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Phthalic acid, bis (2 - ethylhexyl) ester

RTECS #: TI0350000

CAS #: 117-81-7


UPDATE: May 2009 MW: 390.62 MF: C24H38O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenedicarboxylic acid, bis (2 - ethylhexyl) ester
  2. 2 - Ethylhexyl phthalate
  3. Bis (2 - ethylhexyl) - 1,2 - benzenedicarboxylate
  4. Bis (2 - ethylhexyl) phthalate
  5. Bis - (2 - ethylhexyl) ester kyseliny ftalove (Czech)
  6. Bisoflex 81
  7. Bisoflex DOP
  8. Compound 889
  9. DEHP
  10. Di (2 - ethylhexyl) orthophthalate
  11. Di (2 - ethylhexyl) phthalate
  12. Di - (2 - ehylhexyl) phthalate
  13. Di - (2 - ethylhexyl) phthalate
  14. Di - 2 - ethylhexyl phthalate
  15. Di - sec - octyl phthalate (ACGIH:OSHA)
  16. Diethylhexyl phthalate
  17. Dioctyl phthalate
  18. Ergoplast FDO
  19. Ethylhexyl phthalate
  20. Eviplast 80
  21. Eviplast 81
  22. Fleximel
  23. Flexol DOP
  24. Flexol Plasticizer DOP
  1. Good - rite GP 264
  2. Hatcol DOP
  3. Hercoflex 260
  4. Jayflex DOP
  5. Kodaflex DOP
  6. Mollan O
  7. NCI - C52733
  8. Nuoplaz DOP
  9. Octoil
  10. Palatinol AH
  11. Phthalic acid dioctyl ester
  12. Pittsburgh PX - 138
  13. Platinol AH
  14. Platinol DOP
  15. RC Plasticizer DOP
  16. RCRA waste number U028
  17. Reomol D 79P
  18. Reomol DOP
  19. Sicol 150
  20. Staflex DOP
  21. Truflex DOP
  22. Vestinol AH
  23. Vinicizer 80
  24. Witcizer 312


