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Registry of Toxic Effects of Chemical Substances (RTECS)

Platinum (IV) chloride

RTECS #

TP2275500

CAS #

13454-96-1

Updated

September 201

Molecular Weight

336.89

Molecular Formula

Cl4Pt

Synonyms

Platinum chloride (PtCl4) (6CI,7CI,8CI)
Platinum chloride (PtCl4), (SP-4-1) (9CI)
Platinum tetrachloride
Platinum(IV) tetrachloride
Tetrachloroplatinum

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 100 mg/24H severeAEHLAU 30,168,1975

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlung/human2300 µg/LEVHPAZ 12,45,1975
DNA inhibitionintraperitoneal/rat28 µmol/kgEVHPAZ 12,57,1975
DNA repair/Bacillus subtilis1 mmol/LMUREAV 77,109,1980
micronucleus testlymphocyte/human20 µmol/LMUREAV 389,183,1997
mutation in mammalian somatic cellsovary/hamster21 µmol/LMUREAV 151,293,1985
mutation in microorganisms/Salmonella typhimurium100 ng/disc (+enzymatic activation step)MUREAV 77,109,1980
other mutation test systems/Escherichia coli100 µmol/LMUREAV 389,191,1997
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster300 µmol/L/72HENMUDM 2,133,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 26951 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous/mouse 26951 µg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lethal dose (50 percent kill): >200 mg/kgENTOX* -,448,2005
oral/rat lethal dose (50 percent kill): 276 mg/kgGTPZAB 21(7),55,1977
skin/rabbit lowest published toxic dose: 0.04 gm/kg/24HSkin: After topical application: Primary irritationAEHLAU 30,168,1975

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.002 mg(Pt)/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHBTME* ,769,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.002 mg(Pt)/m3DTLVS* 3,213,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg(Pt)/m3 (dust), JAN1993
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Pt)/m3, MAR2002
Occupational Exposure Limit-HUNGARYtime-weighted average 0.002 mg(Pt)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.001 mg(Pt)/m3, a1 sen, s1 sen, MAY2012
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Pt)/m3, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.002 mg(Pt)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg(Pt)/m3 (total dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Pt)/m3, inhal, sen, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg(Pt)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.02 mg(Pt)/m3, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Pt)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Pt)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Pt)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Pt)/m3CFRGBR 29,1915.1000,1993

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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