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Registry of Toxic Effects of Chemical Substances (RTECS)

Piperazine

RTECS #

TK7800000

CAS #

110-85-0

Updated

September 201

Molecular Weight

86.16

Molecular Formula

C4H10N2

Synonyms

1,4-Diethylenediamine
Antiren
Dispermine
Hexahydro-1,4-diazine
Hexahydropyrazine
Lumbrical
Piperazidine
Piperazin (German)
Piperazine, anhydrous
Pyrazine hexahydride
Pyrazine, hexahydro-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg severeAJOPAA 29,1363,1946
eye /rabbit 250 µg/24H severe85JCAE -,862,1986
eye /rabbit 0.005 mL moderateHPV179 -,-,2003
eye /rabbit 0.02 mL severeHPV179 -,-,2003
skin /guinea pig 50%/2HTPKVAL 15,116,1979
skin /human 1%HPV179 -,-,2003
skin /rabbit 500 mg open irritation test mildUCDS** 7/16/1967
skin /rabbit 500 mg mildHPV179 -,-,2003
skin /rabbit 0.01 mL moderateHPV179 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 5400 mg/m3/2HBehavioral: Excitement

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
TPKVAL 15,116,1979
inhalation/mouse lethal concentration (50 percent kill): 5400 mg/m3/2HHPV179 -,-,2003
intramuscular/rat lethal dose (50 percent kill): >2500 mg/kgHPV179 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 125 mg/kgHPV179 -,-,2003
intravenous/mouse lethal dose (50 percent kill): 1100 mg/kgHPV179 -,-,2003
intravenous/rat lethal dose (50 percent kill): 1340 mg/kgHPV179 -,-,2003
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 15,116,1979
oral/child lowest published toxic dose: 75 mg/kgBehavioral: Sleep

Gastrointestinal: Nausea or vomiting
34ZIAG -,478,1969
oral/mouse lethal dose (50 percent kill): 600 mg/kgBCFAAI 103,414,1964
oral/mouse lowest published lethal dose: 2400 mg/kgHPV179 -,-,2003
oral/rat lethal dose (50 percent kill): 5.66 mL/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
HPV179 -,-,2003
oral/rat lethal dose (50 percent kill): 1900 mg/kgBehavioral: Excitement

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle contraction or spasticity
TPKVAL 15,116,1979
oral/rat lethal dose (50 percent kill): 1900 mg/kgHPV179 -,-,2003
skin/rabbit lethal dose (50 percent kill): 4000 mg/kgHPV179 -,-,2003
skin/rabbit lethal dose (50 percent kill): 16 mL/kgSkin: After topical application: Primary irritationHPV179 -,-,2003
skin/rabbit lowest published toxic dose: 150 mg/kgVascular: Regional or general arteriolar constriction

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,116,1979
skin/rabbit lethal dose (50 percent kill): 4 mL/kgUCDS** 7/16/1965
skin/rabbit Lethal dose: >5 mL/kgSkin: After topical application: Primary irritationHPV179 -,-,2003
subcutaneous/mouse lethal dose (50 percent kill): 1100 mg/kgHPV179 -,-,2003
subcutaneous/rat lethal dose (50 percent kill): 3700 mg/kgNIIRDN 6,635,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 21000 mg/kg/70D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 28,196,2009

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.03 ppm (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWENTOX* -,440,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.3 mg/m3, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.003 ppm (0.1 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 0.028 ppm (0.1 mg/m3), short term exposure limit 0.084 ppm (0.3 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg/m3, VLE 0.3 mg/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, sen, NOV2011
Occupational Exposure Limit-JAPANa2 sen, MAY2012
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 mg/m3; short term exposure limit 0,3 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 ppm (0.3 mg/m3);short term exposure limit 0.3 ppm (1 mg/m3), Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, sen, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84705; Number of Industries 10; Total Number of Facilities 435; Number of Occupations 25; Total Number of Employees Exposed 8786; Total Number of Female Employees Exposed 2609
National Occupational Hazard Survey 1974Hazard Code 84705; Number of Industries 4; Total Number of Facilities 132; Number of Occupations 11; Total Number of Employees Exposed 2512

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
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