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg mild AJOPAA 29,1363,1946
eye
rabbit
500 mg/24 hour mild 85JCAE -,389,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,389,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
hamster
7,500 mg/kg EVHPAZ 45,119,1982
cytogenetic analysis human leukocyte 6 mg/L JPMSAE 65,1648,1976
dominant lethal test intraperitoneal
mouse
12,780 mg/kg TXAPA9 29,35,1974
dominant lethal test subcutaneous
mouse
2,970 mg/kg/10 day- intermittent JTEHD6 16,71,1985
DNA damage oral
rat
14 gm/kg/14 day- intermittent FCTOD7 42,107,2004
unscheduled DNA synthesis oral
mouse
202 gm/kg/40 week- continuous TXAPA9 96,494,1988
unscheduled DNA synthesis rat liver 500 mol/L PMRSDJ 5,371,1985
unscheduled DNA synthesis oral
rat
670 mg/kg PAACA3 27,148,1986
mutation in microorganisms mouse lymphocyte 40 mg/L (+enzymatic activation step) PMRSDJ 5,569,1985
mutation in microorganisms Salmonella typhimurium 5 mg/plate (-enzymatic activation step) EVHPAZ 45,119,1982
mutation in microorganisms Saccharomyes cerevisiae 1,541 mg/L (+/-enzymatic activation step) PMRSDJ 5,271,1985
mutation in microorganisms Saccharomyes cerevisiae 4,905 mg/L/16 hour MUTAEX 20,105,2004
gene conversion and mitotic recombination Saccharomyes cerevisiae 5 gm/L PMRSDJ 5,217,1985
morphological transform oral
hamster
750 mg/kg EVHPAZ 45,119,1982
morphological transform hamster embryo 4 mg/L PMRSDJ 5,665,1985
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 35,300,2000
other mutation test systems oral
mouse
1 gm/kg MUREAV 343,157,1995
phage inhibition capacity Escherichia coli 50 g/well MUREAV 260,349,1991
sister chromatid exchange hamster ovary 25 mg/L SCIEAS 236,933,1987
sister chromatid exchange human lymphocyte 50 mol/L MUREAV 211,77,1989
sex chromosome loss and nondisjunction hamster liver 50 mg/L PMRSDJ 5,397,1985
specific locus test oral
Drosophila melanogaster
200 mmol/L/48 hour MUREAV 222,359,1989
sperm morphology oral
rat
1 pph/60 day- continuous EVHPAZ 65,343,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 30 gm/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
EVHPAZ 65,255,1986
intraperitoneal
mouse
lowest published toxic dose: 25,560 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EVHPAZ 3,81,1973
intraperitoneal
mouse
lowest published toxic dose: 12,780 mg/kg (1 day male) Reproductive: Effects on embryo or fetus: Fetal death EVHPAZ 3,81,1973
intraperitoneal
mouse
lowest published toxic dose: 12,780 g/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 29,35,1974
intraperitoneal
mouse
lowest published toxic dose: 24 gm/kg (7-9 day pregnant) Reproductive: Effects on fertility: Abortion ARTODN 56,263,1985
intraperitoneal
rat
lowest published toxic dose: 6 gm/kg (3-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JDSCAE 55,696,1972
intraperitoneal
rat
lowest published toxic dose: 10 gm/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Other developmental abnormalities
JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 5 gm/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 1 gm/kg (10 day male) Reproductive: Other effects on male TXAPA9 62,121,1982
intraperitoneal
rat
lowest published toxic dose: 6 gm/kg (3-9 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 6 mL/kg (3-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 2 mL/kg (3 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 2 mL/kg (6 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 4 mL/kg (3-6 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) EVHPAZ 3,91,1973
intravenous
mouse
lowest published toxic dose: 50 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) NTIS** PB250-102
intravenous
mouse
lowest published toxic dose: 350 mg/kg (7 day male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** PB250-102
intravenous
mouse
lowest published toxic dose: 15 mg/kg (3-5 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB250-102
intravenous
mouse
lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Other measures of fertility NTIS** PB250-102
oral
guinea pig
lowest published toxic dose: 20 gm/kg (10 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 45,77,1982
oral
mammal (species unspecified)
lowest published toxic dose: 20 gm/kg (10 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 45,77,1982
oral
mammal (species unspecified)
lowest published toxic dose: 509 gm/kg (60 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 6,341,1976
oral
mouse
lowest published toxic dose: 78,880 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
mouse
lowest published toxic dose: 4,200 mg/kg (21 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) OKEHDW 15,129,1977
oral
mouse
lowest published toxic dose: 1 gm/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 45,71,1982
oral
mouse
lowest published toxic dose: 2,040 mg/kg (1-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB85-105674
oral
mouse
lowest published toxic dose: 2,040 mg/kg (1-17 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TJADAB 27,84A,1983
oral
mouse
lowest published toxic dose: 8,400 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ENVRAL 22,245,1980
oral
mouse
lowest published toxic dose: 49.2 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOLED5 4,113,1979
oral
mouse
lowest published toxic dose: 98.4 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TOLED5 4,113,1979
oral
mouse
lowest published toxic dose: 984.6 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TOLED5 4,113,1979
oral
mouse
lowest published toxic dose: 1.6 gm/kg (17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
NTIS** #PB88204300
oral
mouse
lowest published toxic dose: 1.6 gm/kg (17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB88204300
oral
mouse
lowest published toxic dose: 2.04 gm/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus
NTIS** #PB85-105674
oral
mouse
lowest published toxic dose: 2.04 gm/kg (1-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
NTIS** #PB85-105674
oral
mouse
lowest published toxic dose: 1.6 gm/kg (33 day male/33 day prior to copulation/22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FCTOD7 40,1499,2002
oral
mouse
lowest published toxic dose: 15 gm/kg (33 day male/33 day prior to copulation-4 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Behavioral
FCTOD7 40,1499,2002
oral
mouse
lowest published toxic dose: 27 gm/kg (33 day male/33 day prior to copulation-4 week after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) FCTOD7 40,1499,2002
oral
mouse
lowest published toxic dose: 0.6 mg/kg (multigeneration) Reproductive: Effects on newborn: Delayed effects FCTOD7 40,1499,2002
oral
mouse
lowest published toxic dose: 1,692 mg/kg (4 week prior to copulation/1-19 day pregnant) Reproductive: Effects on newborn: Sex ratio FCTOD7 41,1429,2003
oral
mouse
lowest published toxic dose: 1,008 mg/kg (4 week male) Reproductive: Effects on newborn: Sex ratio FCTOD7 41,1429,2003
oral
mouse
lowest published toxic dose: 2.7 gm/kg (4 week male/ 4 week prior to copulation-19 day pregnant) Reproductive: Effects on newborn: Sex ratio FCTOD7 41,1429,2003
oral
mouse
lowest published toxic dose: 109.2 gm/kg (13 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOXID9 78,353,2004
oral
rat
lowest published toxic dose: 7,140 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 26,253,1973
oral
rat
lowest published toxic dose: 35 mg/kg (14 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes FCTXAV 15,389,1977
oral
rat
lowest published toxic dose: 6 gm/kg (3 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 59,290,1986
oral
rat
lowest published toxic dose: 17,200 mg/kg (multigenerations) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NEZAAQ 31,507,1976
oral
rat
lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Hepatobiliary system
IJEBA6 27,885,1989
oral
rat
lowest published toxic dose: 9,766 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 35,41,1987
oral
rat
lowest published toxic dose: 137 mL/kg (1-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Physical FCTOD7 36,963,1998
oral
rat
