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Registry of Toxic Effects of Chemical Substances (RTECS)

Potassium pyrosulfite

RTECS #

TT4920000

CAS #

16731-55-8

Updated

December 2011

Molecular Weight

222.32

Molecular Formula

O5S2·K2

Synonyms

Dipotassium disulfite
Dipotassium metabisulfite
Disulfurous acid, dipotassium salt (9CI)
Potassium disulfite
Potassium metabisulfite
Pyrosulfurous acid, dipotassium salt

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human25 mg/L/24HEMMUEG 49,276,2008
Cytogenetic Analysisintraperitoneal/rat150 mg/kgEMMUEG 49,276,2008
micronucleus testlymphocyte/human25 mg/L/24HEMMUEG 49,276,2008
sister chromatid exchangelymphocyte/human25 mg/L/24HEMMUEG 49,276,2008
Unscheduled DNA Synthesisoral/rat400 mg/kgJJCREP 80,424,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 35 gm/kg (49D prior to copulation/1-21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)CRSBAW 172,470,1978

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 54,131,1992
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 54,131,1992
TOXICOLOGY REVIEWIJTOFN 22,63,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82177; Number of Industries 34; Total Number of Facilities 4265; Number of Occupations 45; Total Number of Employees Exposed 33335; Total Number of Female Employees Exposed 10193
National Occupational Hazard Survey 1974Hazard Code 82177; Number of Industries 17; Total Number of Facilities 1935; Number of Occupations 13; Total Number of Employees Exposed 5348

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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