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Phthalic acid, dimethyl ester

RTECS #: TI1575000

CAS #: 131-11-3


UPDATE: May 2009 MW: 194.20 MF: C10H10O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenedicarboxylic acid, dimethyl ester
  2. Avolin
  3. DMF (insect repellent)
  4. Dimethyl 1,2 - benzenedicarboxylate
  5. Dimethyl benzene - o - dicarboxylate
  6. Dimethyl benzeneorthodicarboxylate
  7. Dimethyl o - phthalate
  8. Dimethyl phthalate (ACGIH:OSHA)
  9. Dimethylester kyseliny ftalove (Czech)
  10. Dimethylphthalate
  11. ENT 262
  12. Fermine
  13. Methyl phthalate
  1. Mipax
  2. NTM
  3. Palatinol M
  4. Phthalate acid, dimethyl ester
  5. Phthalic acid methyl ester
  6. Phthalsaeuredimethylester (German)
  7. RCRA waste number U102
  8. Repeftal
  9. Solvanom
  10. Solvarone
  11. Unimoll DM
  12. o - Dimethyl phthalate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
119 mg N/R JPETAB 82,377,1944


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis skin
rat
25 gm/kg/4 week- intermittent FATOAO 40,454,1977
mutation in microorganisms Salmonella typhimurium 200 g/plate (+enzymatic activation step) JTEHD6 16,61,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 338 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 338 mg/kg (5-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Other developmental abnormalities
JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 1,125 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 1,500 mg/kg (3-9 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) JDSCAE 55,696,1972
intraperitoneal
rat
lowest published toxic dose: 3 mL/kg (3-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) EVHPAZ 3,91,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 9,300 mg/m3/6.5 hour N/R 14CYAT 2,1905,1963
inhalation
rat
lowest published toxic concentration: 10 mg/m3 Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 15,123,1979
intraperitoneal
mouse
lethal dose (50 percent kill): 1,380 mg/kg N/R IPSTB3 3,93,1976
intraperitoneal
rat
lethal dose (50 percent kill): 3,375 L/kg N/R JPMSAE 61,51,1972
intraperitoneal
rat
lethal dose (50 percent kill): 30.7 gm/kg N/R ENTOX* -,422,2005
oral
chicken
lethal dose (50 percent kill): 8,500 L/kg N/R JPETAB 93,26,1948
oral
dog
lethal dose : >1,400 mg/kg N/R EVHPAZ 3,61,1973
oral
guinea pig
lethal dose (50 percent kill): 2,400 L/kg N/R JPETAB 93,26,1948
oral
mouse
lethal dose (50 percent kill): 6,800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
oral
mouse
lethal dose (50 percent kill): >30 gm/kg N/R ENTOX* -,422,2005
oral
rat
lethal dose (50 percent kill): 6,800 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
oral
rat
lethal dose (50 percent kill): >25 gm/kg N/R ENTOX* -,422,2005
oral
rabbit
lethal dose (50 percent kill): 4,400 L/kg N/R JPETAB 93,26,1948
subcutaneous
mouse
lowest published lethal dose: 6,500 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
EDWU** -,-,1937
skin
guinea pig
lethal dose (50 percent kill): >10 mL/kg N/R JPETAB 93,26,1948
skin
rat
lethal dose (50 percent kill): >4,800 mg/kg N/R 85JFAN A154,1983
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R 38MKAJ 2A,2343,1981
unreported route
guinea pig
lethal dose (50 percent kill): 4,800 mg/kg N/R GTPZAB 32(7),52,1988
unreported route
mouse
lethal dose (50 percent kill): 6,800 mg/kg N/R GTPZAB 32(7),52,1988
unreported route
rat
lethal dose (50 percent kill): 9,500 mg/kg N/R GTPZAB 32(7),52,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,840 g/kg/4 hour/17 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
GISAAA 39(12),26,1974
intraperitoneal
rat
lowest published toxic dose: 3 mL/kg/7 day- intermittent Reproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 3,91,1973
oral
rat
lowest published toxic dose: 36 gm/kg/10 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB89164826/AS
oral
rat
lowest published toxic dose: 2 gm/kg/10 day- continuous Behavioral: Fluid intake NTIS** #PB89164826/AS
oral
rat
lowest published toxic dose: 8 gm/kg/10 day- continuous Behavioral: Food intake (animal) NTIS** #PB89164826/AS
skin
human
lowest published toxic dose: 1,290 mg/kg/30 day- intermittent Blood: Other changes TPKVAL 15,49,1979
skin
rabbit
lowest published toxic dose: 360 mL/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPETAB 93,26,1948


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EVHPAZ 3,73,1973
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
EVHPAZ 4,3,1973
TOXICOLOGY REVIEW
JACTDZ 4(3),267,1985
TOXICOLOGY REVIEW
EMCPT* 2,137,2005
TOXICOLOGY REVIEW
ENTOX* -,422,2005
TOXICOLOGY REVIEW
IJTOFN 24,1,2005
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,91,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.3 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLPHTHALATE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 59210;
Number of Industries 38;
Total Number of Facilities 2,879;
Number of Occupations 58;
Total Number of Employees Exposed 50,231
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 59210;
Number of Industries 56;
Total Number of Facilities 6,174;
Number of Occupations 66;
Total Number of Employees Exposed 57,908;
Total Number of Female Employees Exposed 16,352


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as plasticizer and dye carrier
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #104


REFERENCES:

CODEN
REFERENCE

14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EDWU** "Beitrag zur Toxikologie Technischer Weichmachungsmittel, Dissertation," Eller, H., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937
EMCPT* EMC-Toxicologie Pathologie (Elsevier) V.1- 2004-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JDSCAE Journal of Dairy Science. (American Dairy Science Assoc., 309 W. Clark St., Champaign, IL 61820) V.1- 1917-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as plasticizer and dye carrier

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 64441-70-9
Click Here for Additional Information about RTECS

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