lowest published toxic dose: 72,000 mg/kg (60 day male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) EVHPAZ 65,343,1986
oral
rat
lowest published toxic dose: 10 gm/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB85-105658
oral
rat
lowest published toxic dose: 11.46 gm/kg (20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #87119046
oral
rat
lowest published toxic dose: 20 gm/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NTIS** #PB85-105658
oral
rat
lowest published toxic dose: 6,260 mg/kg (20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
NTIS** #87119046
oral
rat
lowest published toxic dose: 9.6 gm/kg (8 day pregnant-17 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72,283,2003
oral
rat
lowest published toxic dose: 3.2 gm/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72,283,2003
oral
rat
lowest published toxic dose: 352 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Endocrine system
TOXID9 72,283,2003
oral
rat
lowest published toxic dose: 1 gm/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system BIREBV 65,1252,2001
oral
rat
lowest published toxic dose: 30.8 gm/kg (3-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
EVHPAZ 109,229,2001
oral
rat
lowest published toxic dose: 61.5 gm/kg (3-22 day pregnant/21 day after birth) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Germ cell effects (in offspring)
EVHPAZ 109,229,2001
oral
rat
lowest published toxic dose: 123 gm/kg (3-22 day pregnant/21 day after birth) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
EVHPAZ 109,229,2001
oral
rat
lowest published toxic dose: 4,500 mg/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system REPTED 17,475,2003
oral
rat
lowest published toxic dose: 5,000 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),272,2003
oral
rat
lowest published toxic dose: 4,500 mg/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 18,53,2004
oral
rat
lowest published toxic dose: 11.3 gm/kg (7-21 day pregnant) Reproductive: Other developmental abnormalities REPTED 18,53,2004
oral
rat
lowest published toxic dose: 418 mg/kg (4 week male/4 week prior to copulation/0-3 week pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TXAPA9 197,231,2004
oral
rat
lowest published toxic dose: 2 gm/kg (4 week male/4 week prior to copulation/0-3 week pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 197,231,2004
oral
rat
lowest published toxic dose: 2,090 mg/kg (multigeneration) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TXAPA9 197,231,2004
oral
rat
lowest published toxic dose: 3,300 mg/kg (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 44,355,2005
oral
rat
lowest published toxic dose: 6,750 mg/kg (8-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,355,2005
oral
rat
lowest published toxic dose: 500 mg/kg (14-18 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 78,282,2004
oral
rat
lowest published toxic dose: 28.5 mg/kg (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
TOXID9 90,74,2006
oral
rat
lowest published toxic dose: 2,500 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOXID9 90,316,2006
oral
rat
lowest published toxic dose: 570 mg/kg (6 day pregnant-21 day after birth) Reproductive: Effects on newborn: Germ cell effects (in offspring) TOXID9 228,85,2006
oral
rat
lowest published toxic dose: 190 mg/kg (6 day pregnant-21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 228,85,2006
oral
rat
lowest published toxic dose: 1.71 mg/kg (6 day pregnant-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 228,85,2006
oral
rat
lowest published toxic dose: 15,390 mg/kg (6 day pregnant-21 day after birth) Reproductive: Effects on newborn: Delayed effects TOXID9 229,114,2007
oral
rat
lowest published toxic dose: 1,500 mg/kg (7-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 223,144,2006
oral
rat
lowest published toxic dose: 2,295 mg/kg (6 day pregnant-1 day after birth) Reproductive: Effects on newborn: Other neonatal measures or effects TXCYAC 225,64,2006
oral
rat
lowest published toxic dose: 2.3 mg/kg (6 day pregnant-1 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXCYAC 225,64,2006
oral
rat
lowest published toxic dose: 11,745 mg/kg (6 day pregnant-13 day after birth) Reproductive: Effects on newborn: Physical TXCYAC 225,64,2006
oral
rat
lowest published toxic dose: 190 mg/kg (6 day pregnant-21 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TXCYAC 225,64,2006
oral
rat
lowest published toxic dose: 8,000 mg/kg (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTSCDR 30,175,2005
oral
rat
lowest published toxic dose: 3,000 mg/kg (7-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTSCDR 30,175,2005
oral
rat
lowest published toxic dose: 12,000 mg/kg (7-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Other postnatal measures or effects
JTSCDR 30,175,2005
oral
rat
lowest published toxic dose: 5,000 mg/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTSCDR 30,175,2005
oral
rat
lowest published toxic dose: 30,000 mg/kg (0-19 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Central nervous system
ARTODN 81,57,2007
oral
rat
lowest published toxic dose: 570 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Physical TOSCF2 91,247,2006
oral
rat
lowest published toxic dose: 0.765 mg/kg (6-22 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects TOSCF2 91,247,2006
oral
rat
lowest published toxic dose: 2,295 mg/kg (6-22 day pregnant) Reproductive: Effects on newborn: Physical TOSCF2 91,247,2006
oral
rat
lowest published toxic dose: 46.17 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOSCF2 91,247,2006
oral
rat
lowest published toxic dose: 21.5 gm/kg (1-22 day pregnant/21 day after birth) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
HETOEA 25,297,2006
oral
rat
lowest published toxic dose: 21.5 gm/kg (1-22 day pregnant/21 day after birth) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Behavioral
HETOEA 25,297,2006
oral
rat
lowest published toxic dose: 4,300 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) HETOEA 25,297,2006
oral
rat
lowest published toxic dose: 585 mg/kg (6-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Physical NSAPCC 372(Suppl 1),100,2006
oral
rat
lowest published toxic dose: 5,265 mg/kg (6-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects
NSAPCC 372(Suppl 1),100,2006
oral
rat
lowest published toxic dose: 15,390 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Other postnatal measures or effects
NSAPCC 372(Suppl 1),100,2006
oral
rat
lowest published toxic dose: 2,430 mg/kg (6-22 day pregnant/1 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects NSAPCC 372(Suppl 1),100,2006
oral
rat
lowest published toxic dose: 190 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system NSAPCC 372(Suppl 1),100,2006
oral
rat
lowest published toxic dose: 570 mg/kg (6-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical
NSAPCC 372(Suppl 1),100,2006
oral
rat
lowest published toxic dose: 3,750 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Physical
TOLED5 170,177,2007
oral
rat
lowest published toxic dose: 3,750 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOLED5 170,177,2007
oral
rat
lowest published toxic dose: 4,800 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Physical TERP2* -,367,2005
subcutaneous
mouse
lowest published toxic dose: 2,970 mg/kg (3 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 16,71,1985
subcutaneous
mouse
lowest published toxic dose: 19,722 mg/kg (3 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
JTEHD6 26,39,1989
subcutaneous
mouse
lowest published toxic dose: 1,972 mg/kg (3 day male) Reproductive: Other effects on male JTEHD6 26,39,1989
subcutaneous
mouse
lowest published toxic dose: 9,861 mg/kg (3 day prior to copulation) Reproductive: Other effects on female JTEHD6 26,39,1989
unreported route
rat
lowest published toxic dose: 41,250 mg/kg (14 day pregnant-3 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,225,2001
unreported route
rat
lowest published toxic dose: 2,500 mg/kg (14-18 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 -,10,2008


