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Potassium nitrate

RTECS #: TT3700000

CAS #: 7757-79-1


UPDATE: May 2006 MW: 179.31 MF: KNO3ĽK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Collo - Bo
  2. Kaliumnitrat (German)
  3. Niter
  4. Nitre
  1. Nitric acid, potassium salt
  2. Saltpeter
  3. Vicknite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
gene conversion and mitotic recombination Escherichia coli 5 pph JGMIAN 8,45,1953


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
guinea pig
lowest published toxic dose: 15 gm/kg (24 week prior to copulation) Reproductive: Effects on newborn: Stillbirth TXAPA9 12,179,1968
oral
guinea pig
lowest published toxic dose: 1,670 gm/kg (29 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Other effects to embryo or fetus
TXAPA9 12,179,1968
oral
rat
lowest published toxic dose: 22 gm/kg (1-22 day pregnant) Reproductive: Effects on fertility: Other measures of fertility JANSAG 15,1291,1956
oral
rat
lowest published toxic dose: 598 mg/kg (1-22 day pregnant/5 day after birth) Reproductive: Effects on newborn: Behavioral APHHDU 74,69,1989
oral
rabbit
lowest published toxic dose: 6,505 mg/kg (23-27 day pregnant) Reproductive: Effects on fertility: Abortion SOVEA7 27,246,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
cat
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1289,1935
oral
rat
lethal dose (50 percent kill): 3,750 mg/kg N/R NYKZAU 81,469,1983
oral
rat
lethal dose (50 percent kill): 3,540 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,49,1993
oral
rat
lowest published toxic dose: 10 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,49,1993
oral
rabbit
lethal dose (50 percent kill): 1,901 mg/kg N/R SOVEA7 27,246,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 36 gm/kg/90 day- intermittent Gastrointestinal: Other changes BECTA6 60,185,1998
oral
rat
lowest published toxic dose: 2,250 mg/kg/150 day- intermittent Endocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 147,27,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,318,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80350;
Number of Industries 67;
Total Number of Facilities 4,730;
Number of Occupations 53;
Total Number of Employees Exposed 36,204
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80350;
Number of Industries 67;
Total Number of Facilities 4,503;
Number of Occupations 65;
Total Number of Employees Exposed 66,562;
Total Number of Female Employees Exposed 26,088


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in fireworks, fluxes, glass manufacture, matches, gunpowders, and as a diuretic
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8804
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

APHHDU Acta Physiologica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) V.61- 1983-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SOVEA7 Southwestern Veterinarian. (College of Veterinary Medicine, Texas A & M Univ., College Station, TX 77843) V.1- 1948-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in fireworks, fluxes, glass manufacture, matches, gunpowders, and as a diuretic

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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