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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalimide, N-((trichloromethyl)thio)-

RTECS #

TI5685000

CAS #

133-07-3; 52306-33-9

Updated

March 2011

Molecular Weight

296.55

Molecular Formula

C9H4Cl3NO2S

Synonyms

1H-Isoindole-1,3(2H)-dione, 2-((trichloromethyl)thio)-
2-((Trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione
Acryptan
Cymoxanil
ENT 26539
Faltex
Folnit
Folpan
Folpel
Folpet
Folpex
Ftalan
Fungitrol II
Intercide TMP
N-(Trichlor-methylthio)-phthalamid (German)
N-(Trichlormethylthio)phthalimide
N-(Trichloromethylmercpato)phthalimide
N-(Trichloromethylthio)phthalimide
Orthophaltan
Phaltan
Phthaltan
SHA 081601
Spolacid
Thiophal
Trichlormethylthioimid kyseliny ftalove (Czech)
Troysan anti-mildew O
Vinicoll

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 0.1%/48HCODEDG 17,212,1987

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human15 µg/L/15MMUREAV 53,263,1978
DNA DamageHeLa cell/human1300 nmol/LEMMUEG 17,20,1991
DNA inhibitionother cell types/rat8 mg/LARTODN 45,101,1980
DNA inhibitionlymphocyte/human5 mg/LARTODN 45,101,1980
DNA inhibitionHeLa cell/human1300 nmol/LEMMUEG 17,20,1991
DNA repair/Bacillus subtilis10 µg/discMUREAV 40,19,1976
DNA repair/Escherichia coli4 µg/wellMUREAV 133,161,1984
Dominant Lethal Testoral/rat500 mg/kg/5DFCTXAV 10,363,1972
gene conversion and mitotic recombination/Saccharomyes cerevisiae200 ppmMUREAV 10,533,1970
mutation in mammalian somatic cellslymphocyte/mouse270 µg/LNTIS** PB84-138973
mutation in mammalian somatic cellsovary/hamster250 µg/LENMUDM 3,233,1981
mutation in mammalian somatic cellsovary/hamster0.75 mg/L/10H (-enzymatic activation step)FEREAC 68,10377,2003
mutation in mammalian somatic cellsovary/hamster0.26 mg/L/10H (+enzymatic activation step)FEREAC 68,10377,2003
mutation in mammalian somatic cellsovary/hamster25 mg/L/20H (+enzymatic activation step)FEREAC 68,10377,2003
mutation in microorganisms/Bacillus subtilis50 µg/plate (+/-enzymatic activation step)JAFCAU 29,268,1981
mutation in microorganisms/Salmonella typhimurium16 nmol/plate (+enzymatic activation step)CRNGDP 2,283,1981
mutation in microorganisms/Salmonella typhimurium1 µg/plate (-enzymatic activation step)NTIS** PB268-647
mutation in microorganisms/Escherichia coli5 µg/plate (+/-enzymatic activation step)NTIS** PB268-647
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster2000 ppmJPFCD2 15,867,1980
Unscheduled DNA Synthesisfibroblast/human100 µmol/LNTIS** PB268-647

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mouse 491 mg/m3/4H (6-13D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** PB84-128099
intraperitoneal/rat 500 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972
oral/rat 500 mg/kg (5D male)Reproductive: Effects on embryo or fetus: Fetal deathFCTXAV 10,363,1972
oral/rabbit 488 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXAPA9 13,420,1968
oral/hamster 500 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTXAPA9 16,24,1970
oral/hamster 900 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTXAPA9 16,24,1970
oral/hamster 600 mg/kg (7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXAPA9 16,24,1970
subcutaneous/mouse 900 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB223-160
subcutaneous/mouse 900 mg/kg (6-14D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** PB223-160

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 437 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
JJCREP 81,514,1990
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): >6 gm/m3/2HTXAPA9 45,320,1978
inhalation/rat lethal concentration (50 percent kill): >5 gm/m3/2HTXAPA9 45,320,1978
inhalation/rat lethal concentration (50 percent kill): >0.48 gm/m3/4HFEREAC 68,1182,2003
intraperitoneal/mouse lethal dose (50 percent kill): 80 mg/kgBehavioral: Convulsions or effect on seizure thresholdABMGAJ 7,502,1961
intraperitoneal/rat lethal dose (50 percent kill): 40 mg/kgENTOX* -,349,2005
intratracheal/rat lowest published toxic dose: 2 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCLPH* 23(Suppl 1),6,2009
oral/mouse lethal dose (50 percent kill): 1546 mg/kgGTPZAB 18(5),50,1974
oral/rabbit lethal dose (50 percent kill): 1115 mg/kgGTPZAB 18(5),50,1974
oral/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 68,1182,2003
oral/rat lethal dose (50 percent kill): 2636 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
NTIS** OTS0533649-9
oral/wild bird lethal dose (50 percent kill): >2.51 mg/kgENTOX* -,349,2005
skin/mouse lowest published lethal dose: 5 gm/kgJACTDZ 9,642,1991
skin/rabbit lethal dose (50 percent kill): >22.6 gm/kgENTOX* -,349,2005
skin/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 68,1182,2003
unreported route/mouse lethal dose (50 percent kill): 750 mg/kgABMGAJ 1,450,1958
unreported route/rat lethal dose (50 percent kill): >10 gm/kgRREVAH 36,240,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 397082 mg/kg/113W- continuousGastrointestinal: TumorsHBPTO* 1,814,2001
oral/mouse lowest published toxic dose: 109.5 gm/kg/2Y- continuousGastrointestinal: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously
FEREAC 68,10377,2003
oral/rat lowest published toxic dose: 25550 mg/kg/2Y- continuousGastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes
FEREAC 68,1182,2003
oral/rat lowest published toxic dose: 45000 mg/kg/90D- continuousBrain and Coverings: Changes in brain weight

Biochemical: Metabolism (intermediary): Other proteins
FEREAC 68,1182,2003
skin/rat lowest published toxic dose: 21 mg/kg/6H/30D- continuousSkin: After topical application: Primary irritationFEREAC 68,1182,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 32,3,1975
TOXICOLOGY REVIEWMUREAV 557,109,2004
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 613,17,2006
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,349,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 72,41913,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,121,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0327; Number of Industries 8; Total Number of Facilities 628; Number of Occupations 21; Total Number of Employees Exposed 10509; Total Number of Female Employees Exposed 1422
National Occupational Hazard Survey 1974Hazard Code M0327; Number of Industries 4; Total Number of Facilities 608; Number of Occupations 8; Total Number of Employees Exposed 1240

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
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