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 260 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-217,1982
oral
mouse
toxic dose : 519 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-217,1982
oral
mouse
toxic dose : 120 gm/kg/24 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CRNGDP 4,1021,1983
oral
mouse
toxic dose : 262 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 65,271,1986
oral
mouse
lowest published toxic dose: 98.5 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 519,120 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-184011
oral
mouse
lowest published toxic dose: 259,560 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-184011
oral
mouse
lowest published toxic dose: 32,760 mg/kg/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
JTPAE7 29,458,2001
oral
rat
lowest published toxic dose: 216 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Tumors
NTPTR* NTP-TR-217,1982
oral
rat
toxic dose : 433 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
NTPTR* NTP-TR-217,1982
oral
rat
toxic dose : 524 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 65,271,1986
oral
rat
toxic dose : 438 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CALEDQ 38,15,1987
oral
rat
toxic dose : 91 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
TOSCF2 50,195,1999
oral
rat
lowest published toxic dose: 430.8 gm/kg/78 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 519,120 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-184011
oral
rat
lowest published toxic dose: 432,600 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB82-184011


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 300 mg/m3/50 minute Lung, Thorax, or Respiration: Respiratory depression TXCYAC 235,119,2007
inhalation
rat
lowest published toxic concentration: 100 mg/m3 Behavioral: Alteration of classical conditioning TPKVAL 15,123,1979
inhalation
rat
lowest published toxic concentration: 10 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,123,1979
intraperitoneal
mouse
lethal dose (50 percent kill): 14 gm/kg Vascular: BP lowering not characterized in autonomic section

Behavioral: Excitement
JPMSAE 55,158,1966
intraperitoneal
rat
lethal dose (50 percent kill): 30,700 mg/kg N/R JIHTAB 27,130,1945
intraperitoneal
rat
lowest published toxic dose: 2 mL/kg Reproductive: Maternal effects: Parturition EVHPAZ 3,91,1973
intraperitoneal
rabbit
lethal dose : >31 mL/kg N/R AMIHAB 13,259,1956
intratracheal
rat
lowest published lethal dose: 30 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Hemorrhage
TPKVAL 2,59,1961
intravenous
mouse
lethal dose (50 percent kill): 1,060 mg/kg N/R NTIS** PB250-102
intravenous
rat
lethal dose (50 percent kill): 250 mg/kg Lung, Thorax, or Respiration: Other changes TXAPA9 45,230,1978
oral
guinea pig
lethal dose (50 percent kill): 26 gm/kg N/R IMEMDT 29,269,1982
oral
man
lowest published toxic dose: 143 mg/kg Gastrointestinal: Other changes JIHTAB 27,130,1945
oral
monkey
lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 72(Suppl 1),384,2003
oral
mouse
lowest published toxic dose: 984.6 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 4,113,1979
oral
mouse
lethal dose (50 percent kill): 29.5 gm/kg N/R TOLED5 4,113,1979
oral
mouse
lowest published toxic dose: 40 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 194,35,2003
oral
mouse
lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Necrotic changes
TPKVAL 2,59,1961
oral
rat
lethal dose (50 percent kill): 30 gm/kg N/R NPIRI* 2,32,1975
oral
rat
lowest published toxic dose: 2,000 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Metabolism (intermediary): Other
TXAPA9 200,103,2004
oral
rat
lowest published toxic dose: 2,000 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Other
TOXID9 1,72,2001
oral
rat
lowest published toxic dose: 2,000 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOLED5 173,107,2007
oral
rabbit
lethal dose (50 percent kill): 34 gm/kg N/R EVHPAZ 4,3,1973
skin
guinea pig
lethal dose (50 percent kill): 10 gm/kg N/R EVHPAZ 4,3,1973
skin
mouse
lowest published lethal dose: 4 gm/kg Skin and Appendages: Other glands GISAAA 45(6),35,1980
skin
mouse
lowest published toxic dose: 220 gm/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JOETD7 115,25,2008
skin
rat
lowest published lethal dose: 4 gm/kg Skin and Appendages: Other glands GISAAA 45(6),35,1980
skin
rabbit
lethal dose (50 percent kill): 25 gm/kg N/R JIHTAB 27,130,1945
unreported route
guinea pig
lethal dose (50 percent kill): 40,500 mg/kg N/R GTPZAB 32(7),52,1988
unreported route
mouse
lethal dose (50 percent kill): 7 gm/kg N/R GTPZAB 32(7),52,1988
unreported route
rat
lethal dose (50 percent kill): 47 gm/kg N/R GTPZAB 32(7),52,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 13 mg/m3/14 week- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 235,119,2007
inhalation
rat
lowest published toxic concentration: 940 mg/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FCTOD7 30,915,1992
inhalation
rat
lowest published toxic concentration: 25 mg/m3/63 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 90,24,2006
inhalation
rat
lowest published toxic concentration: 25 mg/m3/6 hour/24 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 93,164,2006
inhalation
rat
lowest published toxic concentration: 5 mg/m3/6 hour/8 day- intermittent Reproductive: Other effects on female TOSCF2 93,164,2006
inhalation
rat
lowest published toxic concentration: 25 mg/m3/6 hour/63 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 93,164,2006
inhalation
rat
lowest published toxic concentration: 25 mg/m3/6 hour/20 day- intermittent Endocrine: Change in LH

Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 93,164,2006
inhalation
rat
lowest published toxic concentration: 5 mg/m3/6 hour/20 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOSCF2 93,164,2006
intramuscular
rat
lowest published toxic dose: 8,400 mg/kg/1 week- continuous Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Metabolism (intermediary): Lipids including transport

Related to Chronic Data: Changes in testicular weight
TOLED5 23,67,1984
intraperitoneal
mouse
lowest published toxic dose: 10,500 mg/kg/6 week- intermittent Gastrointestinal: Peritonitis

Related to Chronic Data: Changes in testicular weight
JPMSAE 55,158,1966
intraperitoneal
mouse
lowest published toxic dose: 11,111.2 g/kg/8 day- intermittent Immunological Including Allergic: Increase in humoral response TOLED5 170,223,2007
intraperitoneal
rat
lowest published toxic dose: 9 mg/kg/11 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
IJEBA6 36,264,1998
intraperitoneal
rat
lowest published toxic dose: 15 mL/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ENVRAL 12,131,1976
intraperitoneal
rat
lowest published toxic dose: 15 mL/kg/10 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ENVRAL 12,131,1976
intraperitoneal
rat
lowest published toxic dose: 6 mL/kg/7 day- intermittent Reproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 4 mg/kg/3 day- intermittent Reproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 6.25 gm/kg/5 day- intermittent Endocrine: Androgenic BECTA6 21,65,1979
intravenous
rat
lowest published toxic dose: 3,000 mg/kg/11 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
EVHPAZ 65,237,1986
intravenous
rat
lowest published toxic dose: 6,300 mg/kg/21 day- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
IJTOFN 22,159,2003
intravenous
rat
lowest published toxic dose: 12,600 mg/kg/21 day- intermittent Blood: Changes in spleen

Skin: After systemic exposure: Dermatitis, irritative

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 22,159,2003
oral
domestic bird
lowest published toxic dose: 384 mg/kg/30 day- continuous Nutritional and Gross Metabolic: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
BECTA6 25,345,1980
oral
guinea pig
lowest published toxic dose: 30 gm/kg/15 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 40,209,1988
oral
hamster
lowest published toxic dose: 14 gm/kg/14 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 72,46,1984
oral
mammal (species unspecified)
lowest published toxic dose: 509 gm/kg/60 week- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 6,341,1976
oral
monkey
lowest published toxic dose: 227,500 mg/kg/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain ENVRAL 78,43,1998
oral
monkey
lowest published toxic dose: 42 gm/kg/60 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 72,384,2003
oral
monkey
lowest published toxic dose: 221.7 gm/kg/454 day- intermittent Liver: Other changes TXAPA9 197,229,2004
oral
monkey
lowest published toxic dose: 227,500 mg/kg/65 week- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
JTEHF8 69,1651,2006
oral
monkey
lowest published toxic dose: 227,500 mg/kg/65 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTEHF8 69,1651,2006
oral
monkey
lowest published toxic dose: 28,000 mg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
JTPAE7 21,73,2008
oral
mouse
lowest published toxic dose: 30 gm/kg/15 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOLED5 40,209,1988
oral
mouse
lowest published toxic dose: 33,852 mg/kg/13 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-217,1982
oral
mouse
lowest published toxic dose: 403 gm/kg/40 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TXAPA9 96,494,1988
oral
mouse
lowest published toxic dose: 213 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0559217
oral
mouse
lowest published toxic dose: 6,720 mg/kg/14 day- continuous Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
BCPCA6 62,249,2001
oral
mouse
lowest published toxic dose: 921.7 gm/kg/104 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 1,061.6 gm/kg/104 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Liver: Changes in liver weight

Related to Chronic Data: Changes in uterine weight
TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 212.7 gm/kg/104 week- continuous Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Changes in testicular weight
TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 691.3 gm/kg/78 week- continuous Liver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 796.2 gm/kg/78 week- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 193.4 gm/kg/78 week- continuous Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli TOSCF2 58,377,2000
oral
mouse
lowest published toxic dose: 60,480 mg/kg/12 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTPAE7 29,458,2001
oral
mouse
lowest published toxic dose: 32,760 mg/kg/26 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
JTPAE7 29,458,2001
oral
mouse
lowest published toxic dose: 32,760 mg/kg/26 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTPAE7 29,458,2001
oral
mouse
lowest published toxic dose: 131,040 mg/kg/26 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
JTPAE7 29,458,2001
oral
mouse
lowest published toxic dose: 131,040 mg/kg/26 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 29,458,2001
oral
mouse
lowest published toxic dose: 131,040 mg/kg/26 week- intermittent Liver: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JTPAE7 29,458,2001
oral
mouse
lowest published toxic dose: 24,000 mg/kg/10 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
BCPCA6 36,4221,1987
oral
mouse
lowest published toxic dose: 323 mg/kg/17 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #87119046
oral
mouse
lowest published toxic dose: 1,440 mg/kg/12 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB85-105674
oral
mouse
lowest published toxic dose: 2,040 mg/kg/17 day- continuous Liver: Changes in liver weight NTIS** #PB85-105674
oral
mouse
lowest published toxic dose: 4,250 mg/kg/17 day- continuous Behavioral: Sleep

