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Phthalic acid, benzyl butyl ester

RTECS #: TH9990000

CAS #: 85-68-7


UPDATE: May 2009 MW: 312.39 MF: C19H20O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenedicarboxylic acid, butyl phenylmethyl ester
  2. AI3 - 14777
  3. BBP
  4. Benzyl butyl phthalate
  5. Benzyl n - butyl phthalate
  6. Benzyl - butylester kyseliny ftalove (Czech)
  7. Butyl benzyl phthalate
  1. Butyl phenylmethyl 1,2 - benzenedicarboxylate
  2. NCI - C54375
  3. Palatinol BB
  4. Santicizer 160
  5. Sicol 160
  6. Unimoll BB
  7. n - Butyl benzyl phthalate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 2,000 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
morphological transform hamster embryo 2 mg/L MUREAV 356,85,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 9,100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus
NTIS** PB91-129999
oral
mouse
lowest published toxic dose: 23,300 mg/kg (6-15 day pregnant) Reproductive: Other effects on female NTIS** PB91-129999
oral
mouse
lowest published toxic dose: 9.1 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NTIS** #PB91-129999
oral
mouse
lowest published toxic dose: 23.3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB91-129999
oral
mouse
lowest published toxic dose: 562 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 17,575,2003
oral
mouse
lowest published toxic dose: 1.12 gm/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death REPTED 17,575,2003
oral
mouse
lowest published toxic dose: 1,686 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) REPTED 17,575,2003
oral
rat
lowest published toxic dose: 21 gm/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOXID9 4,136,1984
oral
rat
lowest published toxic dose: 16,400 mg/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB90-115346
oral
rat
lowest published toxic dose: 16,400 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB90-115346
oral
rat
lowest published toxic dose: 4,900 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 12,57,1992
oral
rat
lowest published toxic dose: 154 gm/kg (10 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
NTPTR* NTP-TR-458,1997
oral
rat
lowest published toxic dose: 4,500 mg/kg (0-8 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 12,127,1998
oral
rat
lowest published toxic dose: 1,500 mg/kg (6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JJATDK 19,357,1999
oral
rat
lowest published toxic dose: 11,600 mg/kg (2 week prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 369.8 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
RTOPDW 26,330,1997
oral
rat
lowest published toxic dose: 119 gm/kg (14 week male/14 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 24 gm/kg (14 week male/14 week prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 24 gm/kg (14 week male/14 week prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Behavioral
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 5 gm/kg (14 week male/14 week prior to copulation-21 day after birth) Reproductive: Effects on newborn: Physical REPTED 14,513,2000
oral
rat
lowest published toxic dose: 2,700 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 14,417,2000
oral
rat
lowest published toxic dose: 5,800 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) REPTED 14,417,2000
oral
rat
lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear REPTED 14,417,2000
oral
rat
lowest published toxic dose: 11,250 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
REPTED 14,417,2000
oral
rat
lowest published toxic dose: 5,700 g/kg (2 week prior to copulation-22 week after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 11.3 mg/kg (10 week prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
oral
rat
lowest published toxic dose: 1,100 mg/kg (1-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 8,231,1994
oral
rat
lowest published toxic dose: 12.8 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 43 gm/kg (1-29 day male/14 day prior to copulation-6 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 85 gm/kg (1-29 day male/14 day prior to copulation-6 day after birth) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 20,000 mg/kg (1-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 8,000 mg/kg (6-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 11 gm/kg (6-15 day pregnant) Reproductive: Other developmental abnormalities NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 16.4 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 3,000 mg/kg (15-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 16,71,2002
oral
rat
lowest published toxic dose: 1,500 mg/kg (15-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 16,71,2002
oral
rat
lowest published toxic dose: 5,000 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),272,2003
oral
rat
lowest published toxic dose: 1,687 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 17,575,2003
oral
rat
lowest published toxic dose: 42.8 gm/kg (7 day male/7 day prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 18,1,2004
oral
rat
lowest published toxic dose: 750 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
REPTED 18,1,2004
oral
rat
lowest published toxic dose: 750 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 18,1,2004
oral
rat
lowest published toxic dose: 9,000 mg/kg (7 day male/7 day prior to copulation/22 day pregnant) Reproductive: Other developmental abnormalities REPTED 18,1,2004
oral
rat
lowest published toxic dose: 9,000 mg/kg (14-22 day pregnant/3 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 18,1,2004
oral
rat
lowest published toxic dose: 7,500 mg/kg (1-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOXID9 44,227,2005
oral
rat
lowest published toxic dose: 3,750 mg/kg (14-18 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 78,282,2004
unreported route
rat
lowest published toxic dose: 41,250 mg/kg (14 day pregnant-3 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,225,2001
unreported route
rat
lowest published toxic dose: 2,500 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 60,225,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 433 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
NTPTR* NTP-TR-213,1982
oral
rat
toxic dose : 437 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
EVHPAZ 65,271,1986
oral
rat
lowest published toxic dose: 364 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-458,1997
oral
rat
lowest published toxic dose: 117,600 mg/kg/28 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NTIS** PB83-118398
oral
rat
lowest published toxic dose: 360,500 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB98-131089
oral
rat
lowest published toxic dose: 865,200 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTIS** PB98-131089
oral
rat
lowest published toxic dose: 524,160 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB98-131014


