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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic acid, diisobutyl ester

RTECS #

TI1225000

CAS #

84-69-5

Updated

April 2012

Molecular Weight

278.38

Molecular Formula

C16H22O4

Synonyms

DIBP
Diisobutyl phthalate
Diisobutylester kyseliny ftalove (Czech)
Hatcol DIBP
Hexaplas M/1B
Kodaflex DIBP
Palatinol IC

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human354 mmol/LMUREAV 467,21,2000
DNA Damageother cell types/human354 mmol/LMUREAV 467,21,2000
DNA Damageother cell types/human216 µmol/L/60MEMMUEG 35,9,2000
DNA Damagelymphocyte/human354 mmol/L/60MTCMUD8 21,189,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 1250 mg/kg (5-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JPMSAE 61,51,1972
intraperitoneal/rat 375 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 61,51,1972
oral/mouse 16800 mg/kg (7D male)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOLED5 5,413,1980
oral/mouse 32 gm/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TCMUD8 7,29,1987
oral/rat 11250 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Urogenital system
TXCYAC 213,231,2005
oral/rat 7500 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TXCYAC 213,231,2005
oral/rat 7800 mg/kg (7-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOLED5 163,183,2006
oral/rat 11250 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 165,39,2006
oral/rat 7500 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system
TOLED5 165,39,2006
oral/rat 1250 mg/kg (12-21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)REPTED 26,107,2008
oral/rat 5000 mg/kg (12-21D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 26,107,2008
oral/rat 8400 mg/kg (7D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductTXAPA9 53,35,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 3990 mg/kgJSCCA5 28,667,1977
intraperitoneal/rat lethal dose (50 percent kill): 3750 µL/kgJPMSAE 61,51,1972
oral/mouse lethal dose (50 percent kill): 10 gm/kgBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
GTPZAB 29(12),39,1985
oral/rat lethal dose (50 percent kill): 15 gm/kgEVHPAZ 3,131,1973
skin/guinea pig lethal dose (50 percent kill): 10 gm/kgEVHPAZ 4,3,1973
unreported route/mouse lethal dose (50 percent kill): 10500 mg/kgGTPZAB 32(7),52,1988
unreported route/rat lethal dose (50 percent kill): 20500 mg/kgGTPZAB 32(7),52,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat : 7500 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 213,231,2005
oral/rat lowest published toxic dose: 2000 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOLED5 165,39,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 3,73,1973
TOXICOLOGY REVIEWRREVAH 54,1,1975
TOXICOLOGY REVIEWEVHPAZ 4,3,1973
TOXICOLOGY REVIEWRTOPDW 53,90,2009
TOXICOLOGY REVIEWMUTAEX 26,231,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82792; Number of Industries 7; Total Number of Facilities 230; Number of Occupations 19; Total Number of Employees Exposed 9522; Total Number of Female Employees Exposed 380
National Occupational Hazard Survey 1974Hazard Code 82792; Number of Industries 5; Total Number of Facilities 118; Number of Occupations 9; Total Number of Employees Exposed 3373

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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