Skin and Appendages: Other: Hair
NTIS** #PB85-105674
oral
mouse
lowest published toxic dose: 2.52 gm/kg/7 day- continuous Liver: Other changes

Liver: Changes in liver weight
EVHPAZ 110,363,2002
oral
mouse
lowest published toxic dose: 10.08 gm/kg/28 day- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
EVHPAZ 110,363,2002
oral
mouse
lowest published toxic dose: 7 gm/kg/1 week- intermittent Liver: Changes in liver weight TXCYAC 191,211,2003
oral
mouse
lowest published toxic dose: 15,120 mg/kg/3 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 204,109,2004
oral
mouse
lowest published toxic dose: 7,000 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 207,149,2005
oral
mouse
lowest published toxic dose: 109.2 gm/kg/13 week- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,353,2004
oral
mouse
lowest published toxic dose: 28,000 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Other changes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TOXID9 60,297,2001
oral
mouse
lowest published toxic dose: 24 mg/kg/48 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOXID9 60,297,2001
oral
mouse
lowest published toxic dose: 13,671.7 mg/kg/2 week- intermittent Liver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 81,219,2007
oral
pig
lowest published toxic dose: 3,600 mg/kg/4 week- intermittent Endocrine: Other changes REPTED 21,160,2006
oral
rat
lowest published toxic dose: 1,500 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Related to Chronic Data: Changes in testicular weight
VHTODE 37,310,1995
oral
rat
lowest published toxic dose: 139 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 8,219,1953
oral
rat
lowest published toxic dose: 17,500 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Related to Chronic Data: Changes in testicular weight
TXAPA9 61,205,1981
oral
rat
lowest published toxic dose: 59,388 mg/kg/6 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 15,389,1977
oral
rat
lowest published toxic dose: 168 gm/kg/17 week- continuous Blood: Other changes

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 15,389,1977
oral
rat
lowest published toxic dose: 19,796 mg/kg/12 week- continuous Liver: Changes in liver weight

Skin and Appendages: Other: Hair

Related to Chronic Data: Changes in testicular weight
FCTXAV 15,389,1977
oral
rat
lowest published toxic dose: 25,200 mg/kg/21 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TXAPA9 77,116,1985
oral
rat
lowest published toxic dose: 14 gm/kg/14 day- intermittent Liver: Other changes

Liver: Changes in liver weight
TOLED5 66,317,1993
oral
rat
lowest published toxic dose: 42 gm/kg/28 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0530399
oral
rat
lowest published toxic dose: 5,040 mg/kg/4 week- continuous Liver: Other changes

Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJCNAW 58,736,1994
oral
rat
lowest published toxic dose: 10,080 mg/kg/8 week- continuous Liver: Other changes

Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
IJCNAW 58,736,1994
oral
rat
lowest published toxic dose: 20,160 mg/kg/16 week- continuous Liver: Other changes

Endocrine: Estrogenic
IJCNAW 58,736,1994
oral
rat
lowest published toxic dose: 8,400 mg/kg/14 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 121,35,2001
oral
rat
lowest published toxic dose: 5.52 gm/kg/7 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 143.6 gm/kg/182 day- continuous Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 287.2 gm/kg/364 day- continuous Blood: Normocytic anemia

Biochemical: Metabolism (intermediary): Other
TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 170.8 gm/kg/182 day- continuous Blood: Normocytic anemia

