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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic acid, diheptyl ester

RTECS #

TI1090000

CAS #

3648-21-3

Updated

July 2012

Molecular Weight

362.56

Molecular Formula

C22H34O4

Synonyms

1,2-Benzenedicarboxylic acid, diheptyl ester (9CI)
Diheptyl phthalate
Di-n-heptyl phthalate
Heptyl phthalate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageoral/rat70 gm/kg/14D- intermittentTXCYAC 264,16,2009

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 2500 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendagesSEIJBO 17,380,1977

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 140 mg/kg/28DTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 264,16,2009

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 28 gm/kg/28D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ESKHA5 (110),26,1992

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3, 2007

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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