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Registry of Toxic Effects of Chemical Substances (RTECS)

Potassium nitrite (1:1)

RTECS #

TT3750000

CAS #

7758-09-0

Updated

January 1997

Molecular Weight

85.11

Molecular Formula

NO2·K

Synonyms

Nitrous acid, potassium salt

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibition/Other microorganisms20 mmol/LJMOBAK 5,442,1962
mutation in microorganisms/Salmonella typhimurium3300 µg/plate (+/-enzymatic activation step)MUREAV 260,321,1991
mutation in microorganisms/Other microorganisms500 mmol/L (-enzymatic activation step)JMOBAK 9,352,1964
mutation in microorganisms/Other microorganisms500 mmol/L (-enzymatic activation step)JOVIAM 7,673,1971
mutation in microorganisms/Other microorganisms20 mmol/L (-enzymatic activation step)JMOBAK 5,442,1962

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 30 gm/kg (60D male/60D prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)DABSAQ 28,3815,1968
oral/guinea pig 137 gm/kg (18W prior to copulation)Reproductive: Effects on newborn: StillbirthTXAPA9 12,179,1968
oral/guinea pig 201 gm/kg (19W prior to copulation)Reproductive: Effects on fertility: Abortion

Reproductive: Other effects to embryo or fetus
TXAPA9 12,179,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 85 gm/m3/2HBehavioral: Sleep

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GISAAA 48(1),62,1983
oral/human lowest published toxic dose: 1428 µg/kgEar: Tinnitus

Cardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section
GISAAA 48(1),62,1983
oral/rabbit lethal dose (50 percent kill): 200 mg/kgSOVEA7 27,246,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 18 gm/kg/13W- continuousBlood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 26,851,1988

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83413; Number of Industries 22; Total Number of Facilities 788; Number of Occupations 34; Total Number of Employees Exposed 27303; Total Number of Female Employees Exposed 2845
National Occupational Hazard Survey 1974Hazard Code 83413; Number of Industries 11; Total Number of Facilities 205; Number of Occupations 7; Total Number of Employees Exposed 1353

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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