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Registry of Toxic Effects of Chemical Substances (RTECS)

Pivalic acid

RTECS #

TO7700000

CAS #

75-98-9

Updated

April 2010

Molecular Weight

102.15

Molecular Formula

C5H10O2

Synonyms

2,2-Dimethylpropanoic acid
2,2-Dimethylpropionic acid
Acetic acid, trimethyl-
alpha,alpha-Dimethylpropionic acid
Kyselina 2,2-dimethylpropionova (Czech)
Kyselina pivalova (Czech)
Neopentanoic acid
Propionic acid, 2,2-dimethyl-
tert-Pentanoic acid
Trimethylacetic acid

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 188 mg/kg/47W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
CALEDQ 17,61,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 4000 mg/m3/6HBehavioral: Somnolence (general depressed activity)HPV315 -,-,2001
inhalation/rat Lowest published lethal concentration: 4000 mg/m3/6HLung, Thorax, or Respiration: DyspneaHPV315 -,-,2001
oral/rat lethal dose (50 percent kill): 900 mg/kg37ASAA 4,863,1978
oral/rat lethal dose (50 percent kill): 2000 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
HPV315 -,-,2001
skin/rabbit lethal dose (50 percent kill): 3160 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
HPV315 -,-,2001
skin/rat lethal dose (50 percent kill): 1900 mg/kg37ASAA 4,863,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
skin/rabbit lowest published toxic dose: 300 mg/kg/14D- continuousSkin: After topical application: Primary irritationHPV315 -,,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 544,179,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1178; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 1; Total Number of Employees Exposed 1462; Total Number of Female Employees Exposed 996
National Occupational Hazard Survey 1974Hazard Code A1178; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 2; Total Number of Employees Exposed 1683

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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