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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic acid, diisodecyl ester

RTECS #

TI1270000

CAS #

26761-40-0

Updated

April 2012

Molecular Weight

446.74

Molecular Formula

C28H46O4

Synonyms

1,2-Benzenedicarboxylic acid, diisodecyl ester (9CI)
Bis(isodecyl)phthalate
DIDP (plasticizer)
Diisodecyl phthalate
Palatinol Z
Sicol 184
Vestinol DZ

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTOD7 35,501,1997

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 12645.36 mg/kg/104W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Tumorigenic: Increased incidence of tumors in susceptible strains
TOLED5 178,110,2008
oral/rat lowest published toxic dose: 9726.08 mg/kg/104W- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Tumorigenic: Increased incidence of tumors in susceptible strains
TOLED5 178,110,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lethal concentration: >130 mg/m3/6HEXXON*
inhalation/mouse Lethal concentration: >130 mg/m3/6HEXXON*
inhalation/rat Lethal concentration: >130 mg/m3/6HEXXON*
oral/rabbit lowest published lethal dose: 22500 µL/kgEVHPAZ 3,61,1973
oral/rat lethal dose (50 percent kill): 64 gm/kgEVHPAZ 3,131,1973
skin/rabbit lethal dose (50 percent kill): >3160 mg/kgEXXON*

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 58800 mg/kg/14W- continuousLiver: Changes in liver weightEVHPAZ 3,131,1973
oral/rat lowest published toxic dose: 1680 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight
NTIS** OTS0530400
oral/rat lowest published toxic dose: 14000 mg/kg/4W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)TERP2* -,310,2004
oral/rat lowest published toxic dose: 9726.08 mg/kg/104W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 178,110,2008
oral/rat lowest published toxic dose: 618.8 mg/kg/104W- continuousLiver: Other changes

Endocrine: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOLED5 178,110,2008
oral/rat lowest published toxic dose: 385.84 mg/kg/104W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes
TOLED5 178,110,2008
oral/rat lowest published toxic dose: 40320 mg/kg/12W- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOLED5 178,110,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTXAPA9 197,178,2004
TOXICOLOGY REVIEWCRTXB2 36,695,2006
TOXICOLOGY REVIEWREPTED 22,291,2006
TOXICOLOGY REVIEWMUREAV 728,118,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 3 mg/m3;KZW 5 mg/m3, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83278; Number of Industries 53; Total Number of Facilities 2962; Number of Occupations 57; Total Number of Employees Exposed 80441; Total Number of Female Employees Exposed 31734
National Occupational Hazard Survey 1974Hazard Code 83278; Number of Industries 18; Total Number of Facilities 1017; Number of Occupations 41; Total Number of Employees Exposed 21856

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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