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Polyvinyl alcohol

RTECS #: TR8100000

CAS #: 9002-89-5


UPDATE: February 2008 MW: N/R MF: (C2H4O)x


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Alcotex 88/05
  2. Alcotex 88/10
  3. Alkotex
  4. Alvyl
  5. Aracet APV
  6. Cipoviol W 72
  7. Covol
  8. Covol 971
  9. EP 160
  10. Elvanol
  11. Elvanol 50 - 42
  12. Elvanol 52 - 22
  13. Elvanol 70 - 05
  14. Elvanol 71 - 30
  15. Elvanol 90 - 50
  16. Elvanol 522 - 22
  17. Elvanol 73125G
  18. Ethenol homopolymer (9CI)
  19. GH 20
  20. GL 02
  21. GL 03
  22. GLO 5
  23. GM 14
  24. Galvatol 1 - 60
  25. Gelvatol
  26. Gelvatol 1 - 30
  27. Gelvatol 1 - 90
  28. Gelvatol 3 - 91
  29. Gelvatol 20 - 30
  30. Gelvatol 2090
  31. Gohsenol
  32. Gohsenol AH 22
  33. Gohsenol GH
  34. Gohsenol GH 17
  35. Gohsenol GH 20
  36. Gohsenol GH 23
  37. Gohsenol GL 03
  38. Gohsenol GL 05
  39. Gohsenol GL 08
  40. Gohsenol GM 14
  41. Gohsenol GM 94
  42. Gohsenol GM 14L
  43. Gohsenol KH 17
  44. Gohsenol NH 05
  45. Gohsenol NH 17
  46. Gohsenol NH 18
  47. Gohsenol NH 20
  48. Gohsenol NH 26
  49. Gohsenol NK 114
  50. Gohsenol NL 05
  51. Gohsenol NM 14
  52. Ivalon
  53. Kuralon VP
  54. Kurare poval 1700
  55. Kurare PVA 205
  56. Kurate poval 120
  57. Lemol
  58. Lemol 12 - 88
  59. Lemol 16 - 98
  1. Lemol 24 - 98
  2. Lemol 30 - 98
  3. Lemol 5 - 88
  4. Lemol 5 - 98
  5. Lemol 51 - 98
  6. Lemol 60 - 98
  7. Lemol 75 - 98
  8. Lemol GF - 60
  9. M 13/20
  10. Mowiol
  11. Mowiol N 30 - 88
  12. Mowiol N 50 - 98
  13. Mowiol N 70 - 98
  14. NH 18
  15. NM 11
  16. NM 14
  17. PVA 008
  18. PVS 4
  19. Polydesis
  20. Polysizer 173
  21. Polyvinol
  22. Polyviol
  23. Polyviol M 13/140
  24. Polyviol MO 5/140
  25. Polyviol W 25/140
  26. Polyviol W 40/140
  27. Poval 117
  28. Poval 120
  29. Poval 1700
  30. Poval 203
  31. Poval 205
  32. Poval 217
  33. Poval C 17
  34. Resistoflex
  35. Rhodoviol
  36. Rhodoviol 4/125
  37. Rhodoviol 16/200
  38. Rhodoviol 4 - 125P
  39. Rhodoviol R 16/20
  40. Solvar
  41. Sumitex H 10
  42. Vibatex S
  43. Vinacol MH
  44. Vinalak
  45. Vinarol
  46. Vinarol DT
  47. Vinarole
  48. Vinarol ST
  49. Vinavilol 2 - 98
  50. Vinnarol
  51. Vinol
  52. Vinol 125
  53. Vinol 205
  54. Vinol 351
  55. Vinol 523
  56. Vinol unisize
  57. Vinyl alcohol polymer
  58. Vinylon film 2000


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
rat
lowest published toxic dose: 10 gm/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Immunological Including Allergic: Increase in cellular immune response
BJSUAM 52,49,1965
implant
rat
toxic dose : 3,768 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
EXPEAM 19,424,1963
subcutaneous
rat
lowest published toxic dose: 2,500 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
AMPLAO 67,589,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 2,000 mg/kg N/R FCTOD7 41,405,2003
intratracheal
rat
lowest published toxic dose: 108.7 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TPKVAL 5,136,1963
oral
mouse
lethal dose (50 percent kill): 14,700 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
GISAAA 51(10),75,1986
oral
mouse
lethal dose (50 percent kill): >4,000 mg/kg N/R FCTOD7 41,405,2003
oral
mouse
lethal dose : 5,000 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
TPKVAL 5,136,1963
oral
rat
lethal dose (50 percent kill): >20 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
GISAAA 51(10),75,1986
rectal
mouse
lethal dose (50 percent kill): >1,000 mg/kg N/R FCTOD7 41,405,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 45 mg/m3/2 hour/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,136,1963
oral
rat
lowest published toxic dose: 22,500 mg/kg/45 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 51(10),75,1986
oral
rat
lowest published toxic dose: 315 gm/kg/90 day- continuous Gastrointestinal: Hypermotility, diarrhea FCTOD7 41,719,2003
oral
rat
lowest published toxic dose: 315 gm/kg/90 day- continuous Liver: Changes in liver weight FCTOD7 41,719,2003
oral
rat
lowest published toxic dose: 70 gm/kg/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,729,2003
oral
rat
lowest published toxic dose: 140 gm/kg/70 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 66,375,2002
oral
rat
lowest published toxic dose: 15,000 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,136,1963
oral
rat
lowest published toxic dose: 5,500 mg/kg/11 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 5,136,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,341,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,341,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
EMMUEG 39,69,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81944;
Number of Industries 159;
Total Number of Facilities 17,615;
Number of Occupations 98;
Total Number of Employees Exposed 124,708
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8571;
Number of Industries 181;
Total Number of Facilities 25,435;
Number of Occupations 133;
Total Number of Employees Exposed 500,947;
Total Number of Female Employees Exposed 183,064


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a textile warp sizing and finishing agent, and a component of adhesives
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (intravaginal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS.
BJSUAM British Journal of Surgery. (Quadrant Subscription Services Ltd., Oakfield House, Perrymount Rd., Haywards Heath, W. Sussex RH16 3DH, UK) V.1- 1913-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as a textile warp sizing and finishing agent, and a component of adhesives

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen

Click Here for Additional Information about RTECS

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