Blood: Other changes

Biochemical: Metabolism (intermediary): Other
TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 26.7 gm/kg/182 day- continuous Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 4.2 gm/kg/104 week- continuous Kidney, Ureter, and Bladder: Other changes TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 21.04 gm/kg/104 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 106.7 gm/kg/104 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 132.3 gm/kg/104 week- continuous Liver: Changes in liver weight TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 683.2 gm/kg/104 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight TOSCF2 55,433,2000
oral
rat
lowest published toxic dose: 1,000 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 95,104,1988
oral
rat
lowest published toxic dose: 2,500 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 95,104,1988
oral
rat
lowest published toxic dose: 5,000 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 95,104,1988
oral
rat
lowest published toxic dose: 5,000 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
TXAPA9 95,104,1988
oral
rat
lowest published toxic dose: 10,000 mg/kg/5 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 95,104,1988
oral
rat
lowest published toxic dose: 5,000 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXAPA9 95,104,1988
oral
rat
lowest published toxic dose: 12,600 mg/kg/6 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain EVHPAZ 65,343,1986
oral
rat
lowest published toxic dose: 8,400 mg/kg/1 week- continuous Behavioral: Food intake (animal) EVHPAZ 65,343,1986
oral
rat
lowest published toxic dose: 72,000 mg/kg/60 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
EVHPAZ 65,343,1986
oral
rat
lowest published toxic dose: 18,000 mg/kg/60 day- continuous Liver: Changes in liver weight EVHPAZ 65,343,1986
oral
rat
lowest published toxic dose: 1,050 mg/kg/2 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) EVHPAZ 65,343,1986
oral
rat
lowest published toxic dose: 28,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
EVHPAZ 65,229,1986
oral
rat
lowest published toxic dose: 28,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in prostate weight
EVHPAZ 65,229,1986
oral
rat
lowest published toxic dose: 12,000 mg/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
ATSUDG 4,452,1980
oral
rat
lowest published toxic dose: 42,000 mg/kg/21 day- continuous Liver: Fatty liver degeneration EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 1,050 mg/kg/21 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Effect on specific coenzyme: CoA
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 21,000 mg/kg/21 day- continuous Liver: Other changes EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 1,050 mg/kg/21 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 4,200 mg/kg/21 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Effect on specific coenzyme: CoA
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 54,800 mg/kg/274 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 21,000 mg/kg/21 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 10,153 mg/kg/13 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 1,338 mg/kg/3 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 3,600 mg/kg/3 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Other changes
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 12,600 mg/kg/21 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Other changes
EVHPAZ 70,195,1986
oral
rat
lowest published toxic dose: 28 gm/kg/14 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
ENVRAL 36,160,1985
oral
rat
lowest published toxic dose: 36,000 mg/kg/12 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 128,216,1994
oral
rat
lowest published toxic dose: 16,000 mg/kg/8 day- intermittent Endocrine: Effect on menstrual cycle TXAPA9 128,216,1994
oral
rat
lowest published toxic dose: 6,000 mg/kg/3 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Reproductive: Maternal effects: Ovaries, fallopian tubes
TXAPA9 128,216,1994
oral
rat
lowest published toxic dose: 10,000 mg/kg/5 day- intermittent Endocrine: Other changes TXAPA9 128,216,1994
oral
rat
lowest published toxic dose: 28,000 mg/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 65,237,1986
oral
rat
lowest published toxic dose: 23,800 mg/kg/14 day- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
EVHPAZ 65,237,1986
oral
rat
lowest published toxic dose: 14,000 mg/kg/14 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 65,237,1986
oral
rat
lowest published toxic dose: 6,260 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #87119046
oral
rat
lowest published toxic dose: 11,460 mg/kg/20 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #87119046
oral
rat
lowest published toxic dose: 2,000 mg/kg/4 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB85-105658
oral
rat
lowest published toxic dose: 5,000 mg/kg/20 day- continuous Behavioral: Food intake (animal)

Liver: Changes in liver weight

Skin and Appendages: Other: Hair
NTIS** #PB85-105658
oral
rat
lowest published toxic dose: 8,400 mg/kg/1 week- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
PHTOEH 65,265,1989
oral
rat
lowest published toxic dose: 8,400 mg/kg/1 week- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 76,63,1995
oral
rat
lowest published toxic dose: 8.4 gm/kg/28 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Lipids including transport
LPDSAP 13,673,1978
oral
rat
lowest published toxic dose: 840 mg/kg/7 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ATSUDG 12,85,1988
oral
rat
lowest published toxic dose: 6,000 mg/kg/3 day- intermittent Endocrine: Change in gonadotropins

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
TXAPA9 128,216,1994
oral
rat
lowest published toxic dose: 2.52 gm/kg/7 day- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
EVHPAZ 110,363,2002
oral
rat
lowest published toxic dose: 2.1 gm/kg/7 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
EVHPAZ 110,363,2002
oral
rat
lowest published toxic dose: 10.08 gm/kg/28 day- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
EVHPAZ 110,363,2002
oral
rat
lowest published toxic dose: 8.4 gm/kg/28 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
EVHPAZ 110,363,2002
oral
rat
lowest published toxic dose: 140 mg/kg/14 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Other
BIREBV 65,1252,2001
oral
rat
lowest published toxic dose: 280 mg/kg/28 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Androgenic
BIREBV 65,1252,2001
oral
rat
lowest published toxic dose: 13,500 mg/kg/18 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain EVHPAZ 109,229,2001
oral
rat
lowest published toxic dose: 6 gm/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Other metals
TXCYAC 171,105,2002
oral
rat
lowest published toxic dose: 14 gm/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Other metals

Related to Chronic Data: Changes in testicular weight
TXCYAC 171,105,2002
oral
rat
lowest published toxic dose: 700 mg/kg/14 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 38,304 mg/kg /21 day- continuous Endocrine: Evidence of thyroid hyperfunction REPTED 16,709,2002
oral
rat
lowest published toxic dose: 38,304 mg/kg /21 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
REPTED 16,709,2002
oral
rat
lowest published toxic dose: 18,240 mg/kg /10 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
REPTED 16,709,2002
oral
rat
lowest published toxic dose: 134.4 gm/kg/28 day- continuous Liver: Other changes TOXID9 72,235,2003
oral
rat
lowest published toxic dose: 8,000 mg/kg/8 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
EVHPAZ 111,139,2003
oral
rat
lowest published toxic dose: 9,000 mg/kg/9 day- intermittent Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
EVHPAZ 111,139,2003
oral
rat
lowest published toxic dose: 6,836 mg/kg/2 week- intermittent Liver: Other changes TXAPA9 197,229,2004
oral
rat
lowest published toxic dose: 1,250 mg/kg/28 day- continuous Liver: Liver function tests impaired TXAPA9 197,231,2004
oral
rat
lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Liver: Changes in liver weight TXCYAC 208,115,2005
oral
rat
lowest published toxic dose: 2,000 mg/kg/10 day- intermittent Liver: Changes in liver weight

