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Registry of Toxic Effects of Chemical Substances (RTECS)

Potassium nitrate

RTECS #

TT3700000

CAS #

7757-79-1

Updated

December 2010

Molecular Weight

179.31

Molecular Formula

KNO3·K

Synonyms

Collo-Bo
Kaliumnitrat (German)
Niter
Nitre
Nitric acid, potassium salt
Saltpeter
Vicknite

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Escherichia coli5 pphJGMIAN 8,45,1953

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 22 gm/kg (1-22D pregnant)Reproductive: Effects on fertility: Other measures of fertilityJANSAG 15,1291,1956
oral/rat 598 mg/kg (1-22D preg/5D after birth)Reproductive: Effects on newborn: BehavioralAPHHDU 74,69,1989
oral/rabbit 6505 mg/kg (23-27D pregnant)Reproductive: Effects on fertility: AbortionSOVEA7 27,246,1974
oral/guinea pig 15 gm/kg (24W prior to copulation)Reproductive: Effects on newborn: StillbirthTXAPA9 12,179,1968
oral/guinea pig 1670 gm/kg (29W prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Other effects to embryo or fetus
TXAPA9 12,179,1968

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/cat lowest published lethal dose: 100 mg/kgHBAMAK 4,1289,1935
oral/rabbit lethal dose (50 percent kill): 1901 mg/kgSOVEA7 27,246,1974
oral/rat lethal dose (50 percent kill): 3540 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,49,1993
oral/rat lowest published toxic dose: 10 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,49,1993
oral/rat lethal dose (50 percent kill): 3750 mg/kgNYKZAU 81,469,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 36 gm/kg/90D- intermittentGastrointestinal: Other changesBECTA6 60,185,1998
oral/rat lowest published toxic dose: 2250 mg/kg/150D- intermittentEndocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 147,27,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXAPA9 243,180,2010

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,318,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80350; Number of Industries 67; Total Number of Facilities 4503; Number of Occupations 65; Total Number of Employees Exposed 66562; Total Number of Female Employees Exposed 26088
National Occupational Hazard Survey 1974Hazard Code 80350; Number of Industries 67; Total Number of Facilities 4730; Number of Occupations 53; Total Number of Employees Exposed 36204

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8804
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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