CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Phthalonitrile

RTECS #: TI8575000

CAS #: 91-15-6


UPDATE: September 1999 MW: 128.14 MF: C8H4N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzendikarbonitril (Czech)
  2. 1,2 - Benzenedicarbonitrile
  3. 1,2 - Dicyanobenzene
  4. Ftalodinitril (Czech)
  5. Ftalonitril (Czech)
  6. Phthalic acid dinitrile
  1. Phthalodinitrile
  2. USAF ND - 09
  3. o - Dicyanobenzene
  4. o - Pdn
  5. o - Phthalodinitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 21 gm/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia
VOONAW 18(1),81,1972
oral
rat
lowest published toxic dose: 7,425 mg/kg/66 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia
VOONAW 18(1),81,1972
subcutaneous
mouse
lowest published toxic dose: 7 gm/kg/63 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Tumorigenic: Tumors at site of application
VOONAW 18(1),81,1972
subcutaneous
rat
lowest published toxic dose: 473 mg/kg/21 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia
VOONAW 18(1),81,1972
skin
mouse
lowest published toxic dose: 813 mg/kg/46 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Ovarian tumors
VOONAW 18(1),81,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat
lethal dose (50 percent kill): 62 mg/kg N/R KJMDA6 11,63,1965
oral
cat
lowest published lethal dose: 20 mg/kg Behavioral: Convulsions or effect on seizure threshold ZAARAM 19,225,1969
oral
mouse
lethal dose (50 percent kill): 65 mg/kg Behavioral: Convulsions or effect on seizure threshold INHEAO 4,11,1966
oral
rat
lethal dose (50 percent kill): 30 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0540933
oral
rabbit
lowest published lethal dose: 25 mg/kg Behavioral: Convulsions or effect on seizure threshold ZAARAM 19,225,1969
subcutaneous
mouse
lethal dose (50 percent kill): 46 mg/kg Behavioral: Convulsions or effect on seizure threshold INHEAO 4,11,1966
skin
guinea pig
lethal dose (50 percent kill): >1 gm/kg N/R NTIS** OTS0540933


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
KJMDA6 Kobe Journal of the Medical Sciences. (Kobe Univ. School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650, Japan) V.1- 1951-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us