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Registry of Toxic Effects of Chemical Substances (RTECS)

Poly(1-(2-oxo-1-pyrrolidinyl)ethylene)iodine complex

RTECS #

TR1579600

CAS #

25655-41-8; 9006-37-5

Updated

October 2012

Molecular Weight

N/R

Molecular Formula

(C6H9NO)n·xI

Synonyms

1-Vinyl-2-pyrrolidinone polymer, compd. with iodine
2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine
Betadine
Efo-dine
Isodine
Polyvinylpyrrolidone, iodine complex
Povidone-iodine
PVP-iodine
Ultradine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 5%/48HCODEDG 42,90,2000
skin /rabbit 500 mg mildYACHDS 17(Suppl 1),75,1989
skin /woman 10% severeINJPD2 41,199,2009
skin /woman 1%CODEDG 60,348,2009
skin /woman 1%/10D- intermittent open irritation testCODEDG 60,348,2009

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/human200 ppmJTEHD6 1,977,1976
DNA repair/Escherichia coli1 µL/discJPMSAE 64,1235,1975
morphological transformlymphocyte/mouse5000 ppmAPTOD9 19,A106,1980
mutation in mammalian somatic cellslymphocyte/mouse5000 ppmAPTOD9 19,A106,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat 1450 mg/kg (15-22D preg/3W after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
KSRNAM 22,4663,1988
subcutaneous/rat 11600 mg/kg (15-22D preg/3W after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
KSRNAM 22,4663,1988
subcutaneous/rat 11600 mg/kg (15-22D preg/3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
KSRNAM 22,4663,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jteInhibitor Concentration Low: 0.125 gm/L/24HIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 279,130,2011
In Vitro/jteInhibitor Concentration Low: 0.55 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 279,130,2011
In Vitro/jteInhibitor Concentration Low: 2 gm/L/24HIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TXCYAC 279,130,2011
intravenous/mouse lethal dose (50 percent kill): 480 mg/kgNIIRDN 6,788,1982
intravenous/rat lethal dose (50 percent kill): 640 mg/kgNIIRDN 6,788,1982
oral/mouse lethal dose (50 percent kill): 8100 mg/kgNIIRDN 6,788,1982
oral/rat lethal dose (50 percent kill): >8 gm/kgNIIRDN 6,788,1982
skin/guinea pig lowest published toxic dose: 8 mg/kgSkin: After systemic exposure: Dermatitis, irritative

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
ARTODN 76,119,2002
skin/human lowest published toxic dose: 3400 mg/kg/24HBlood: Hemorrhage

Skin: After systemic exposure: Dermatitis, other
JAMAAP 240,249,1978
subcutaneous/mouse lethal dose (50 percent kill): 4100 mg/kgNIIRDN 6,788,1982
subcutaneous/rat lethal dose (50 percent kill): 3450 mg/kgNIIRDN 6,788,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 30000 ppm/8D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationADREDL 299,449,2007

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWDERCL* 27,289,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,259,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7540; Number of Industries 35; Total Number of Facilities 7099; Number of Occupations 49; Total Number of Employees Exposed 1075065; Total Number of Female Employees Exposed 939668
National Occupational Exposure Survey 1983Hazard Code X9186; Number of Industries 3; Total Number of Facilities 798; Number of Occupations 16; Total Number of Employees Exposed 94521; Total Number of Female Employees Exposed 86562
National Occupational Hazard Survey 1974Hazard Code M0524; Number of Industries 14; Total Number of Facilities 1794; Number of Occupations 15; Total Number of Employees Exposed 65694

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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