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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic anhydride, tetrachloro-

RTECS #

TI3450000

CAS #

117-08-8

Updated

April 2012

Molecular Weight

285.88

Molecular Formula

C8Cl4O3

Synonyms

1,3-Isobenzofurandione, 4,5,6,7-tetrachloro- (9CI)
4,5,6,7-Tetrachloro-1,3-isobenzofurandione
CP 626
NCI-C61585
Niagathal
Tetrachlorophthalic anhydride
Tetrathal

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg mildNTPTR* NIH-93-3351

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 28000 mg/kg (6-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HPV087 -,-,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >3600 mg/m3/4HHPV087 -,-,2002
oral/rat Lethal dose: >1000 mg/kgHPV087 -,-,2002
oral/rat lethal dose (50 percent kill): >15800 mg/kgNTPTR* NIH-93-3351
skin/rabbit lethal dose (50 percent kill): >5 gm/kgNTPTR* NIH-93-3351
skin/rabbit Lethal dose: >5010 mg/kgBehavioral: Somnolence (general depressed activity)HPV087 -,-,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 5 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Endocrine: Hyperglycemia

Blood: Changes in leukocyte (WBC) count
NTIS** OTS0538630
inhalation/rat lowest published toxic concentration: 0.73 mg/m3/13W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV087 -,-,2002
inhalation/rat lowest published toxic concentration: 36.3 mg/m3/13W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV087 -,-,2002
oral/mouse lowest published toxic dose: 24375 mg/kg/13W- intermittentBlood: Normocytic anemiaHPV087 -,-,2002
oral/mouse lowest published toxic dose: 97500 mg/kg/13W- intermittentBlood: Normocytic anemia

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
HPV087 -,-,2002
oral/rat lowest published toxic dose: 6110 mg/kg/13W- intermittentBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HPV087 -,-,2002
oral/rat lowest published toxic dose: 48750 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV087 -,-,2002
oral/rat lowest published toxic dose: 68250 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-93-3351

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, ceiling concentration 0.4 mg/m3, NOV2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M3316; Number of Industries 4; Total Number of Facilities 43; Number of Occupations 6; Total Number of Employees Exposed 2067; Total Number of Female Employees Exposed 786
National Occupational Hazard Survey 1974Hazard Code M3316; Number of Industries 2; Total Number of Facilities 55; Number of Occupations 3; Total Number of Employees Exposed 142

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8912
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-28, October 2000
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