Related to Chronic Data: Changes in prostate weight
TXCYAC 208,115,2005
oral
rat
lowest published toxic dose: 500 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ARTODN 77,446,2003
oral
rat
lowest published toxic dose: 5,000 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in testicular weight
ARTODN 77,446,2003
oral
rat
lowest published toxic dose: 28,000 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TOXID9 1,72,2001
oral
rat
lowest published toxic dose: 12,600 mg/kg/5 week- intermittent Liver: Changes in liver weight REPTED 21,253,2006
oral
rat
lowest published toxic dose: 52,500 mg/kg/5 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 21,253,2006
oral
rat
lowest published toxic dose: 4 gm/kg/2 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
REPTED 22,77,2006
oral
rat
lowest published toxic dose: 4 gm/kg/2 day- intermittent Related to Chronic Data: Changes in testicular weight REPTED 22,77,2006
oral
rat
lowest published toxic dose: 14 gm/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 22,77,2006
oral
rat
lowest published toxic dose: 6,300 mg/kg/21 day- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
IJTOFN 22,159,2003
oral
rat
lowest published toxic dose: 11,400 mg/kg/19 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 22,159,2003
oral
rat
lowest published toxic dose: 3,000 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field IJTOFN 22,159,2003
oral
rat
lowest published toxic dose: 8,000 mg/kg/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 30,175,2005
oral
rat
lowest published toxic dose: 1.71 mg/kg/38 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight TOSCF2 91,247,2006
oral
rat
lowest published toxic dose: 15,390 mg/kg/38 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 91,247,2006
oral
rat
lowest published toxic dose: 13,671.7 mg/kg/2 week- intermittent Liver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 81,219,2007
oral
rat
lowest published toxic dose: 6,300 mg/kg/7 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TOLED5 173,107,2007
oral
rat
lowest published toxic dose: 9,350.32 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight REPTED 22,411,2006
oral
rat
lowest published toxic dose: 45,594.08 mg/kg/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 22,411,2006
oral
rat
lowest published toxic dose: 14,000 mg/kg/4 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TERP2* -,310,2004
oral
rat
lowest published toxic dose: 85,085 mg/kg/13 week- continuous Liver: Changes in liver weight MOCAE8 42,9,2005
oral
rabbit
lowest published toxic dose: 30 gm/kg/15 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 40,209,1988
oral
rabbit
lowest published toxic dose: 840 mg/kg/28 day- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
LPDSAP 13,673,1978
subcutaneous
mouse
lowest published toxic dose: 3 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Related to Chronic Data: Changes in testicular weight
JTEHD6 26,39,1989
skin
mouse
lowest published toxic dose: 30,000 mg/kg/15 day- intermittent Liver: Changes in liver weight TXCYAC 244,231,2008
unreported route
mouse
lowest published toxic dose: 2,300 mg/kg/2 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 60,205,2001
unreported route
mouse
: 3,450 mg/kg/3 day- intermittent Liver: Other changes

Liver: Changes in liver weight
TXCYAC 213,223,2005
unreported route
rat
lowest published toxic dose: 18,900 mg/kg/21 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in prostate weight
TOXID9 44,281,2005
unreported route
rat
lowest published toxic dose: 18,900 mg/kg/21 day- intermittent Related to Chronic Data: Changes in testicular weight TOXID9 44,281,2005
unreported route
rat
lowest published toxic dose: 18,900 mg/kg/21 day- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight
TOXID9 44,281,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 77,564,2000
TOXICOLOGY REVIEW
EVHPAZ 3,73,1973
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
ESKHA5 (93),1,1975
TOXICOLOGY REVIEW
TXAPA9 45,1,1978
TOXICOLOGY REVIEW
JTEHD6 9,141,1982
TOXICOLOGY REVIEW
JJATDK 8,75,1988
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
REPTED 16,679,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
TXAPA9 197,178,2004
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
ENTOX* -,733,2005
TOXICOLOGY REVIEW
CRTXB2 36,695,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
REPTED 22,291,2006
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
JTPAE7 20,197,2007
TOXICOLOGY REVIEW
HUTOX* -,649,1996
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,96,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 10 mg/m3, 2005
Occupational Exposure Limit - HUNGARY time-weighted average 10 mg/m3, short term exposure limit 40 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 mg/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DEHP-air Carcinogen;
10 hour time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0347;
Number of Industries 222;
Total Number of Facilities 33,723;
Number of Occupations 126;
Total Number of Employees Exposed 332,356
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0347;
Number of Industries 164;
Total Number of Facilities 19,879;
Number of Occupations 116;
Total Number of Employees Exposed 340,800;
Total Number of Female Employees Exposed 106,918


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182400/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as plasticizer for POLYVINYL CHLORIDE and dielectrical fluid component in capacitors
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9120
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Di(2-ethylhexyl) phthalate, 5020
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
OSHA ANALYTICAL METHOD #104


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Used as plasticizer for POLYVINYL CHLORIDE and dielectrical fluid component in capacitors

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

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