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Platinum (IV) chloride

RTECS #: TP2275500

CAS #: 13454-96-1


UPDATE: February 2009 MW: 336.89 MF: Cl4Pt


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Platinum chloride (PtCl4) (6CI,7CI,8CI)
  2. Platinum chloride (PtCl4) , (SP - 4 - 1) (9CI)
  3. Platinum tetrachloride
  1. Platinum (IV) tetrachloride
  2. Tetrachloroplatinum


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
100 mg/24 hour severe AEHLAU 30,168,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition human lung 2,300 µg/L EVHPAZ 12,45,1975
DNA inhibition intraperitoneal
rat
28 µmol/kg EVHPAZ 12,57,1975
DNA repair Bacillus subtilis 1 mmol/L MUREAV 77,109,1980
mutation in microorganisms Salmonella typhimurium 100 ng/disc (+enzymatic activation step) MUREAV 77,109,1980
micronucleus test human lymphocyte 20 µmol/L MUREAV 389,183,1997
mutation in mammalian somatic cells hamster ovary 21 µmol/L MUREAV 151,293,1985
other mutation test systems Escherichia coli 100 µmol/L MUREAV 389,191,1997
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
300 µmol/L/72 hour ENMUDM 2,133,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
rat
lowest published toxic dose: 26,951 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous
mouse
lowest published toxic dose: 26,951 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): >200 mg/kg N/R ENTOX* -,448,2005
oral
rat
lethal dose (50 percent kill): 276 mg/kg N/R GTPZAB 21(7),55,1977
skin
rabbit
lowest published toxic dose: 0.4 gm/kg/24 hour Skin: After topical application: Primary irritation AEHLAU 30,168,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.002 mg(Pt)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HBTME* ,769,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.002 mg(Pt)/m3 DTLVS* 3,213,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Pt)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Pt)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Pt)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Pt)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.002 mg(Pt)/m3 (dust), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.002 mg(Pt)/m3, MAR2002
Occupational Exposure Limit - HUNGARY time-weighted average 0.002 mg(Pt)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.001 mg(Pt)/m3, sen, APR2007
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.002 mg(Pt)/m3, sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.002 mg(Pt)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg(Pt)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg(Pt)/m3 (total dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.002 mg(Pt)/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.002 mg(Pt)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.002 mg(Pt)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTME*
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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