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 3,160 mg/kg N/R EVHPAZ 4,3,1973
oral
guinea pig
lethal dose (50 percent kill): 13,750 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
oral
mouse
lethal dose (50 percent kill): 4,170 mg/kg N/R IMEMDT 29,193,1982
oral
mouse
lethal dose : 2.3 gm/kg N/R REPTED 17,575,2003
oral
mouse
lowest published toxic dose: 1,124 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,575,2003
oral
rat
lethal dose (50 percent kill): 2,330 mg/kg N/R IMEMDT 29,193,1982
skin
mouse
lethal dose (50 percent kill): 6,700 mg/kg N/R GISAAA 39(6),25,1974
skin
rat
lethal dose (50 percent kill): 6,700 mg/kg N/R GISAAA 39(6),25,1974
skin
rabbit
lethal dose (50 percent kill): >10 gm/kg N/R TIHEEC 3,79,1987
unreported route
mouse
lethal dose (50 percent kill): 13,700 g/kg N/R GTPZAB 32(7),52,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,100 mg/m3/6 hour/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 3,79,1987
inhalation
rat
lowest published toxic concentration: 789 mg/m3/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 3,79,1987
oral
mouse
lowest published toxic dose: 273 gm/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-213,1982
oral
mouse
lowest published toxic dose: 9.1 gm/kg/10 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB91-129999
oral
mouse
lowest published toxic dose: 23.3 gm/kg/10 day- continuous Behavioral: Food intake (animal)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB91-129999
oral
mouse
lowest published toxic dose: 23.3 gm/kg/10 day- continuous Behavioral: Fluid intake NTIS** #PB91-129999
oral
rat
lowest published toxic dose: 56 gm/kg/4 week- continuous Behavioral: Food intake (animal)

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 3,79,1987
oral
rat
lowest published toxic dose: 68,250 mg/kg/91 day- continuous Liver: Changes in liver weight JACTDZ 11,1,1992
oral
rat
lowest published toxic dose: 38,402 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TIHEEC 3,79,1987
oral
rat
lowest published toxic dose: 21 gm/kg/14 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
TXCYAC 35,189,1985
oral
rat
lowest published toxic dose: 51,450 mg/kg/21 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0536510
oral
rat
lowest published toxic dose: 14,100 mg/kg/141 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Changes in kidney weight
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 70,500 mg/kg/141 day- intermittent Endocrine: Evidence of thyroid hypofunction

Related to Chronic Data: Changes in ovarian weight
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 9,800 mg/kg/14 week- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Endocrine: Other changes
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 49,000 mg/kg/14 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 10,500 mg/kg/21 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thyroid weight
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 32,000 mg/kg/64 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thyroid weight
REPTED 14,513,2000
oral
rat
lowest published toxic dose: 16,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
REPTED 14,417,2000
oral
rat
lowest published toxic dose: 7,500 mg/kg/10 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
REPTED 14,417,2000
oral
rat
lowest published toxic dose: 2,700 mg/kg/10 day- intermittent Blood: Changes in spleen REPTED 14,417,2000
oral
rat
lowest published toxic dose: 8,700 mg/kg/15 day- intermittent Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
REPTED 14,417,2000
oral
rat
lowest published toxic dose: 18,750 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 14,417,2000
oral
rat
lowest published toxic dose: 5,250 mg/kg/15 day- intermittent Liver: Changes in liver weight REPTED 14,417,2000
oral
rat
lowest published toxic dose: 4,050 mg/kg/15 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases REPTED 14,417,2000
oral
rat
lowest published toxic dose: 6,750 mg/kg/15 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight REPTED 14,417,2000
oral
rat
lowest published toxic dose: 117,600 mg/kg/28 week- continuous Liver: Changes in liver weight

Blood: Changes in spleen
NTIS** PB83-118398
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
REPTED 8,231,1994
oral
rat
lowest published toxic dose: 8,000 mg/kg/8 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 13,000 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 29,000 mg/kg/29 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 7,000 mg/kg/7 day- intermittent Behavioral: Food intake (animal) TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 7,000 mg/kg/14 day- intermittent Behavioral: Food intake (animal) TXCYAC 99,191,1995
oral
rat
lowest published toxic dose: 4.2 gm/kg/10 day- continuous Behavioral: Fluid intake NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 11 gm/kg/10 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 7.7 gm/kg/7 day- continuous Behavioral: Food intake (animal) NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 4.4 gm/kg/4 day- continuous Behavioral: Fluid intake NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 16.4 gm/kg/10 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB90-115346/AS
oral
rat
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 16,71,2002
oral
rat
lowest published toxic dose: 700 mg/kg/14 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Liver: Other changes
FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 14 gm/kg/14 day- intermittent Liver: Changes in liver weight FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 42,750 mg/kg/57 day- intermittent Liver: Changes in liver weight REPTED 18,1,2004
oral
rat
lowest published toxic dose: 14,000 mg/kg/4 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TERP2* -,310,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 73,115,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 29,193,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 29,193,1982
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,115,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,115,1999
TOXICOLOGY REVIEW
JACTDZ 11,1,1992
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TXAPA9 197,178,2004
TOXICOLOGY REVIEW
CRTXB2 36,695,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
REPTED 22,291,2006
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80249;
Number of Industries 93;
Total Number of Facilities 9,594;
Number of Occupations 74;
Total Number of Employees Exposed 66,289
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80249;
Number of Industries 158;
Total Number of Facilities 27,154;
Number of Occupations 119;
Total Number of Employees Exposed 331,841;
Total Number of Female Employees Exposed 59,743


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9016;8EHQ-0892-9174
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8845
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* NTP-TR-458,1997
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TERP2*
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as plasticizer

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 58128-78-2
Click Here for Additional Information about RTECS

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