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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalonitrile

RTECS #

TI8575000

CAS #

91-15-6

Updated

September 201

Molecular Weight

128.14

Molecular Formula

C8H4N2

Synonyms

1,2-Benzendikarbonitril (Czech)
1,2-Benzenedicarbonitrile
1,2-Dicyanobenzene
Ftalodinitril (Czech)
Ftalonitril (Czech)
o-Dicyanobenzene
o-Pdn
o-Phthalodinitrile
Phthalic acid dinitrile
Phthalodinitrile
USAF ND-09

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 21 gm/kg/65W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia
VOONAW 18(1),81,1972
oral/rat lowest published toxic dose: 7425 mg/kg/66W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia
VOONAW 18(1),81,1972
skin/mouse lowest published toxic dose: 813 mg/kg/46W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Ovarian tumors
VOONAW 18(1),81,1972
subcutaneous/mouse lowest published toxic dose: 7 gm/kg/63W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Tumorigenic: Tumors at site of application
VOONAW 18(1),81,1972
subcutaneous/rat lowest published toxic dose: 473 mg/kg/21W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Leukemia
VOONAW 18(1),81,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgNTIS** AD277-689
intraperitoneal/rat lethal dose (50 percent kill): 62 mg/kgKJMDA6 11,63,1965
oral/cat lowest published lethal dose: 20 mg/kgBehavioral: Convulsions or effect on seizure thresholdZAARAM 19,225,1969
oral/mouse lethal dose (50 percent kill): 65 mg/kgBehavioral: Convulsions or effect on seizure thresholdINHEAO 4,11,1966
oral/rabbit lowest published lethal dose: 25 mg/kgBehavioral: Convulsions or effect on seizure thresholdZAARAM 19,225,1969
oral/rat lethal dose (50 percent kill): 30 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NTIS** OTS0540933
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgNTIS** OTS0540933
subcutaneous/mouse lethal dose (50 percent kill): 46 mg/kgBehavioral: Convulsions or effect on seizure thresholdINHEAO 4,11,1966

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.01 ppm, skin, MAY2012

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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