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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorous acid, triphenyl ester

RTECS #

TH1575000

CAS #

101-02-0

Updated

April 2012

Molecular Weight

310.30

Molecular Formula

C18H15O3P

Synonyms

ADK Stab TPP
Advance TPP
JP 360
Mellite 310
Phenyl phosphite ((C6H5O)3P) (6CI,7CI)
Phosclere T 36
Sumilizer TPP-R
Sumilizer TTP-R
TP 1 (plasticizer)
TPP (plasticizer)
Trifenoxyfosfin (Czech)
Trifenylfosfit (Czech)
Triphenoxyphosphine
Triphenyl phosphite
Tris(phenoxy)phosphine
Weston TPP

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,1117,1986
skin /human 125 mg/48H severeAMIHBC 5,311,1952
skin /rabbit 500 mg severeAMIHBC 5,311,1952
skin /rabbit 20 mg/24H moderate85JCAE -,1117,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >6700 mg/m3/1HNTIS** OTS0532280
inhalation/rat lethal concentration (50 percent kill): >6700 mg/m3/1HHPV269 -,-,2001
intraperitoneal/cat lowest published lethal dose: 100 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
NTIS** OTS0570901
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 250 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
AMIHBC 5,311,1952
intraperitoneal/mouse lethal dose (50 percent kill): 266 mg/kgABCHA6 31,1288,1967
intraperitoneal/rat lethal dose (50 percent kill): 250 mg/kg85JCAE -,1117,1986
intravenous/chicken lowest published lethal dose: 50 mg/kgAutonomic Nervous System: Ganglion blockerNEZAAQ 44,118,1989
oral/chicken lowest published lethal dose: 250 mg/kgBehavioral: AtaxiaNTIS** OTS0532280
oral/mouse lethal dose (50 percent kill): 1080 mg/kgGTPZAB 31(12),53,1987
oral/rat lethal dose (50 percent kill): 444 mg/kgGISAAA 46(12),13,1981
oral/rat lethal dose (50 percent kill): 1.59 gm/kgBehavioral: ComaHPV269 -,-,2001
skin/rabbit lethal dose (50 percent kill): >2 gm/kgSkin: After topical application: Primary irritationHPV269 -,-,2001
skin/rabbit lowest published lethal dose: 5 gm/kgBehavioral: Coma

Skin: After topical application: Primary irritation
HPV269 -,-,2001
skin/rabbit lowest published lethal dose: 5 gm/kgBehavioral: Somnolence (general depressed activity)NTIS** OTS0532280
subcutaneous/cat lowest published lethal dose: 300 mg/kgBehavioral: AtaxiaJPETAB 49,78,1933
subcutaneous/chicken lowest published lethal dose: 375 mg/kgBehavioral: Food intake (animal)

Behavioral: Ataxia
NTIS** OTS0532280
subcutaneous/chicken lowest published toxic dose: 500 mg/kgBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
TOXID9 66,315,2002
subcutaneous/chicken lowest published toxic dose: 500 mg/kgBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)
IJTOFN 23,259,2004
subcutaneous/mammal (species unspecified) lowest published toxic dose: 1184 mg/kgSpinal Cord: Other degenerative changes

Eye: Optic nerve neuropathy

Eye: Other eye effects
NRTXDN 23,33,2002
subcutaneous/mammal (species unspecified) lowest published toxic dose: 1184 mg/kgBrain and Coverings: Other degenerative changes

Eye: Optic nerve neuropathy

Eye: Retinal changes pigmentary deposition, retinitis, other)
NRTXDN 23,33,2002
subcutaneous/rat lowest published lethal dose: 2 gm/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Muscle weakness
JPETAB 49,78,1933
unreported route/mouse lethal dose (50 percent kill): 1360 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Change in motor activity (specific assay)
GTPZAB 21(9),55,1977
unreported route/rat lethal dose (50 percent kill): 1490 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Change in motor activity (specific assay)
GTPZAB 21(9),55,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 9 mg/m3/4H/45D- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 21(9),55,1977
parenteral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)
TOXID9 60,374,2001
parenteral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentBehavioral: Ataxia

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 60,374,2001
skin/chicken lowest published toxic dose: 5 gm/kg/5D- intermittentBehavioral: Ataxia

Skin: After systemic exposure: Dermatitis, other

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NTIS** OTS0532280
subcutaneous/rat lowest published toxic dose: 3552 mg/kg/7D- intermittentBrain and Coverings: Recordings from specific areas of CNS

Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Ataxia
FAATDF 29,110,1996

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 726,91,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82978; Number of Industries 45; Total Number of Facilities 6115; Number of Occupations 46; Total Number of Employees Exposed 84276; Total Number of Female Employees Exposed 6323
National Occupational Hazard Survey 1974Hazard Code 82978; Number of Industries 15; Total Number of Facilities 394; Number of Occupations 34; Total Number of Employees Exposed 10448

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0393-8740
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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