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Poly (1 - (2 - oxo - 1 - pyrrolidinyl) ethylene) iodine complex

RTECS #: TR1579600

CAS #: 25655-41-8


UPDATE: May 2006 MW: N/R MF: (C6H9NO)nxI


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Vinyl - 2 - pyrrolidinone polymer, compd. with iodine
  2. 2 - Pyrrolidinone, 1 - ethenyl - , homopolymer, compd. with iodine
  3. Betadine
  4. Efo - dine
  5. Isodine
  1. PVP - iodine
  2. Polyvinylpyrrolidone, iodine complex
  3. Povidone - iodine
  4. Ultradine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
human
5%/48 hour CODEDG 42,90,2000
skin
rabbit
500 mg mild YACHDS 17(Suppl 1),75,1989


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human other cell types 200 ppm JTEHD6 1,977,1976
DNA repair Escherichia coli 1 L/disc JPMSAE 64,1235,1975
mutation in mammalian somatic cells mouse lymphocyte 5,000 ppm APTOD9 19,A106,1980
morphological transform mouse lymphocyte 5,000 ppm APTOD9 19,A106,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rat
lowest published toxic dose: 1,450 mg/kg (15-22 day pregnant/3 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
KSRNAM 22,4663,1988
subcutaneous
rat
lowest published toxic dose: 11,600 mg/kg (15-22 day pregnant/3 week after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
KSRNAM 22,4663,1988
subcutaneous
rat
lowest published toxic dose: 11,600 mg/kg (15-22 day pregnant/3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
KSRNAM 22,4663,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lethal dose (50 percent kill): 480 mg/kg N/R NIIRDN 6,788,1982
intravenous
rat
lethal dose (50 percent kill): 640 mg/kg N/R NIIRDN 6,788,1982
oral
mouse
lethal dose (50 percent kill): 8,100 mg/kg N/R NIIRDN 6,788,1982
oral
rat
lethal dose (50 percent kill): >8 gm/kg N/R NIIRDN 6,788,1982
subcutaneous
mouse
lethal dose (50 percent kill): 4,100 mg/kg N/R NIIRDN 6,788,1982
subcutaneous
rat
lethal dose (50 percent kill): 3,450 mg/kg N/R NIIRDN 6,788,1982
skin
guinea pig
lowest published toxic dose: 8 mg/kg Skin: After systemic exposure: Dermatitis, irritative

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
ARTODN 76,119,2002
skin
human
lowest published toxic dose: 3,400 mg/kg/24 hour Blood: Hemorrhage

Skin: After systemic exposure: Dermatitis, other
JAMAAP 240,249,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,259,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0524;
Number of Industries 14;
Total Number of Facilities 1,794;
Number of Occupations 15;
Total Number of Employees Exposed 65,694
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7540;
Number of Industries 35;
Total Number of Facilities 7,099;
Number of Occupations 49;
Total Number of Employees Exposed 1,075,065;
Total Number of Female Employees Exposed 939,668
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9186;
Number of Industries 3;
Total Number of Facilities 798;
Number of Occupations 16;
Total Number of Employees Exposed 94,521;
Total Number of Female Employees Exposed 86,562


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 9006-37-5
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