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Registry of Toxic Effects of Chemical Substances (RTECS)

Polydimethyl siloxane

RTECS #

TQ2690000

CAS #

9016-00-6

Updated

September 201

Molecular Weight

N/R

Molecular Formula

(C2H6OSi)x

Synonyms

Dimethicone 350
Dow corning 346
Good-rite
Hycar
Poly(oxy(dimethylsilylene))

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat 5 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TJADAB 31,50A,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 1500 mg/kgTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors
AMPLAO 67,589,1959

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/Dog Lethal dose: >410 mg/kgANKHEW 33,666,1988
intraperitoneal/mouse Lethal dose: >5500 mg/kgANKHEW 33,666,1988
intraperitoneal/rat Lethal dose: >2 gm/kgANKHEW 33,666,1988
intrapleural/Dog Lethal dose: >410 mg/kgANKHEW 33,666,1988
intrapleural/mouse Lethal dose: >5500 mg/kgANKHEW 33,666,1988
intrapleural/rat Lethal dose: >2 gm/kgANKHEW 33,666,1988
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTOVEFN (6),37,1996
subcutaneous/Dog Lethal dose: >410 mg/kgANKHEW 33,666,1988
subcutaneous/mouse Lethal dose: >5500 mg/kgANKHEW 33,666,1988
subcutaneous/rat Lethal dose: >2 gm/kgANKHEW 33,666,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 50 gm/kg/10D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-89051
implant/mouse lowest published toxic dose: 50 gm/kg/10D- continuousImmunological Including Allergic: Decrease in cellular immune responseNTPTR* IMM-89051
implant/mouse lowest published toxic dose: 50 gm/kg/10D- continuousLiver: Changes in liver weight

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-89051
implant/mouse lowest published toxic dose: 50 gm/kg/180D- continuousImmunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-89051
implant/mouse lowest published toxic dose: 125 gm/kg/30D- continuousLiver: Other changes

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-89051
implant/mouse lowest published toxic dose: 50 gm/kg/180D- continuousImmunological Including Allergic: Increase in cellular immune responseNTPTR* IMM-89051

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7465; Number of Industries 141; Total Number of Facilities 14142; Number of Occupations 113; Total Number of Employees Exposed 284654; Total Number of Female Employees Exposed 107989
National Occupational Hazard Survey 1974Hazard Code T1363; Number of Industries 3; Total Number of Facilities 52; Number of Occupations 4; Total Number of Employees Exposed 310

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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