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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic acid, dicyclohexyl ester

RTECS #

TI0889000

CAS #

84-61-7

Updated

October 2012

Molecular Weight

330.46

Molecular Formula

C20H26O4

Synonyms

1,2-Benzenedicarboxylic acid, dicyclohexyl ester
Dicyclohexyl phthalate
Ergoplast.fdc
HF 191
KP 201
Unimoll 66

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3750 mg/kg (6-20D pregnant)Reproductive: Effects on newborn: PhysicalJAPTO* 29,510,2009
oral/rat 11250 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Physical
JAPTO* 29,510,2009
oral/rat 18500 mg/kg (6-21D preg/20D after birth)Reproductive: Maternal effects: Parturition

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOLED5 189,14,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/rat lethal dose (50 percent kill): 30 mL/kgEVHPAZ 3,61,1973

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 10500 mg/kg/7D- continuousLiver: Other changes

Liver: Changes in liver weight
APTOA6 51,217,1982
oral/rat lowest published toxic dose: 1500 mg/kg/3D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAPTO* 29,510,2009
oral/rat lowest published toxic dose: 3750 mg/kg/15D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JAPTO* 29,510,2009
oral/rat lowest published toxic dose: 7500 mg/kg/15D- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
JAPTO* 29,510,2009
oral/rat lowest published toxic dose: 11250 mg/kg/15D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JAPTO* 29,510,2009
oral/rat lowest published toxic dose: 3700 mg/kg/37D- intermittentLiver: Changes in liver weightTOLED5 189,14,2009
oral/rat lowest published toxic dose: 18500 mg/kg/37D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 189,14,2009

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXCYAC 285,83,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1160; Number of Industries 5; Total Number of Facilities 560; Number of Occupations 6; Total Number of Employees Exposed 3565; Total Number of Female Employees Exposed 967
National Occupational Hazard Survey 1974Hazard Code M1160; Number of Industries 26; Total Number of Facilities 1479; Number of Occupations 27; Total Number of Employees Exposed 13714

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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