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Registry of Toxic Effects of Chemical Substances (RTECS)

Piperidine

RTECS #

TM3500000

CAS #

110-89-4

Updated

April 2012

Molecular Weight

85.17

Molecular Formula

C5H11N

Synonyms

Azacyclohexane
Cyclopentimine
Cypentil
Hexahydropyridine
Hexazane
Pentamethyleneimine
Pentamethylenimine
Piperidin (German)
Pyridine, hexahydro-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,837,1986
skin /rabbit 100 µg/24H open irritation testAIHAAP 23,95,1962
skin /rabbit 5 mg/24H severe85JCAE -,837,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/mouse8020 µmol/LMUREAV 203,155,1988
mutation in mammalian somatic cellslymphocyte/mouse5050 µmol/LMUTAEX 3,193,1988
mutation in mammalian somatic cellsother cell types/mouse6.06 mmol/L (-enzymatic activation step)HPV361 -,-,2003

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 3 mg/m3/24H (4D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TPKVAL 14,40,1975
inhalation/rat 100 mg/m3/24H (4D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TPKVAL 14,40,1975
inhalation/rat 100 mg/m3 (4D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TPKVAL 14,40,1975
inhalation/rat 3 mg/m3 (4D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)TPKVAL 14,40,1975
inhalation/rat 100 mg/m3 (1-22D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TPKVAL 14,40,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 6500 mg/m3TPKVAL 14,90,1975
inhalation/mouse lowest published toxic concentration: 0.4 gm/m3/2HLung, Thorax, or Respiration: Other changesTPKVAL 10,25,1968
inhalation/mouse lethal concentration (50 percent kill): 6 gm/m3TPKVAL 9,3,1967
inhalation/mouse lethal concentration (50 percent kill): 6 gm/m3Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP
TPKVAL 9,91,1967
inhalation/mouse lethal concentration (50 percent kill): 6000 mg/m3/2HTPKVAL 15,116,1979
inhalation/mouse Lowest published lethal concentration: 2 gm/m3Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 9,91,1967
inhalation/rat lethal concentration (50 percent kill): >2000 ppmHPV361 -,-,2003
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HAIHAAP 23,95,1962
inhalation/rat lowest published toxic concentration: 0.4 gm/m3/4HLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 9,91,1967
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgJEPTDQ 4(2-3),345,1980
intravenous/rabbit lowest published lethal dose: 160 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JPMRAB 7,128,1933
ocular/rabbit lowest published toxic dose: 8 pphEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 9,91,1967
oral/mammal (species unspecified) lethal dose (50 percent kill): 22400 µg/kgTPKVAL 14,90,1975
oral/mouse lethal dose (50 percent kill): 30 mg/kgTOXIA6 52,389,2008
oral/mouse lethal dose (50 percent kill): 536 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes
HPV361 -,-,2003
oral/rabbit lethal dose (50 percent kill): 145 mg/kg85GMAT -,100,1982
oral/rat lethal dose (16 percent kill): 246 mg/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Vascular: BP elevation not characterized in autonomic section

Vascular: Structural changes in vessels
TPKVAL 9,91,1967
oral/rat lethal dose (50 percent kill): 30 mg/kgTPKVAL 10,25,1968
oral/rat lethal dose (50 percent kill): 0.74 gm/kgBehavioral: Rigidity (includes catalepsy)

Gastrointestinal: Hypermotility, diarrhea

Blood: Changes in spleen
HPV361 -,-,2003
oral/rat lowest published lethal dose: 496 mg/kgTPKVAL 9,91,1967
oral/rat lethal dose (50 percent kill): 337 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from stomach
HPV361 -,-,2003
skin/rabbit lethal dose (50 percent kill): 0.32 mL/kgHPV361 -,-,2003
skin/rabbit lethal dose (50 percent kill): 276 mg/kgTOXIA6 52,389,2008
skin/rabbit lowest published toxic dose: 50 mg/kg/3HSkin: After topical application: CorrosiveTPKVAL 9,91,1967
subcutaneous/rabbit lowest published lethal dose: 300 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
JPMRAB 7,128,1933
unreported route/frog lowest published lethal dose: 1750 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Dyspnea
85IXA4 -,595,1948
unreported route/rat lethal dose (50 percent kill): 371 mg/kgTPKVAL 9,3,1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 10 mg/m3/4H/17W- intermittentVascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Other changes
TNICS* 13,95,1973
inhalation/rabbit lowest published toxic concentration: 0.002 gm/m3/14D- intermittentVascular: BP lowering not characterized in autonomic sectionTPKVAL 13,100,1973
inhalation/rabbit lowest published toxic concentration: 0.002 gm/m3/75D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 13,100,1973
inhalation/rabbit lowest published toxic concentration: 0.01 gm/m3/6W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Changes in erythrocyte (RBC) count

Blood: Other changes
TPKVAL 13,100,1973
inhalation/rabbit lowest published toxic concentration: 0.01 gm/m3/122D- intermittentVascular: Structural changes in vessels

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Urine volume decreased or anuria
TPKVAL 13,100,1973
inhalation/rabbit lowest published toxic concentration: 0.002 gm/m3/122D- intermittentKidney, Ureter, and Bladder: Other changes

Endocrine: Changes in adrenal weight

Biochemical: Metabolism (intermediary): Other proteins
TPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 10 mg/m3/14D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV361 -,,2003
inhalation/rat lowest published toxic concentration: 10 mg/m3/16W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV361 -,,2003
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/17W- intermittentVascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in leukocyte (WBC) count
TNICS* 13,95,1973
inhalation/rat lowest published toxic concentration: 0.01 gm/m3/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/75D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 0.01 gm/m3/6W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Changes in erythrocyte (RBC) count

Blood: Other changes
TPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 0.01 gm/m3/122D- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Liver function tests impaired

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/122D- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 0.002 gm/m3/6W- intermittentLung, Thorax, or Respiration: Respiratory depressionTPKVAL 13,100,1973
inhalation/rat lowest published toxic concentration: 0.01 gm/m3/75D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Changes in leukocyte (WBC) count
TPKVAL 13,100,1973
oral/rat lowest published toxic dose: 900 mg/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0533716

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (3.5 mg/m3), JUL2008
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (3.5 mg/m3), skin, JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (3.5 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84370; Number of Industries 3; Total Number of Facilities 29; Number of Occupations 20; Total Number of Employees Exposed 5797; Total Number of Female Employees Exposed 729
National Occupational Hazard Survey 1974Hazard Code 84370; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 3; Total Number of Employees Exposed 720

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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