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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Picoline

RTECS #

TJ4900000

CAS #

109-06-8

Updated

April 2010

Molecular Weight

93.14

Molecular Formula

C6H7N

Synonyms

2-Methylpyridine
alpha-Methylpyridine
alpha-Picoline
Picoline
Pyridine, 2-methyl-
RCRA waste number U191

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 470 mg open irritation test mildUCDS** 2/21/1958

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae7400 ppmMUREAV 163,23,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 9 gm/m3GISAAA 57(9-10),64,1992
inhalation/rat Lowest published lethal concentration: 13200 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
HPV361 -,-,2003
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HHPV361 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 529 mg/kgTOXIA6 23,815,1985
intraperitoneal/rat lethal dose (50 percent kill): 200 mg/kgBehavioral: Somnolence (general depressed activity)FAATDF 5,920,1985
oral/guinea pig lethal dose (50 percent kill): 900 mg/kgHYSAAV 33(10-12),341,1968
oral/mouse lethal dose (50 percent kill): 674 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GISAAA 45(12),62,1980
oral/rat lethal dose (50 percent kill): 790 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GISAAA 45(12),62,1980
oral/rat lethal dose (50 percent kill): >950 mg/kgBrain and Coverings: Other degenerative changes

Gastrointestinal: Ulceration or bleeding from stomach

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV361 -,-,2003
skin/rabbit lowest published lethal dose: 0.5 gm/kgSkin: After topical application: Primary irritationHPV361 -,-,2003
skin/rabbit lowest published lethal dose: 316 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
HPV361 -,-,2003
skin/rabbit lethal dose (50 percent kill): 0.41 mL/kgHPV361 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1072 mg/kg/9W- intermittentBlood: Change in clotting factors

Blood: Thrombocytopenia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(12),18,1968
oral/rat lowest published toxic dose: 1810 µg/kg/26W- intermittentBlood: Change in clotting factors

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(12),18,1968

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3811; Number of Industries 6; Total Number of Facilities 132; Number of Occupations 8; Total Number of Employees Exposed 11240; Total Number of Female Employees Exposed 1234

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9267
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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