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Registry of Toxic Effects of Chemical Substances (RTECS)

Polyvinyl alcohol

RTECS #

TR8100000

CAS #

9002-89-5

Updated

April 2012

Molecular Weight

N/R

Molecular Formula

(C2H4O)x

Synonyms

Alcotex 88/05
Alcotex 88/10
Alkotex
Alvyl
Aracet APV
Cipoviol W 72
Covol
Covol 971
Elvanol
Elvanol 50-42
Elvanol 52-22
Elvanol 522-22
Elvanol 70-05
Elvanol 71-30
Elvanol 73125G
Elvanol 90-50
EP 160
Ethenol homopolymer (9CI)
Galvatol 1-60
Gelvatol
Gelvatol 1-30
Gelvatol 1-90
Gelvatol 20-30
Gelvatol 2090
Gelvatol 3-91
GH 20
GL 02
GL 03
GLO 5
GM 14
Gohsenol
Gohsenol AH 22
Gohsenol GH
Gohsenol GH 17
Gohsenol GH 20
Gohsenol GH 23
Gohsenol GL 03
Gohsenol GL 05
Gohsenol GL 08
Gohsenol GM 14
Gohsenol GM 14L
Gohsenol GM 94
Gohsenol KH 17
Gohsenol NH 05
Gohsenol NH 17
Gohsenol NH 18
Gohsenol NH 20
Gohsenol NH 26
Gohsenol NK 114
Gohsenol NL 05
Gohsenol NM 14
Ivalon
Kuralon VP
Kurare poval 1700
Kurare PVA 205
Kurate poval 120
Lemol
Lemol 12-88
Lemol 16-98
Lemol 24-98
Lemol 30-98
Lemol 51-98
Lemol 5-88
Lemol 5-98
Lemol 60-98
Lemol 75-98
Lemol GF-60
M 13/20
Mowiol
Mowiol N 30-88
Mowiol N 50-98
Mowiol N 70-98
NH 18
NM 11
NM 14
Polydesis
Polysizer 173
Polyvinol
Polyviol
Polyviol M 13/140
Polyviol MO 5/140
Polyviol W 25/140
Polyviol W 40/140
Poval 117
Poval 120
Poval 1700
Poval 203
Poval 205
Poval 217
Poval C 17
PVA 008
PVS 4
Resistoflex
Rhodoviol
Rhodoviol 16/200
Rhodoviol 4/125
Rhodoviol 4-125P
Rhodoviol R 16/20
Solvar
Sumitex H 10
Vibatex S
Vinacol MH
Vinalak
Vinarol
Vinarol DT
Vinarol ST
Vinarole
Vinavilol 2-98
Vinnarol
Vinol
Vinol 125
Vinol 205
Vinol 351
Vinol 523
Vinol unisize
Vinyl alcohol polymer
Vinylon film 2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 10 gm/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Immunological Including Allergic: Increase in cellular immune response
BJSUAM 52,49,1965
implant/rat toxic dose: 3768 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
EXPEAM 19,424,1963
subcutaneous/rat lowest published toxic dose: 2500 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
AMPLAO 67,589,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 2000 mg/kgFCTOD7 41,405,2003
intratracheal/rat lowest published toxic dose: 108.7 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
TPKVAL 5,136,1963
oral/mouse lowest published lethal dose: 5000 mg/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes
TPKVAL 5,136,1963
oral/mouse lethal dose (50 percent kill): 14700 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
GISAAA 51(10),75,1986
oral/mouse lethal dose (50 percent kill): >4000 mg/kgFCTOD7 41,405,2003
oral/rat lethal dose (50 percent kill): >20 gm/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
GISAAA 51(10),75,1986
rectal/mouse lethal dose (50 percent kill): >1000 mg/kgFCTOD7 41,405,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 45 mg/m3/2H/15D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,136,1963
oral/rat lowest published toxic dose: 15000 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 5,136,1963
oral/rat lowest published toxic dose: 5500 mg/kg/11D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 5,136,1963
oral/rat lowest published toxic dose: 22500 mg/kg/45D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GISAAA 51(10),75,1986
oral/rat lowest published toxic dose: 315 gm/kg/90D- continuousGastrointestinal: Hypermotility, diarrheaFCTOD7 41,719,2003
oral/rat lowest published toxic dose: 315 gm/kg/90D- continuousLiver: Changes in liver weightFCTOD7 41,719,2003
oral/rat lowest published toxic dose: 70 gm/kg/5W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 41,729,2003
oral/rat lowest published toxic dose: 140 gm/kg/70D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 66,375,2002

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 19,341,1979
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 19,341,1979
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWEMMUEG 39,69,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X8571; Number of Industries 181; Total Number of Facilities 25435; Number of Occupations 133; Total Number of Employees Exposed 500947; Total Number of Female Employees Exposed 183064
National Occupational Hazard Survey 1974Hazard Code 81944; Number of Industries 159; Total Number of Facilities 17615; Number of Occupations 98; Total Number of Employees Exposed 124708

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (intravaginal);no evidence:mouse
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