Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

3-Picoline

RTECS #

TJ5000000

CAS #

108-99-6

Updated

April 2010

Molecular Weight

93.14

Molecular Formula

C6H7N

Synonyms

3-Methylpyridine
beta-Methylpyridine
beta-Picoline
m-Methylpyridine
m-Picoline
Pyridine, 3-methyl- (9CI)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H severeNTIS** OTS0534823
skin /rabbit 200 µL/24H severeNTIS** OTS0534823

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 11820 mg/m3/5HBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0534823
inhalation/rat Lowest published lethal concentration: 11820 mg/m3/5HLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV361 -,-,2003
inhalation/rat lowest published toxic concentration: 1300 ppm/4HBehavioral: Somnolence (general depressed activity)HPV361 -,-,2003
inhalation/rat Lowest published lethal concentration: 3300 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV361 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 596 mg/kgJPETAB 88,82,1946
intraperitoneal/rat lethal dose (50 percent kill): 150 mg/kgBehavioral: Somnolence (general depressed activity)FAATDF 5,920,1985
intravenous/mouse lethal dose (50 percent kill): 298 mg/kgJPETAB 88,82,1946
oral/quail lethal dose (50 percent kill): 1 gm/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 400 mg/kg85JCAE -,841,1986
oral/wild bird lethal dose (50 percent kill): 1 gm/kgAECTCV 12,355,1983
skin/guinea pig lethal dose (50 percent kill): 1 gm/kg85JCAE -,841,1986
skin/rabbit lowest published lethal dose: 200 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Pulmonary emboli

Gastrointestinal: Other changes
NTIS** OTS0534823
skin/rabbit lowest published lethal dose: 1000 mg/kgSkin: After topical application: Primary irritationHPV361 -,-,2003
skin/rabbit lowest published lethal dose: 200 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV361 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 290 ppm/2W- continuousLiver: Changes in liver weightHPV361 -,,2003
oral/rat lowest published toxic dose: 5687 mg/kg/13W- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,103,2009
oral/rat lowest published toxic dose: 2839 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changesTOXID9 -,103,2009

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2579; Number of Industries 2; Total Number of Facilities 34; Number of Occupations 2; Total Number of Employees Exposed 5202; Total Number of Female Employees Exposed 390

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
TOP