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Phthalic acid, diisobutyl ester

RTECS #: TI1225000

CAS #: 84-69-5


UPDATE: May 2008 MW: 278.38 MF: C16H22O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. DIBP
  2. Diisobutylester kyseliny ftalove (Czech)
  3. Diisobutyl phthalate
  4. Hatcol DIBP
  1. Hexaplas M/1B
  2. Kodaflex DIBP
  3. Palatinol IC


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human lymphocyte 354 mmol/L MUREAV 467,21,2000
DNA damage human other cell types 354 mmol/L MUREAV 467,21,2000
DNA damage human other cell types 216 Ámol/L/60 minute EMMUEG 35,9,2000
DNA damage human lymphocyte 354 mmol/L/60 minute TCMUD8 21,189,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1,250 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 375 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 61,51,1972
oral
mouse
lowest published toxic dose: 16,800 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOLED5 5,413,1980
oral
mouse
lowest published toxic dose: 32 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
rat
lowest published toxic dose: 8,400 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 53,35,1980
oral
rat
lowest published toxic dose: 11,250 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Urogenital system
TXCYAC 213,231,2005
oral
rat
lowest published toxic dose: 7,500 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXCYAC 213,231,2005
oral
rat
lowest published toxic dose: 7,800 mg/kg (7-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOLED5 163,183,2006
oral
rat
lowest published toxic dose: 11,250 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 165,39,2006
oral
rat
lowest published toxic dose: 7,500 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOLED5 165,39,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 3,990 mg/kg N/R JSCCA5 28,667,1977
intraperitoneal
rat
lethal dose (50 percent kill): 3,750 ÁL/kg N/R JPMSAE 61,51,1972
oral
mouse
lethal dose (50 percent kill): 10 gm/kg Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 29(12),39,1985
oral
rat
lethal dose (50 percent kill): 15 gm/kg N/R EVHPAZ 3,131,1973
skin
guinea pig
lethal dose (50 percent kill): 10 gm/kg N/R EVHPAZ 4,3,1973
unreported route
mouse
lethal dose (50 percent kill): 10,500 mg/kg N/R GTPZAB 32(7),52,1988
unreported route
rat
lethal dose (50 percent kill): 20,500 mg/kg N/R GTPZAB 32(7),52,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
: 7,500 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 213,231,2005
oral
rat
lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 165,39,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
EVHPAZ 3,73,1973
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
EVHPAZ 4,3,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82792;
Number of Industries 5;
Total Number of Facilities 118;
Number of Occupations 9;
Total Number of Employees Exposed 3,373
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82792;
Number of Industries 7;
Total Number of Facilities 230;
Number of Occupations 19;
Total Number of Employees Exposed 9,522;
Total Number of Female Employees Exposed 380


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as plasticizer

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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