyldimethylmethane diglycidyl ether
4,4'-Isopropylidenediphenol diglycidyl ether
BADGE
Bis(4-glycidyloxyphenyl)dimethyamethane
Bis(4-hydroxyphenyl)dimethylmethane diglycidyl ether
Bisphenol A diglycidyl ether
Bpdge
D.E.R. 332
Dian diglycidyl ether
Dian-bis-glycidylether (Czech)
Diglycidyl bisphenol A ether
Diglycidyl ether of 2,2-bis(4-hydroxyphenyl)propane
Diglycidyl ether of 2,2-bis(p-hydroxyphenyl)propane
Diglycidyl ether of 4,4'-isopropylidenediphenol
Diglycidyl ether of bisphenol A
Diomethane diglycidyl ether
Epi-Rez 508
Epi-Rez 510
Epotuf 37-140
Epoxide A
ERL-2774
GY 6010
Oligomer 340
p,p'-Dihydroxydiphenyldimethylmethane diglycidyl ether

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 2 mg/24H severe85JCAE -,782,1986
skin /rabbit 500 mg open irritation test mildUCDS** 4/21/1967

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductskin/mouse20 gm/LCRNGDP 13,969,1992
micronucleus testlymphocyte/human12.5 mg/L/3H (-enzymatic activation step)MUREAV 536,39,2003
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+/-enzymatic activation step)MUTAEX 16,303,2001
mutation in microorganisms/Escherichia coli2000 µg/plate (+/-enzymatic activation step)MUREAV 609,11,2006
mutation in microorganisms/Escherichia coli100 µg/plate (-enzymatic activation step)MUREAV 609,11,2006
mutation in microorganisms/Escherichia coli250 µg/plate (+enzymatic activation step)MUREAV 609,11,2006
mutation in microorganisms/Salmonella typhimurium50 µg/plate/72H (-enzymatic activation step)MUTAEX 16,303,2001
mutation in microorganisms/Salmonella typhimurium100 µg/plate/72H (+enzymatic activation step)MUTAEX 16,303,2001
mutation in microorganisms/Salmonella typhimurium0.1 mg/plate (-enzymatic activation step)MUREAV 536,39,2003
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)MUREAV 172,105,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 166 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
FCTOD7 26,611,1988
skin/mouse toxic dose: 312 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors
CNREA8 39,1718,1979
skin/mouse toxic dose: 312 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
NTIS** ORNL-5375

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 4 gm/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2219,1981
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationBJPCBM 151,844,2007
intraperitoneal/rat lethal dose (50 percent kill): 2200 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2219,1981
oral/mouse lethal dose (50 percent kill): 15600 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2219,1981
oral/rabbit lethal dose (50 percent kill): 1980 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2219,1981
oral/rat lethal dose (50 percent kill): 11300 µL/kgUCDS** 4/21/1967
skin/rabbit lethal dose (50 percent kill): 20 gm/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
38MKAJ 2A,2219,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 4100 mg/kg/13W- intermittentSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0558858
skin/rat lowest published toxic dose: 52 gm/kg/2Y- intermittentLiver: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0559600
skin/rat lowest published toxic dose: 68 gm/kg/13W- intermittentBehavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0558862

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 47,237,1989
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1285,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1285,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 47,237,1989

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3 (total dust), 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83440; Number of Industries 28; Total Number of Facilities 1109; Number of Occupations 38; Total Number of Employees Exposed 25257; Total Number of Female Employees Exposed 4341
National Occupational Hazard Survey 1974Hazard Code T0018; Number of Industries 8; Total Number of Facilities 163; Number of Occupations 10; Total Number of Employees Exposed 1413
National Occupational Hazard Survey 1974Hazard Code 83440; Number of Industries 54; Total Number of Facilities 2505; Number of Occupations 54; Total Number of Employees Exposed 32393

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
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