UPDATE: May 2009

MW: 39.10

MF: K

NOTE:

• TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.
  

TABLE OF CONTENTS:

1. ACUTE TOXICITY DATA:
   
2. OTHER MULTIPLE DOSE DATA:
   
3. REVIEWS:
   
4. NIOSH DOCUMENTATION AND SURVEILLANCE:
   
5. STATUS IN FEDERAL AGENCIES:
   
6. REFERENCES:
   

SYNONYMS:
N/R	N/R

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 700 mg/kg	N/R	85IXA4 -,704,1948

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 169.2 mg/kg/180 day- continuous	Cardiac: Changes in heart weight Gastrointestinal: Other changes Blood: Changes in cell count (unspecified)	VCVN1* -,36,1988
oral rat	lowest published toxic dose: 157.5 mg/kg/12 week- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Effect on mitochondrial function Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS	VCVN1* -,36,1988

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		ENTOX* -,520,2005
TOXICOLOGY REVIEW		HTOPA* 1,595,2002

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 60315; Number of Industries 12; Total Number of Facilities 443; Number of Occupations 18; Total Number of Employees Exposed 6,148
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 60315; Number of Industries 25; Total Number of Facilities 1,202; Number of Occupations 32; Total Number of Employees Exposed 39,061; Total Number of Female Employees Exposed 19,402

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID121

REFERENCES:
CODEN	REFERENCE
85IXA4	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HTOPA*
VCVN1*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

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